An intelligent dual stimuli-responsive photosensitizer delivery system with O2-supplying for efficient photodynamic therapy

Photodynamic therapy (PDT) is an effective, noninvasive and nontoxic therapeutics for cancer and some other diseases. It is becoming a alternative of traditional therapeutics for cancers. But the efficacy of PDT was restricted by insufficient selectivity and low solubility. In this study, novel multifunctional silica-based magnetic nanoparticles were prepared as targeting drug delivery system to achieve higher specificity and better solubility. Haematoporphyrin derivative (photosan) was used as photosensitizer. Magnetite nanoparticles (Fe3O4) and photosan were incorporated in silica nanoparticles by microemulsion and sol-gel methods. The prepared nanoparticles were characterized by X-ray diffraction, and transmission electron microscopy. The nanoparticles possessed good biocompatibility and could cause remarkable photodynamic anti-tumor effects. These suggested that photosan-Fe3O4 nanoparticles had great potential as effective drug delivery system in targeting photodynamic therapy.

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Schiff base-containing dextran nanogel as pH-sensitive drug delivery system of doxorubicin: Synthesis and characterization

Journal of Biomaterials Applications ◽

10.1177/0885328218783969 ◽

2018 ◽

Vol 33 (2) ◽

pp. 170-181 ◽

Cited By ~ 13

Author(s):

Hongying Su ◽

Wen Zhang ◽

Yayun Wu ◽

Xiaodong Han ◽

Gang Liu ◽

...

Keyword(s):

Drug Delivery ◽

Schiff Base ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Ph Sensitive ◽

Cell Uptake ◽

Stimuli Responsive ◽

Drug Release Profile

Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2.0, 5.0) than that at pH 7.4. Approximately 66, 28, and 9% of drug was released in 72 h at pH 2.0, 5.0, and 7.4, respectively. Cell uptake by the human breast cancer cell (MCF-7) demonstrated that the DOX-loaded dextran nanogel could be internalized through endocytosis and distributed in endocytic compartments inside tumor cells. These results indicated that the Schiff base-containing nanogel can serve as a pH-sensitive drug delivery system. And the presence of multiple aldehyde groups on the nanogel are available for further conjugations of targeting ligands or imaging probes.

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Dual-responsive nanoplatform with feedback amplification improves antitumor efficacy of photodynamic therapy

Nanoscale ◽

10.1039/d1nr06875j ◽

2022 ◽

Author(s):

Yuan Xue ◽

Shuting Bai ◽

Leilei Wang ◽

Shi Luo ◽

Zhirong Zhang ◽

...

Keyword(s):

Photodynamic Therapy ◽

Side Effects ◽

Tumor Cells ◽

Delivery System ◽

Antitumor Efficacy ◽

Tumor Uptake ◽

Dual Responsive ◽

Intracellular Release ◽

Enhance Efficiency

A good photosensitizer (PS) delivery system could enhance efficiency and reduce side effects of anti-tumor photodynamic therapy (PDT) by improving accumulation in tumor, uptake by tumor cells, and intracellular release...

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Dual-Stimuli-Responsive Polypeptide Nanoparticles for Photothermal and Photodynamic Therapy

ACS Applied Bio Materials ◽

10.1021/acsabm.9b00964 ◽

2019 ◽

Vol 3 (1) ◽

pp. 561-569 ◽

Cited By ~ 6

Author(s):

Peiyu Zhang ◽

Zhiliang Gao ◽

Jiwei Cui ◽

Jingcheng Hao

Keyword(s):

Photodynamic Therapy ◽

Stimuli Responsive

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Dual-responsive polyphosphazene as a common platform for highly efficient drug self-delivery

Journal of Materials Chemistry B ◽

10.1039/c9tb00801b ◽

2019 ◽

Vol 7 (27) ◽

pp. 4319-4327 ◽

Cited By ~ 4

Author(s):

Sheng-Lei Hou ◽

Shuang-Shuang Chen ◽

Zhang-Jun Huang ◽

Qing-Hua Lu

Keyword(s):

Drug Release ◽

Delivery System ◽

Cancer Chemotherapy ◽

Stimuli Responsive ◽

Highly Efficient ◽

Dual Responsive ◽

Common Platform

A drug self-framed delivery system (DSFDS) with dual-stimuli-responsive drug release and superhigh drug loaded capacity for efficient cancer chemotherapy is proposed.

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