scholarly journals Combined Action of Nucleic Acid-Sensing Toll-like Receptors and TLR11/TLR12 Heterodimers Imparts Resistance to Toxoplasma gondii in Mice

2013 ◽  
Vol 13 (1) ◽  
pp. 42-53 ◽  
Author(s):  
Warrison A. Andrade ◽  
Maria do Carmo Souza ◽  
Espiridion Ramos-Martinez ◽  
Kamalpreet Nagpal ◽  
Miriam S. Dutra ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Toxoplasma Gondii ◽  
Toll Like Receptors ◽  
Combined Action

scholarly journals Bat Red Blood Cells express Nucleic Acid Sensing Receptors and bind RNA and DNA

2022 ◽  
Author(s):  
LK Metthew Lam ◽  
Jane Dobkin ◽  
Kaitlyn A. Eckart ◽  
Ian Gereg ◽  
Andrew DiSalvo ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Red Blood Cells ◽  
Immune Function ◽  
Blood Cells ◽  
Toll Like Receptors ◽  
Cpg Dna ◽  
Human Rbcs ◽  
Insight Into ◽  
Rna And Dna

Red blood cells (RBCs) demonstrate immunomodulatory capabilities through the expression of nucleic acid sensors. Little is known about bat RBCs, and no studies have examined the immune function of bat erythrocytes. Here we show that bat RBCs express the nucleic acid-sensing Toll-like receptors TLR7 and TLR9 and bind the nucleic acid ligands, single-stranded RNA, and CpG DNA. Collectively, these data suggest that, like human RBCs, bat erythrocytes possess immune function and may be reservoirs for nucleic acids. These findings provide unique insight into bat immunity and may uncover potential mechanisms by which virulent pathogens in humans are concealed in bats.

scholarly journals The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii

2021 ◽  
Vol 11 ◽  
Author(s):  
Luiz Carlos De Mattos ◽  
Ana Iara Costa Ferreira ◽  
Karina Younan de Oliveira ◽  
Fabiana Nakashima ◽  
Cinara Cássia Brandão
Keyword(s):  
Toxoplasma Gondii ◽  
Blood Group ◽  
Association Studies ◽  
Exocrine Secretion ◽  
Potential Contribution ◽  
Blood Group System ◽  
Pathogenic Microorganisms ◽  
Cell Tissue ◽  
Biological Relationship ◽  
Combined Action

The glycosyltransferases encoded by genes from the human ABO, Lewis, and Secretor histo-blood group systems synthesize part of the carbohydrate antigens in hematopoietic and non-hematopoietic tissues. The combined action of these glycosyltransferases strongly influences cell, tissue, mucosa, and exocrine secretion carbohydrate phenotypes, including those serving as habitat for mutualistic and pathogenic microorganisms. A set of reports investigated associations between Toxoplasma gondii infection and the ABO histo-blood group system, but the results are contradictory. As T. gondii uses the gastrointestinal tract as a route for infection, and in this organ, the expression of ABO, Lewis, and Secretor histo-blood group carbohydrates occurs, it is reasonable to suppose some biological relationship between them. This text reviewed association studies published in recent decades focusing on the potential contribution of the ABO, Lewis, and Secretor histo-blood group carbohydrates and infection by T. gondii.

scholarly journals Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo

2019 ◽  
Vol 10 ◽  
Author(s):  
Anna Hafner ◽  
Ulrike Kolbe ◽  
Isabel Freund ◽  
Virginia Castiglia ◽  
Pavel Kovarik ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Streptococcus Pyogenes ◽  
Crucial Role ◽  
Toll Like Receptors

scholarly journals UNC93B1 and Nucleic Acid-sensing Toll-like Receptors Mediate Host Resistance to Infection withLeishmania major

2013 ◽  
Vol 288 (10) ◽  
pp. 7127-7136 ◽  
Author(s):  
Bruno Luiz Fonseca Schamber-Reis ◽  
Patricia M. Petritus ◽  
Braulia C. Caetano ◽  
Espiridion R. Martinez ◽  
Kendi Okuda ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Host Resistance ◽  
Toll Like Receptors ◽  
Resistance To Infection

The ex vivo infection of human placental chorionic villi explants with Trypanosoma cruzi and Toxoplasma gondii is mediated by different toll-like receptors

Placenta ◽  
2016 ◽  
Vol 45 ◽  
pp. 86 ◽  
Author(s):  
Lorena Muñoz ◽  
Christian Castillo ◽  
Ileana Carrillo ◽  
Andrea Salinas ◽  
Ana Liempi ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Trypanosoma Cruzi ◽  
Ex Vivo ◽  
Toll Like Receptors ◽  
Chorionic Villi

Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys – a preliminary pilot study

Lupus ◽  
2008 ◽  
Vol 17 (6) ◽  
pp. 580-585 ◽  
Author(s):  
H Ciferska ◽  
P Horak ◽  
YT Konttinen ◽  
K Krejci ◽  
T Tichy ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Pilot Study ◽  
Nucleic Acid Binding ◽  
Toll Like Receptors ◽  
Transplanted Kidneys

Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9

Immunobiology ◽  
2008 ◽  
Vol 213 (3-4) ◽  
pp. 315-328 ◽  
Author(s):  
Stefan Bauer ◽  
Stephanie Pigisch ◽  
Doris Hangel ◽  
Andreas Kaufmann ◽  
Svetlana Hamm
Keyword(s):  
Nucleic Acid ◽  
Toll Like Receptors ◽  
Nucleic Acid Analogs

scholarly journals Toward a structural understanding of nucleic acid-sensing Toll-like receptors in the innate immune system

FEBS Letters ◽  
2017 ◽  
Vol 591 (20) ◽  
pp. 3167-3181 ◽  
Author(s):  
Zhikuan Zhang ◽  
Umeharu Ohto ◽  
Toshiyuki Shimizu
Keyword(s):  
Immune System ◽  
Nucleic Acid ◽  
Innate Immune System ◽  
Innate Immune ◽  
Toll Like Receptors
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