Dual temperature/pH-sensitive drug delivery of poly(N-isopropylacrylamide-co-acrylic acid) nanogels conjugated with doxorubicin for potential application in tumor hyperthermia therapy

2011 ◽  
Vol 84 (2) ◽  
pp. 447-453 ◽  
Author(s):  
Wei Xiong ◽  
Wei Wang ◽  
Yi Wang ◽  
Yanbing Zhao ◽  
Huabing Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Acrylic Acid ◽  
Potential Application ◽  
Ph Sensitive ◽  
Hyperthermia Therapy ◽  
Tumor Hyperthermia

Radiation synthesis of pH-sensitive hydrogels from β-cyclodextrin-grafted PEG and acrylic acid for drug delivery

2009 ◽  
Vol 116 (1) ◽  
pp. 148-152 ◽  
Author(s):  
Jie Chen ◽  
Liang Rong ◽  
Han Lin ◽  
Ruijia Xiao ◽  
Huifeng Wu
Keyword(s):  
Drug Delivery ◽  
Acrylic Acid ◽  
Ph Sensitive ◽  
Radiation Synthesis

Thermosensitive Poloxamer 407/Poly(Acrylic Acid) Hydrogels with Potential Application as Injectable Drug Delivery System

2018 ◽  
Vol 19 (5) ◽  
pp. 2103-2117 ◽  
Author(s):  
Wannisa Boonlai ◽  
Vimon Tantishaiyakul ◽  
Namon Hirun ◽  
Tanatchaporn Sangfai ◽  
Krit Suknuntha
Keyword(s):  
Drug Delivery ◽  
Acrylic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Potential Application ◽  
Poloxamer 407 ◽  
Injectable Drug ◽  
Poly Acrylic Acid

Synthesis of a novel pH responsive phyllosilicate loaded polymeric hydrogel based on poly(acrylic acid-co-N-vinylpyrrolidone) and polyethylene glycol for drug delivery: modelling and kinetics study for the sustained release of an antibiotic drug

RSC Advances ◽  
2015 ◽  
Vol 5 (24) ◽  
pp. 18312-18327 ◽  
Author(s):  
Sayan Ganguly ◽  
Narayan C. Das
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Acrylic Acid ◽  
Sustained Release ◽  
Ph Sensitive ◽  
Kinetics Study ◽  
Ph Responsive ◽  
Polymeric Network ◽  
Antibiotic Drug ◽  
Poly Acrylic Acid

In this study, we developed a novel pH-sensitive composite interpenetrating polymeric network (IPN) hydrogel based on polyethylene gylcol (PEG) and poly(acrylic acid-co-N-vinylpyrrolidone) crosslinked with N,N-methylenebisacrylamide (MBA).

scholarly journals Development of pH-Sensitive Chitosan-g-poly(acrylamide-co-acrylic acid) Hydrogel for Controlled Drug Delivery of Tenofovir Disoproxil Fumarate

Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3571
Author(s):  
Justin B. Safari ◽  
Alain M. Bapolisi ◽  
Rui W. M. Krause
Keyword(s):  
Drug Delivery ◽  
Ionic Strength ◽  
Hepatitis B ◽  
Acrylic Acid ◽  
Tenofovir Disoproxil Fumarate ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Cytotoxicity Studies ◽  
Hela Cell Lines ◽  
Poly Acrylamide

The present study aimed to develop a pH-sensitive chitosan-based hydrogel for controlled delivery of an anti-hepatitis B drug, tenofovir disoproxil fumarate (TDF). Free radical polymerization was utilized to graft acrylamide and acrylic acid using N,N-methylene bisacrylamide as the crosslinker. Physicochemical characterization confirmed the synthesis of thermally stable chitosan-g-poly(acrylamide-co-acrylic acid) hydrogels with well-defined pores within a fibrous surface. The prepared hydrogels exhibited pH and ionic strength sensitivity, with the swelling significantly lower under acidic and strong ionic strength conditions but higher in neutral and basic solutions. In addition, cytotoxicity studies on HeLa cell lines proved the cytocompatibility of the drug delivery material and its readiness for physiological applications. The encapsulation of TDF in the hydrogels was optimized and an encapsulation efficiency and a drug loading percentage of 96% and 10% were achieved, respectively. More interestingly, in vitro release studies demonstrated a pH-dependent release of TDF from hydrogels. The release at pH 7.4 was found to be up to five times higher than at pH 1.2 within 96 h. This further suggested that the newly developed hydrogel-loaded TDF could be proposed as a smart delivery system for oral delivery of anti-hepatitis B drugs.

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