Anti-COVID-19 measures threaten our healthy body weight: Changes in sleep and external synchronizers of circadian clocks during confinement

Author(s):  
Luis Baquerizo-Sedano ◽  
J.A. Chaquila ◽  
Luis Aguilar ◽  
J.M. Ordovás ◽  
Pedro González-Muniesa ◽  
...  
2006 ◽  
Vol 76 (4) ◽  
pp. 208-215 ◽  
Author(s):  
Astrup

The epidemic of both obesity and type 2 diabetes is due to environmental factors, but the individuals developing the conditions possess a strong genetic predisposition. Observational surveys and intervention studies have shown that excess body fatness is the major environmental cause of type 2 diabetes, and that even a minor weight loss can prevent its development in high-risk subjects. Maintenance of a healthy body weight in susceptible individuals requires 45–60 minutes physical activity daily, a fat-reduced diet with plenty of fruit, vegetables, whole grain, and lean meat and dairy products, and moderate consumption of calorie containing beverages. The use of table values to predict the glycemic index of meals is of little – if any – value, and the role of a low-glycemic index diet for body weight control is controversial. The replacement of starchy carbohydrates with protein from lean meat and lean dairy products enhances satiety, and facilitate weight control. It is possible that dairy calcium also promotes weight loss, although the mechanism of action remains unclear. A weight loss of 5–10% can be induced in almost all obese patients providing treatment is offered by a professional team consisting of a physician and dieticians or nurses trained to focus on weight loss and maintenance. Whereas increasing daily physical activity and regular exercise does not significantly effect the rate of weight loss in the induction phase, it plays an important role in the weight maintenance phase due to an impact on daily energy expenditure and also to a direct enhancement of insulin sensitivity.


Obesity ◽  
2019 ◽  
Vol 27 (3) ◽  
pp. 462-469
Author(s):  
Bin Dong ◽  
Yan-Hui Dong ◽  
Zhao-Geng Yang ◽  
Xi-Jie Wang ◽  
Zhi-Yong Zou ◽  
...  

2021 ◽  
pp. 114015
Author(s):  
Lisanne S. Mulderij ◽  
José Ignacio Hernández ◽  
dr.mr. Niek Mouter ◽  
dr. Kirsten T. Verkooijen ◽  
dr.ir. Annemarie Wagemakers

1980 ◽  
Vol 95 (1) ◽  
pp. 39-45
Author(s):  
I. D. McArthur

SummaryA survey of sheep production was undertaken in rangeland areas of western Afghanistan to provide basic information of ewe body-weight changes throughout the year and on production variables, including mortality and lambing performance. Ewes lost up to 31% of body weight between December and March and mortality over the same period was 7%. On the basis of the results of this survey, an experiment was made to test the effect on lambing performance of pre-lambing supplementation of range-based ewes.Supplementation reduced weight losses in ewes, but the feeding treatments did not produce significant results in terms of lamb birth weights or survival to 10 days. However, there were indications that selective feeding of weak ewes can produce economic benefits, given that the costs of supervising such animals are minimal and the price of grain supplements is low relative to the price of meat.


2009 ◽  
Vol 202 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Kikuko Hotta ◽  
Masahiro Hosaka ◽  
Atsushi Tanabe ◽  
Toshiyuki Takeuchi

Functional variations in the secretogranin III (SCG3) gene are associated with susceptibility to obesity. SCG3 forms secretory granules with orexin, melanin-concentrating hormone (MCH), neuropeptide Y (NPY), and POMC in the hypothalamus. In this study, we screened proteins for SCG3-binding activity and identified secretogranin II (SCG2) using a yeast two-hybrid system. Immunoprecipitation revealed that SCG2 interacts with SCG3. In situ hybridization and immunohistochemistry indicated that SCG2 was highly expressed in the lateral hypothalamic area, paraventricular nucleus, and arcuate nucleus of the hypothalamus. Double-labeling immunohistochemical analysis demonstrated that SCG2 was expressed in orexin-, MCH-, NPY-, and POMC-expressing neurons. SCG2 was also coexpressed with SCG3. Upon introduction into neuroblastoma cells, SCG2 was expressed in the cytosol and formed granule-like structures with SCG3, orexin, NPY, or POMC. SCG3 bound to POMC; however, it did not bind to orexin, MCH, or NPY. By contrast, SCG2 formed aggregates with orexin, MCH, NPY, and POMC. SCG2 may act as a hormone carrier for orexin, MCH, NPY, and POMC by binding with SCG3, which targets proteins to the secretory granules. SCG2 mRNA levels increased along with those of SCG3, orexin, MCH, and NPY after a 24-h fast, suggesting that the SCG2/SCG3 system may respond in an adaptive manner to acute body weight changes. However, this SCG2/SCG3 system appears to be unresponsive to chronic body weight changes, such as diet-induced obesity or obesity in ob/ob mice. We suggest that SCG2, as well as SCG3, may be a potential regulator of food intake based on its capacity to accumulate appetite-related hormones into secretory granules.


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