scholarly journals F154. Machine learning for the analysis of single pulse stimulation in electrocorticography

2018 ◽  
Vol 129 ◽  
pp. e125
Author(s):  
Emile d’Angremont ◽  
Geertjan J. Huiskamp ◽  
Frans S. Leijten ◽  
Christoph Brune ◽  
Michel J. van Putten
Keyword(s):  
Machine Learning ◽  
Single Pulse ◽  
Pulse Stimulation

scholarly journals Evaluation of Motor Neuron Excitability by CMAP Scanning with Electric Modulated Current

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Tiago Araújo ◽  
Rui Candeias ◽  
Neuza Nunes ◽  
Hugo Gamboa
Keyword(s):  
Compound Muscle Action Potential ◽  
Single Pulse ◽  
Response Amplitude ◽  
Stimulus Response ◽  
Response Slope ◽  
Biphasic Pulse ◽  
Muscle Action Potential ◽  
Motor Neuron Excitability ◽  
Peripheral Nerve Excitability ◽  
Pulse Stimulation

Introduction. Compound Muscle Action Potential (CMAP) scan is a noninvasive promissory technique for neurodegenerative pathologies diagnosis. In this work new CMAP scan protocols were implemented to study the influence of electrical pulse waveform on peripheral nerve excitability. Methods. A total of 13 healthy subjects were tested. Stimulation was performed with an increasing intensities range from 4 to 30 mA. The procedure was repeated 4 times per subject, using a different single pulse stimulation waveform: monophasic square and triangular and quadratic and biphasic square. Results. Different waveforms elicit different intensity-response amplitude curves. The square pulse needs less current to generate the same response amplitude regarding the other waves and this effect is gradually decreasing for the triangular, quadratic, and biphasic pulse, respectively. Conclusion. The stimulation waveform has a direct influence on the stimulus-response slope and consequently on the motoneurons excitability. This can be a new prognostic parameter for neurodegenerative disorders.

Sympatholytic response to stimulation of superior laryngeal nerve in rats

1991 ◽  
Vol 260 (2) ◽  
pp. R290-R297 ◽  
Author(s):  
D. H. Huangfu ◽  
P. G. Guyenet
Keyword(s):  
Receptor Antagonist ◽  
Superior Laryngeal Nerve ◽  
Single Pulse ◽  
Laryngeal Nerve ◽  
Ventrolateral Medulla ◽  
Gamma Aminobutyric Acid ◽  
Onset Latency ◽  
Medullary Reticular Formation ◽  
Pulse Stimulation ◽  
Stimulation Of

The central pathway mediating a sympatholytic response to stimulation of the superior laryngeal nerve (SLN) was studied in halothane-anesthetized, paralyzed rats. Single-pulse stimulation of SLN inhibited lumbar sympathetic nerve discharge (LSND) with onset latency of 113 +/- 1.7 ms. LSND inhibition was markedly attenuated by bilateral microinjection of kynurenic acid (Kyn, glutamate receptor antagonist, 4.5 nmol/side) into the caudal ventrolateral medulla (CVL) or by bilateral administration of bicuculline methiodide (Bic; gamma-aminobutyric acid-receptor antagonist, 225 pmol/side) into the rostral ventrolateral medulla (RVL). In 13 of 14 cases, the baroreceptor reflex was also severely reduced. Injections of Bic or Kyn elsewhere in the medullary reticular formation were ineffective. Single-pulse stimulation of SLN inhibited 19 of 26 RVL reticulospinal barosensitive cells (onset latency 46 +/- 1.4 ms). This inhibition was attenuated (from 92 +/- 6 to 14 +/- 12%) by iontophoretic application of Bic (n = 7), which also reduced the cells' inhibitory response to aortic coarctation. The remaining seven barosensitive neurons were unaffected by SLN stimulation. In conclusion, the sympathetic baroreflex and the sympathoinhibitory response to SLN stimulation appear to be mediated by similar medullary pathways.

Respiratory motor responses to cranial nerve afferent stimulation in rats

1996 ◽  
Vol 271 (4) ◽  
pp. R1054-R1062 ◽  
Author(s):  
F. Hayashi ◽  
D. R. McCrimmon
Keyword(s):  
Cranial Nerve ◽  
Superior Laryngeal Nerve ◽  
Single Pulse ◽  
Short Latency ◽  
Lung Inflation ◽  
Dorsal Respiratory Group ◽  
Inspiratory Activity ◽  
Pharyngeal Branch ◽  
Pulse Stimulation ◽  
Stimulation Of

It was hypothesized that, because rats appear to lack a prominent disynaptic projection from the dorsal respiratory group to phrenic motoneurons (Phr), they would lack the short-latency excitation of Phr output seen in cats in response to stimulation of some cranial nerve afferents. Single-pulse superior laryngeal nerve (SLN) stimulation elicited a short-latency bilateral excitation of glossopharyngeal (IX) and hypoglossal (XII) nerves and an ipsilateral excitation of pharyngeal branch of vagus (PhX) in 67% of rats, but no excitation of Phr. Vagus (X) stimulation elicited a bilateral excitation of Phr and a predominantly ipsilateral excitation of IX and PhX. Single-pulse stimulation of SLN or X also elicited longer-latency, bilateral decreases in activity of all recorded nerves. Repetitive stimulation (50 Hz) of SLN or X suppressed inspiratory activity and prolonged expiration. Lung inflation (7.5 cmH2O) inhibited Phr and PhX activity; X stimulation inhibited Phr but prolonged PhX activity. In conclusion, rats predictably lack the SLN-induced short latency Phr excitation but exhibit other short latency reflexes for which the underlying circuitry is not clear.

Electrical Pulse Train and Single Pulse Stimulation of the Small Intestine: Acute and Chronic Studies in the Dog

1989 ◽  
Vol 13 (2) ◽  
pp. 116-122 ◽  
Author(s):  
Anton Moritz ◽  
Sharon Grundfest-Broniatowski ◽  
Laszlo Ilyes ◽  
Jerry Kasick ◽  
Gordon Jacobs ◽  
...  
Keyword(s):  
Small Intestine ◽  
Pulse Train ◽  
Single Pulse ◽  
Electrical Pulse ◽  
Pulse Stimulation ◽  
Stimulation Of

Optical responses evoked by single-pulse stimulation to the dorsal root in the rat spinal dorsal horn in slice

1998 ◽  
Vol 812 (1-2) ◽  
pp. 81-90 ◽  
Author(s):  
Hiroshi Ikeda ◽  
Pan-Dong Ryu ◽  
Jin-Bong Park ◽  
Manabu Tanifuji ◽  
Tatsuya Asai ◽  
...  
Keyword(s):  
Dorsal Horn ◽  
Dorsal Root ◽  
Spinal Dorsal Horn ◽  
Single Pulse ◽  
Spinal Dorsal ◽  
Optical Responses ◽  
Pulse Stimulation

scholarly journals Abatement of epileptic spike-wave discharges through single pulse stimulation

2013 ◽  
Vol 14 (S1) ◽  
Author(s):  
Peter N Taylor ◽  
Yujiang Wang ◽  
Justin Dauwels ◽  
Gerold Baier
Keyword(s):  
Single Pulse ◽  
Spike Wave Discharges ◽  
Epileptic Spike ◽  
Pulse Stimulation ◽  
Spike Wave

Disynaptic Inhibition of Omnipause Neurons Following Electrical Stimulation of the Superior Colliculus in Alert Cats

2001 ◽  
Vol 85 (6) ◽  
pp. 2639-2642 ◽  
Author(s):  
Kaoru Yoshida ◽  
Yoshiki Iwamoto ◽  
Sohei Chimoto ◽  
Hiroshi Shimazu
Keyword(s):  
Superior Colliculus ◽  
Short Pulse ◽  
Single Pulse ◽  
Synaptic Organization ◽  
Postsynaptic Potentials ◽  
Disynaptic Inhibition ◽  
Alert Cats ◽  
Omnipause Neurons ◽  
Pulse Stimulation ◽  
Stimulation Of

We investigated the synaptic organization responsible for the inhibition of omnipause neurons (OPNs) following stimulation of the superior colliculus (SC) in alert cats. Stimulation electrodes were implanted bilaterally in the rostral and caudal SC where a short-pulse train induced small and large saccades, respectively. Effects of single-pulse stimulation on OPNs were examined with intracellular and extracellular recordings. In contrast to monosynaptic excitatory postsynaptic potentials, which were induced by rostral SC stimulation, inhibitory postsynaptic potentials were induced with disynaptic latencies (1.3–1.9 ms) from both the rostral and caudal SC in most OPNs. Analysis of a larger extracellular sample complemented intracellular observations. Monosynaptic activation of OPNs was elicited more frequently from rostral sites than from caudal sites, whereas spike suppression with disynaptic latencies was induced by caudal as well as rostral stimulation with similar frequencies. The results imply that disynaptic inhibition is produced by activation of SC cells that are distributed over wide regions related to saccades of different sizes. We suggest that signals from these neurons initiate a saccadic pause of OPNs through single inhibitory interneurons.

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