The Effect of Hematocrit and Nanoparticles Diameter on Hemodynamic Parameters and Drug Delivery in Abdominal Aortic Aneurysm with Consideration of Blood Pulsatile Flow

2020 ◽  
Vol 195 ◽  
pp. 105545 ◽  
Author(s):  
Sina Jafarzadeh ◽  
Arsalan Nasiri Sadr ◽  
Ehsan Kaffash ◽  
Sahar Goudarzi ◽  
Ehsan Golab ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Pulsatile Flow ◽  
Hemodynamic Parameters ◽  
Abdominal Aortic

Fluid-Structure Interactions Abdominal Aortic Aneurysm Models Under the Pulsatile Flow Condition

2000 ◽  
Author(s):  
Chi-Ho Kwon ◽  
Ki-Won Lee ◽  
Young-Ho Kim
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Wall Thickness ◽  
Pulsatile Flow ◽  
Flow Condition ◽  
Fluid Structure Interactions ◽  
Fluid Structure ◽  
Aneurysm Wall ◽  
Abdominal Aortic ◽  
Human Cardiovascular System

Abstract Fluid-structure interaction studies were performed on various abdominal aortic aneurysm (AAA) models under the pulsatile flow condition. Eight aneurysm models were made with four different dilatation sizes and two different wall thickness. Stresses and deformations of the aneurysm wall were significantly affected by the dilatation size as well as the wall thickness. The change in wall thickness increased with the more dilated aneurysm. In spite of considerable radial deformations, axial deformations of the aneurysm wall were dominant. The present study showed the strong possibility to understand fluid-structure interactions in the human cardiovascular system.

A COMPUTATIONAL STUDY ON AXISYMMETRIC ABDOMINAL AORTIC ANEURYSM MODELS USING FLUID-STRUCTURE INTERACTIONS UNDER PULSATILE FLOW CONDITIONS

2002 ◽  
Vol 02 (03n04) ◽  
pp. 211-230 ◽  
Author(s):  
YOUNG-HO KIM
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Shear Rate ◽  
Aortic Aneurysm ◽  
Pressure Gradient ◽  
Pulsatile Flow ◽  
Distal Region ◽  
Wall Shear Rate ◽  
Aneurysm Wall ◽  
Abdominal Aortic ◽  
Wall Shear

Fluid-structure interaction study was performed on various abdominal aortic aneurysm (AAA) models under the pulsatile flow condition. Eight aneurysm models were made with four different dilatation sizes and two different wall thickness. Von Mises stress increased at the proximal and distal region (± 1D) of the aneurysm as well as the maximum dilatation, where both change in diameter and radial movement were larger than any other site with more dilated models. In spite of considerable radial movements, axial movements of the aneurysm wall were dominant and were larger in the proximal region of the aneurysm than in the distal region of the aneurysm. Wall shear rate, in general, increased further for uniform wall thickness models and for less dilated models, which means that wall shear rate is closely related to the motion of the wall. We confirmed the phase delay between the pressure gradient and wall shear rate. Throughout the entire pulsatile cycle, a weak recirculating vortex near the proximal end moved further distally in the aneurysm with increase in size and strength. Larger and stronger vortex was dominant inside the aneurysm with more dilated models and decelerating pressure gradient had a relatively stronger effect on the flow.

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