T49. Motor cortical circuit interactions in Parkinson’s disease

2018 ◽  
Vol 129 ◽  
pp. e20
Author(s):  
James Saravanamuttu ◽  
Natasha Radhu ◽  
Kaviraja Udupa ◽  
Carolyn Gunraj ◽  
Julianne K. Baarbé ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cortical Circuit ◽  
Motor Cortical

scholarly journals Individual Magnetoencephalography Response Profiles to Short-Duration L-Dopa in Parkinson’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Edgar Peña ◽  
Tareq M. Mohammad ◽  
Fedaa Almohammed ◽  
Tahani AlOtaibi ◽  
Shahpar Nahrir ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Short Duration ◽  
Spectral Power ◽  
Clinical State ◽  
Support Vector ◽  
Learning Approaches ◽  
Factor Scores ◽  
Subject Specific ◽  
Motor Cortical

Clinical responses to dopamine replacement therapy for individuals with Parkinson’s disease (PD) are often difficult to predict. We characterized changes in MDS-UPDRS motor factor scores resulting from a short-duration L-Dopa response (SDR), and investigated how the inter-subject clinical differences could be predicted from motor cortical magnetoencephalography (MEG). MDS-UPDRS motor factor scores and resting-state MEG recordings were collected during SDR from twenty individuals with a PD diagnosis. We used a novel subject-specific strategy based on linear support vector machines to quantify motor cortical oscillatory frequency profiles that best predicted medication state. Motor cortical profiles differed substantially across individuals and showed consistency across multiple data folds. There was a linear relationship between classification accuracy and SDR of lower limb bradykinesia, although this relationship did not persist after multiple comparison correction, suggesting that combinations of spectral power features alone are insufficient to predict clinical state. Factor score analysis of therapeutic response and novel subject-specific machine learning approaches based on subject-specific neuroimaging provide tools to predict outcomes of therapies for PD.

scholarly journals Disruption of cortical dopaminergic modulation impairs preparatory activity and delays licking initiation

2018 ◽  
Author(s):  
Ke Chen ◽  
Roberto Vincis ◽  
Alfredo Fontanini
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Neural Activity ◽  
Cortical Activity ◽  
Motor Deficits ◽  
Receptor Modulation ◽  
Dopaminergic Modulation ◽  
Preparatory Activity ◽  
Motor Cortical

ABSTRACTDysfunction of motor cortices is thought to contribute to motor disorders such as Parkinson’s disease (PD). However, little is known on the link between cortical dopaminergic loss, abnormalities in motor cortex neural activity and motor deficits. We address the role of dopamine in modulating motor cortical activity by focusing on the anterior lateral motor cortex (ALM) of mice performing a cued-licking task. We first demonstrate licking deficits and concurrent alterations of spiking activity in ALM of mice with unilateral depletion of dopaminergic neurons (i.e., mice injected with 6-OHDA into the medial forebrain bundle). Hemi-lesioned mice displayed delayed licking initiation, shorter duration of licking bouts, and lateral deviation of tongue protrusions. In parallel with these motor deficits, we observed a reduction in the prevalence of cue responsive neurons and altered preparatory activity. Acute and local blockade of D1 receptors in ALM recapitulated some of the key behavioral and neural deficits observed in hemi-lesioned mice. Altogether, our data show a direct relationship between cortical D1 receptor modulation, cue-evoked and preparatory activity in ALM, and licking initiation.SIGNIFICANCE STATEMENTThe link between dopaminergic signaling, motor cortical activity and motor deficits is not fully understood. This manuscript describes alterations in neural activity of the anterior lateral motor cortex (ALM) that correlate with licking deficits in mice with unilateral dopamine depletion or with intra-ALM infusion of dopamine antagonist. The findings emphasize the importance of cortical dopaminergic modulation in motor initiation. These results will appeal not only to researchers interested in cortical control of licking, but also to a broader audience interested in motor control and dopaminergic modulation in physiological and pathological conditions. Specifically, our data suggest that dopamine deficiency in motor cortex could play a role in the pathogenesis of the motor symptoms of Parkinson’s disease.

scholarly journals Cerebellar Sensory Processing Alterations Impact Motor Cortical Plasticity in Parkinson's Disease: Clues from Dyskinetic Patients

2013 ◽  
Vol 24 (8) ◽  
pp. 2055-2067 ◽  
Author(s):  
A. Kishore ◽  
T. Popa ◽  
A. Balachandran ◽  
S. Chandran ◽  
S. Pradeep ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sensory Processing ◽  
Cortical Plasticity ◽  
Motor Cortical

People With Parkinson’s Disease Exhibit Reduced Cognitive and Motor Cortical Activity When Undertaking Complex Stepping Tasks Requiring Inhibitory Control

2020 ◽  
Vol 34 (12) ◽  
pp. 1088-1098
Author(s):  
Paulo H. S. Pelicioni ◽  
Stephen R. Lord ◽  
Yoshiro Okubo ◽  
Daina L. Sturnieks ◽  
Jasmine C. Menant
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Inhibitory Control ◽  
Near Infrared ◽  
Premotor Cortex ◽  
Cortical Activity ◽  
Cortical Activation ◽  
Functional Near Infrared Spectroscopy ◽  
Dorsolateral Prefrontal ◽  
Motor Cortical

Background People with Parkinson’s disease (PD) have difficulties generating quick and accurate steps in anticipation of and/or in response to environmental hazards. However, neural mechanisms underlying performance in cognitively demanding stepping tasks are unclear. Objective This study compared activation patterns in cognitive and motor cortical regions using functional near-infrared spectroscopy (fNIRS) between people with PD and age-matched healthy older adults (HOA) during stepping tasks. Methods Fifty-two people with PD and 95 HOA performed a simple choice stepping reaction time test (CSRT) and 2 cognitively demanding stepping tests (inhibitory CSRT [iCSRT] and Stroop stepping test [SST]) on a computerized step mat. Cortical activation in the dorsolateral prefrontal cortex (DLPFC), Broca’s area, supplementary motor area (SMA), and premotor cortex (PMC) were recorded using fNIRS. Stepping performance and cortical activity were contrasted between groups and between the CSRT and the iCSRT and SST. Results The PD group performed worse than the HOA in all 3 stepping tests. A consistent pattern of interactions indicated differential hemodynamic responses between the groups. Compared with the CSRT, the PD group exhibited reduced DLPFC activity in the iCSRT and reduced SMA and PMC activity in the SST. The HOA exhibited increased DLPFC, SMA, and PMC activity when performing the SST in comparison with the CSRT task. Conclusions In contrast to the HOA, the PD group demonstrated reduced cortical activity in the DLPFC, SMA, and PMC during the more complex stepping tasks requiring inhibitory control. This may reflect subcortical and/or multiple pathway damage with subsequent deficient use of cognitive and motor resources.

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