Activated cytotoxic T cells and NK cells in severe sepsis and septic shock and their role in multiple organ dysfunction

2005 ◽  
Vol 116 (2) ◽  
pp. 158-165 ◽  
Author(s):  
S ZEERLEDER ◽  
C HACK ◽  
C CALIEZI ◽  
G VANMIERLO ◽  
A EERENBERGBELMER ◽  
...  
Keyword(s):  
Septic Shock ◽  
T Cells ◽  
Severe Sepsis ◽  
Nk Cells ◽  
Organ Dysfunction ◽  
Cytotoxic T Cells ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Sepsis And Septic Shock

Pharmacologic Treatment Related to Severe Sepsis

2006 ◽  
Vol 17 (4) ◽  
pp. 423-432
Author(s):  
Jan Powers ◽  
Judith Jacobi
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Organ Dysfunction ◽  
Mortality Rates ◽  
Multiple Organ ◽  
Pharmacologic Therapy ◽  
Multiple Organ Dysfunction ◽  
Challenging Problem ◽  
Care Nurse ◽  
Sepsis And Septic Shock

Severe sepsis is a complex syndrome often resulting in multiple organ dysfunction. This is an extremely challenging problem to manage in the intensive care unit, with mortality rates remaining at unacceptably high levels. Death of patients afflicted by this condition generally results from organ dysfunction syndromes related to hypoperfusion abnormalities. Management of patients with severe sepsis or septic shock can be very complex and challenging, utilizing a significant amount of resources. Pharmacologic support of patients with severe sepsis or septic shock primarily involves agents to support and improve perfusion at the microvascular level. It is important to understand the pharmacologic properties of the medications utilized to manage patients with these conditions. The information presented in this article is based on the best evidence currently available in order to assist the critical care nurse in understanding the pharmacologic therapy related to treatment of severe sepsis and septic shock.

scholarly journals 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study

Critical Care ◽  
2010 ◽  
Vol 14 (2) ◽  
pp. R79 ◽  
Author(s):  
Krisztina Madách ◽  
István Aladzsity ◽  
Ágnes Szilágyi ◽  
George Fust ◽  
János Gál ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Organ Dysfunction ◽  
Genetic Study ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Pai 1

scholarly journals Gas tonometry for evaluation of gastrointestinal mucosal perfusion: experimental and clinical sepsis¹. part 2

2002 ◽  
Vol 17 (5) ◽  
pp. 281-288 ◽  
Author(s):  
Eliezer Silva ◽  
Luiz Francisco Poli de Figueiredo ◽  
Ruy Jorge Cruz Jr ◽  
Maurício Rocha e Silva
Keyword(s):  
Septic Shock ◽  
Organ Dysfunction ◽  
Experimental Models ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Barrier Dysfunction ◽  
Clinical Sepsis ◽  
Mucosal Perfusion ◽  
Early Injury ◽  
Sepsis And Septic Shock

Substantial clinical and animal evidences indicate that the mesenteric circulatory bed, particularly the gut mucosa, is highly vulnerable to reductions in oxygen supply and prone to early injury in the course of hemodynamic changes induced by sepsis and septic shock. Gut hypoxia or ischemia is one possible contributing factor to gastrointestinal tract barrier dysfunction that may be associated with the development of systemic inflammatory response and multiple organ dysfunction syndrome, the principal cause of death after sepsis. Monitoring gut perfusion during experimental and clinical sepsis may provide valuable insights over new interventions and therapies highly needed to reduce multiple organ dysfunction and sepsis-related morbidity and mortality. We present our experience with gas tonometry as a monitor of the adequacy of gastrointestinal mucosal perfusion in experimental models sepsis and with the use of vasoactive agents for hemodynamic management in patients with septic shock.

scholarly journals The impact of duration of organ dysfunction on the outcome of patients with severe sepsis and septic shock

Clinics ◽  
2008 ◽  
Vol 63 (4) ◽  
Author(s):  
Flávio G. R. Freitas ◽  
Reinaldo Salomão ◽  
Nathalia Tereran ◽  
Bruno Franco Mazza ◽  
Murillo Assunção ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Organ Dysfunction ◽  
Sepsis And Septic Shock ◽  
The Impact

Nitric oxide (NO) production correlates with renal insufficiency and multiple organ dysfunction syndrome in severe sepsis

1996 ◽  
Vol 22 (11) ◽  
pp. 1197-1202 ◽  
Author(s):  
P. H. P. Groeneveld ◽  
K. M. C. Kwappenberg ◽  
J. A. M. Langermans ◽  
P. H. Nibbering ◽  
L. Curtis
Keyword(s):  
Nitric Oxide ◽  
Severe Sepsis ◽  
Renal Insufficiency ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Multiple Organ ◽  
No Production ◽  
Multiple Organ Dysfunction

Sepsis

2020 ◽  
Author(s):  
Steven P LaRosa ◽  
Steven M. Opal
Keyword(s):  
Intensive Care Unit ◽  
Septic Shock ◽  
Severe Sepsis ◽  
Intensive Care ◽  
Organ Dysfunction ◽  
Fluid Resuscitation ◽  
Multiorgan Failure ◽  
Sepsis Management ◽  
The Past ◽  
Sepsis And Septic Shock

Sepsis, along with the multiorgan failure that often accompanies this condition, is a leading cause of mortality in the intensive care unit. Although modest improvements in the prognosis have been made over the past two decades and promising new therapies continue to be investigated, innovations in the management of septic shock are still required. This chapter discusses the definitions, epidemiology, and pathogenesis (including microbial factors, host-derived mediators, and organ dysfunction) relating to sepsis. Management of severe sepsis and septic shock is also described.  This review contains 5 figures, 11 tables, and 99 references. Keywords:Organ dysfunction, sepsis, septic shock, infection, bacteremia, fluid resuscitation, vasopressor

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