The effect of supplemental imaging on interval cancer rates in mammography screening: Systematic Review

Abstract Objectives To investigate whether artificial intelligence (AI) can reduce interval cancer in mammography screening. Materials and methods Preceding screening mammograms of 429 consecutive women diagnosed with interval cancer in Southern Sweden between 2013 and 2017 were analysed with a deep learning–based AI system. The system assigns a risk score from 1 to 10. Two experienced breast radiologists reviewed and classified the cases in consensus as true negative, minimal signs or false negative and assessed whether the AI system correctly localised the cancer. The potential reduction of interval cancer was calculated at different risk score thresholds corresponding to approximately 10%, 4% and 1% recall rates. Results A statistically significant correlation between interval cancer classification groups and AI risk score was observed (p < .0001). AI scored one in three (143/429) interval cancer with risk score 10, of which 67% (96/143) were either classified as minimal signs or false negative. Of these, 58% (83/143) were correctly located by AI, and could therefore potentially be detected at screening with the aid of AI, resulting in a 19.3% (95% CI 15.9–23.4) reduction of interval cancer. At 4% and 1% recall thresholds, the reduction of interval cancer was 11.2% (95% CI 8.5–14.5) and 4.7% (95% CI 3.0–7.1). The corresponding reduction of interval cancer with grave outcome (women who died or with stage IV disease) at risk score 10 was 23% (8/35; 95% CI 12–39). Conclusion The use of AI in screen reading has the potential to reduce the rate of interval cancer without supplementary screening modalities. Key Points • Retrospective study showed that AI detected 19% of interval cancer at the preceding screening exam that in addition showed at least minimal signs of malignancy. Importantly, these were correctly localised by AI, thus obviating supplementary screening modalities. • AI could potentially reduce a proportion of particularly aggressive interval cancers. • There was a correlation between AI risk score and interval cancer classified as true negative, minimal signs or false negative.

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Interval Breast Cancers in the NHS Breast Screening Programme: Does the Current Definition Exclude Too Many?

Journal of Medical Screening ◽

10.1177/096914139700400310 ◽

1997 ◽

Vol 4 (3) ◽

pp. 169-173 ◽

Cited By ~ 11

Author(s):

A M Faux ◽

D C Richardson ◽

G M Lawrence ◽

M E Wheaton ◽

M G Wallisconsultant

Keyword(s):

Breast Screening ◽

Interval Cancer ◽

Breast Cancers ◽

Interval Cancers ◽

Exclusion Criteria ◽

National Statistics ◽

Screening Unit ◽

Cancer Rates ◽

Definition Of ◽

The Impact

Objectives— To examine the impact of the definition of interval breast cancers on interval cancer rates arising from the prevalent (first) screening round. Design— Interval breast cancers arising from the prevalent (first) screening round at the Warwickshire, Solihull and Coventry Breast Screening Unit (17 April 1989 to 31 March 1992) were identified by comparison of data held at the unit with records at the West Midlands Cancer Intelligence Unit. Exclusion criteria used in National statistics were applied to this sample to quantify their impact on achieved interval cancer rates. The round lengths experienced by individual women at the unit were determined from the prevalent and incident invitation dates for 155 women with incident (re-screen) breast cancers detected in the second round. Setting— Warwickshire, Solihull and Coventry Breast Screening Unit. Subects—59 017 women screened between 17 April 1989 and 31 March 1992 with a negative screening result and 155 women with incident screen detected cancers. Results— A total of 278 interval cancers were identified, giving an overall rate from the prevalent screening round of 47.1/10 000 women screened. Of these, 213 met the criteria used in the definition of interval cancers for National statistics and were termed “core” interval cancers. The overall “core” interval rate was 36.1/10 000 women screened, similar to interval cancer rates found in the north west of United Kingdom. Thus applying commonly used exclusion criteria produced a 23.4% reduction in the apparent interval cancer rate, with the largest decrease resulting from the exclusion of cancers arising at 36 months or more from the last screen. Conclusions— The exclusion criteria used in the definition of interval cancers have a significant impact on observed interval cancer rates. Of particular concern is the exclusion in the current National definitions of cancers arising at 36 months or more from the last screen, which may mask a problem with significant implications for the success of the NHSBSP.

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Meta-analysis of prospective studies evaluating breast cancer detection and interval cancer rates for digital breast tomosynthesis versus mammography population screening

European Journal of Cancer ◽

10.1016/j.ejca.2021.01.035 ◽

2021 ◽

Vol 148 ◽

pp. 14-23

Author(s):

Nehmat Houssami ◽

Sophia Zackrisson ◽

Katrina Blazek ◽

Kylie Hunter ◽

Daniela Bernardi ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Detection ◽

Prospective Studies ◽

Meta Analysis ◽

Interval Cancer ◽

Digital Breast Tomosynthesis ◽

Population Screening ◽

Breast Cancer Detection ◽

Breast Tomosynthesis ◽

Cancer Rates

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The Impact of Educational Intervention Programs to Promoting Mammography Screening: A Systematic Review

Journal of Education and Community Health ◽

10.21859/jech-03018 ◽

2017 ◽

Vol 3 (1) ◽

pp. 58-67 ◽

Cited By ~ 1

Author(s):

Seyed Mohammad Mehdi Hazavehei ◽

Khadije Ezzati Rastegar ◽

Mitra Dogonchi ◽

Nooshin Salimi ◽

Elham Gheisvandi

Keyword(s):

Systematic Review ◽

Educational Intervention ◽

Mammography Screening ◽

Intervention Programs ◽

The Impact

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Systematic Review of Mammography Screening Educational Interventions for Hispanic Women in the United States

Journal of Cancer Education ◽

10.1007/s13187-018-1321-0 ◽

2018 ◽

Vol 34 (3) ◽

pp. 412-422 ◽

Cited By ~ 6

Author(s):

John S. Luque ◽

Ayaba Logan ◽

Grace Soulen ◽

Kent E. Armeson ◽

Danielle M. Garrett ◽

...

Keyword(s):

United States ◽

Systematic Review ◽

Mammography Screening ◽

Hispanic Women ◽

Educational Interventions ◽

The United States

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Impact of Full-Field Digital Mammography Versus Film-Screen Mammography in Population Screening: A Meta-Analysis

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/djaa080 ◽

2020 ◽

Vol 113 (1) ◽

pp. 16-26 ◽

Cited By ~ 1

Author(s):

Rachel Farber ◽

Nehmat Houssami ◽

Sally Wortley ◽

Gemma Jacklyn ◽

Michael L Marinovich ◽

...

Keyword(s):

Health Outcomes ◽

Cancer Detection ◽

Digital Mammography ◽

Meta Analysis ◽

Interval Cancer ◽

Population Screening ◽

Cancer Rate ◽

Screening Programs ◽

Interval Cancer Rate ◽

Cancer Rates

Abstract Background Breast screening programs replaced film mammography with digital mammography, and the effects of this practice shift in population screening on health outcomes can be measured through examination of cancer detection and interval cancer rates. Methods A systematic review and random effects meta-analysis were undertaken. Seven databases were searched for publications that compared film with digital mammography within the same population of asymptomatic women and reported cancer detection and/or interval cancer rates. Results The analysis included 24 studies with 16 583 743 screening examinations (10 968 843 film and 5 614 900 digital). The pooled difference in the cancer detection rate showed an increase of 0.51 per 1000 screens (95% confidence interval [CI] = 0.19 to 0.83), greater relative increase for ductal carcinoma in situ (25.2%, 95% CI = 17.4% to 33.5%) than invasive (4%, 95% CI = −3% to 13%), and a recall rate increase of 6.95 (95% CI = 3.47 to 10.42) per 1000 screens after the transition from film to digital mammography. Seven studies (80.8% of screens) reported interval cancers: the pooled difference showed no change in the interval cancer rate with −0.02 per 1000 screens (95% CI = −0.06 to 0.03). Restricting analysis to studies at low risk of bias resulted in findings consistent with the overall pooled results for all outcomes. Conclusions The increase in cancer detection following the practice shift to digital mammography did not translate into a reduction in the interval cancer rate. Recall rates were increased. These results suggest the transition from film to digital mammography did not result in health benefits for screened women. This analysis reinforces the need to carefully evaluate effects of future changes in technology, such as tomosynthesis, to ensure new technology leads to improved health outcomes and beyond technical gains.

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Analysis of proportional incidence and review of interval cancer cases observed within the mammography screening programme in Trento province, Italy

La radiologia medica ◽

10.1007/s11547-011-0711-8 ◽

2011 ◽

Vol 116 (8) ◽

pp. 1217-1225 ◽

Cited By ~ 10

Author(s):

M. Pellegrini ◽

D. Bernardi ◽

S. Di Michele ◽

P. Tuttobene ◽

C. Fantò ◽

...

Keyword(s):

Mammography Screening ◽

Screening Programme ◽

Interval Cancer ◽

Proportional Incidence

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Mammogram: Association of Music with Anxiety among Malaysian Woman – A Systematic Review.

European Journal of Medical and Health Sciences ◽

10.24018/ejmed.2020.2.2.237 ◽

2020 ◽

Vol 2 (2) ◽

Author(s):

Nur Fatin Ruslizam ◽

Nur Nadiah Fatihah Ab Malek ◽

Norhayati Mohd Zain ◽

Nur Anis Izzati Che Nut ◽

Norhashimah Mohd Norsuddin ◽

...

Keyword(s):

Breast Cancer ◽

Systematic Review ◽

Cancer Pain ◽

Music Therapy ◽

Mammography Screening ◽

Screening Tool ◽

Early Stage ◽

Database Search ◽

X Ray ◽

Detect Breast Cancer

Mammography is one of the screening tool that using x-ray dose to detect breast cancer at early stage for women older than 40 years old. By performing mammography screening annually, it can decrease mortality from breast cancer. Pain and anxiety often a hindrance to the rate of intake of mammography screening among the women. A systematic review was conducted to know the association of music with anxiety and pain on patients during mammography screening. Review identification was performed through a database search on MEDLINE and CINAHL, and 2 qualified studies were selected. The keyword used is “music therapy”, “anxiety”, ‘pain”, and “mammography”. A total of 2 articles showed the use of music among women who undergoing mammography screening. The previous studies showed that the use of music can decrease level of pain and anxiety among women during mammography screening. Thus, applying music during the screening should be implemented to encourage women for annual mammography screening.

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