A Patient With Lung Adenocarcinoma With BRAF Gene Fusion and Response to Vemurafenib

2019 ◽  
Vol 20 (3) ◽  
pp. e224-e228
Author(s):  
You-cai Zhu ◽  
Wen-xian Wang ◽  
Chun-wei Xu ◽  
Wu Zhuang ◽  
Kai-qi Du ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Gene Fusion ◽  
Braf Gene

BRAF-MAD1L1 and BRAF-ZC3H7A: novel gene fusion in Rhabdomyosarcoma and Lung adenocarcinoma

2021 ◽  
Author(s):  
Jiang Da ◽  
Hui Jin ◽  
Xinliang Zhou ◽  
Shaoshuang Fan ◽  
Mian Xu ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Gene Fusion ◽  
Tumor Resection ◽  
Kinase Domain ◽  
Rapid Progression ◽  
First Line ◽  
Case Presentation ◽  
First Case ◽  
Exon 11 ◽  
Domain Exon

Abstract Background: Rhabdomyosarcoma (RMS) and lung adenocarcinoma (LADC) epitomizes the success of cancer prevention by the development of conventional therapy, but huge challenges remain in the therapy of advanced diseases.Case presentation: We reported two cases of novel BRAF gene fusion. The first case was a 34-year-old female with RMS harboring a BRAF-MAD1L1 fusion. She suffered tumor resection, recurrence and rapid progression. The second case was a 72-year-old female with LADC harboring a BRAF-ZC3H7A fusion, and she gained rapid progression after receiving a first-line course of chemotherapy.Conclusions: These two BRAF fusions retain the intact BRAF kinase domain (exon 11-18) and showed poor prognosis in RMS and LADC.

scholarly journals A new KIF5B-ERBB4 gene fusion in a lung adenocarcinoma patient

2021 ◽  
pp. 00582-2020
Author(s):  
Edouard Guenzi ◽  
Johan Pluvy ◽  
Alice Guyard ◽  
Marina Nguenang ◽  
Khedidja Rebah ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Gene Fusion ◽  
Lung Adenocarcinoma Patient ◽  
Erbb4 Gene

Excellent Response to MEK Inhibition in an AGK-BRAF Gene Fusion Driven Carcinoma: Case Report and Literature Review

2021 ◽  
Vol 42 (1) ◽  
pp. 373-379
Author(s):  
ANDREAS DOMEN ◽  
CARL VAN PAESSCHEN ◽  
KAREN ZWAENEPOEL ◽  
SUZAN LAMBIN ◽  
PATRICK PAUWELS ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Gene Fusion ◽  
Braf Gene ◽  
Mek Inhibition ◽  
Excellent Response

scholarly journals Evaluation of BRAF Gene Status in Gliomas

2021 ◽  
pp. 1-6
Author(s):  
Awadhesh Kumar Jaiswal ◽  
Awadhesh Kumar Jaiswal ◽  
Sarita Agrawal ◽  
Sushila Jaiswal ◽  
Kuntal Kanti Das ◽  
...  
Keyword(s):  
Pilocytic Astrocytoma ◽  
Gene Fusion ◽  
Prognostic Significance ◽  
Rt Pcr ◽  
Braf Gene ◽  
Who Grade ◽  
Reverse Transcription Pcr ◽  
Significant Difference ◽  
Braf Fusion ◽  
Gene Status

Background: Development of different molecular markers has given a new insight in the glioma management. KIAA1549-BRAF gene fusion has a diagnostic and prognostic significance. Aim: The aim of this study was to determine the KIAA1549-BRAF gene fusion in glioma and their correlation with various clinical parameters. Material and Methods: Forty cases of glioma were studied for KIAA1549-BRAF gene fusion by reverse transcription-PCR (RT-PCR). Results: Overall, KIAA1549-BRAF gene fusion was found in 22% (9/40) cases of glioma. Children had higher KIAA1549-BRAF fusion (72%; 8/11) as compared to adults (10%; 3/29) and this difference was statistically significant. Cerebellar location of tumor was significantly associated with KIAA1549-BRAF fusion. KIAA1549-BRAF fusion was highest in pilocytic astrocytoma (89%), and this difference was statistically significant. Statistically significant difference was noted between KIAA1549-BRAF fusion expression and WHO grade I glioma. Conclusion: Overall, KIAA1549-BRAF gene fusion was found in 22% (9/40) cases of glioma. Childhood age, pilocytic astrocytoma histology, cerebellar location and WHO grade I tumor were significantly associated with KIAA1549-BRAF gene fusion.

scholarly journals P07 Preliminary Orthogonal Analysis of EML4-ALK Gene Fusion Detection Methods in Chilean Patients with Lung Adenocarcinoma

2018 ◽  
Vol 13 (9) ◽  
pp. S163-S164
Author(s):  
M. Freire ◽  
R. Lizana ◽  
L. Ramos ◽  
G. Sepúlveda-Hermosilla ◽  
A. Blanco ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Gene Fusion ◽  
Detection Methods ◽  
Orthogonal Analysis ◽  
Fusion Detection

Chromosome arm 1q gain is an adverse prognostic factor in localized and diffuse leptomeningeal glioneuronal tumors with BRAF gene fusion and 1p deletion

2018 ◽  
Vol 137 (1) ◽  
pp. 179-181 ◽  
Author(s):  
Jason Chiang ◽  
James Dalton ◽  
Santhosh A. Upadhyaya ◽  
Zoltán Patay ◽  
Ibrahim Qaddoumi ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Gene Fusion ◽  
Braf Gene ◽  
Adverse Prognostic Factor ◽  
Chromosome Arm ◽  
1P Deletion ◽  
Glioneuronal Tumors ◽  
1Q Gain

scholarly journals A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing

2011 ◽  
Vol 22 (3) ◽  
pp. 436-445 ◽  
Author(s):  
Y. S. Ju ◽  
W.-C. Lee ◽  
J.-Y. Shin ◽  
S. Lee ◽  
T. Bleazard ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Transcriptome Sequencing ◽  
Gene Fusion ◽  
Whole Genome ◽  
Ret Gene

scholarly journals LGG-46. TRAMETINIB THERAPY IN PEDIATRIC PATIENTS WITH LOW-GRADE GLIOMAS (LGG) WITH BRAF GENE FUSION; A DISEASE-SPECIFIC COHORT IN THE FIRST PEDIATRIC TESTING OF TRAMETINIB

2018 ◽  
Vol 20 (suppl_2) ◽  
pp. i114-i114 ◽  
Author(s):  
Eric Bouffet ◽  
Mark Kieran ◽  
Darren Hargrave ◽  
Stephen Roberts ◽  
Isabelle Aerts ◽  
...  
Keyword(s):  
Gene Fusion ◽  
Pediatric Patients ◽  
Low Grade ◽  
Braf Gene ◽  
Low Grade Gliomas ◽  
Disease Specific
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