Researches on Preparation of Photosan Loaded Magnetic Silica Anoparticles and their Anti-Tumor Effects in Photodynamic Therapy

2012 ◽  
Vol 622-623 ◽  
pp. 821-826
Author(s):  
Yu Wen ◽  
Xiao Feng Deng ◽  
Liang Liang Liu ◽  
Shu Yun Shi ◽  
Li Xiong
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Sol Gel ◽  
Haematoporphyrin Derivative ◽  
X Ray Diffraction ◽  
Transmission Electron ◽  
Good Biocompatibility ◽  
Low Solubility

Photodynamic therapy (PDT) is an effective, noninvasive and nontoxic therapeutics for cancer and some other diseases. It is becoming a alternative of traditional therapeutics for cancers. But the efficacy of PDT was restricted by insufficient selectivity and low solubility. In this study, novel multifunctional silica-based magnetic nanoparticles were prepared as targeting drug delivery system to achieve higher specificity and better solubility. Haematoporphyrin derivative (photosan) was used as photosensitizer. Magnetite nanoparticles (Fe3O4) and photosan were incorporated in silica nanoparticles by microemulsion and sol-gel methods. The prepared nanoparticles were characterized by X-ray diffraction, and transmission electron microscopy. The nanoparticles possessed good biocompatibility and could cause remarkable photodynamic anti-tumor effects. These suggested that photosan-Fe3O4 nanoparticles had great potential as effective drug delivery system in targeting photodynamic therapy.

scholarly journals Development and Evaluation of Docetaxel-Phospholipid Complex Loaded Self-Microemulsifying Drug Delivery System: Optimization and In Vitro/Ex Vivo Studies

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 544
Author(s):  
Miao Wang ◽  
Sung-Kyun You ◽  
Hong-Ki Lee ◽  
Min-Gu Han ◽  
Hyeon-Min Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Anticancer Agents ◽  
Lipid Membrane ◽  
Ex Vivo ◽  
System Optimization ◽  
Raw Material ◽  
Phospholipid Complex ◽  
Low Solubility

Docetaxel (DTX) has clinical efficacy in the treatment of breast cancer, but it is difficult to develop a product for oral administration, due to low solubility and permeability. This study focused on preparing a self-microemulsifying drug delivery system (SME) loaded with DTX-phospholipid complex (DTX@PLC), to improve the dissolution and gastrointestinal (GI) permeability of DTX. A dual technique combining the phospholipid complexation and SME formulation described as improving upon the disadvantages of DTX has been proposed. We hypothesized that the complexation of DTX with phospholipids can improve the lipophilicity of DTX, thereby increasing the affinity of the drug to the cell lipid membrane, and simultaneously improving permeability through the GI barrier. Meanwhile, DTX@PLC-loaded SME (DTX@PLC-SME) increases the dissolution and surface area of DTX by forming a microemulsion in the intestinal fluid, providing sufficient opportunity for the drug to contact the GI membrane. First, we prepared DTX@PLC-SME by combining dual technologies, which are advantages for oral absorption. Next, we optimized DTX@PLC-SME with nanosized droplets (117.1 nm), low precipitation (8.9%), and high solubility (33.0 mg/g), which formed a homogeneous microemulsion in the aqueous phase. Dissolution and cellular uptake studies demonstrated that DTX@PLC-SME showed 5.6-fold higher dissolution and 2.3-fold higher DTX uptake in Caco-2 cells than raw material. In addition, an ex vivo gut sac study confirmed that DTX@PLC-SME improved GI permeability of DTX by 2.6-fold compared to raw material. These results suggested that DTX@PLC-SME can significantly overcome the disadvantages of anticancer agents, such as low solubility and permeability.

scholarly journals Bioactive Glass as a Nanoporous Drug Delivery System for Teicoplanin

2020 ◽  
Vol 10 (7) ◽  
pp. 2595 ◽  
Author(s):  
Chih-Ling Huang ◽  
Wei Fang ◽  
Bo-Rui Huang ◽  
Yan-Hsiung Wang ◽  
Guo-Chung Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Drug Delivery System ◽  
Delivery System ◽  
Inductively Coupled Plasma ◽  
High Performance ◽  
Ph Value ◽  
Sol Gel ◽  
Phase Identification ◽  
Bet Analysis

Bioactive glass (BG) was made by the sol–gel method and doped with boron (B) to increase its bioactivity. Microstructures of BG and B-doped BG were observed by scanning electron microscopy, and phase identification was performed using an X-ray diffraction diffractometer. The ion concentrations released after soaking in simulated body fluid (SBF) for 1, 4, and 7 days were measured by inductively coupled plasma mass spectrometry, and the pH value of the SBF was measured after soaking samples to determine the variation in the environment. Brunauer–Emmett–Teller (BET) analysis was performed to further verify the characteristics of mesoporous structures. High performance liquid chromatography was used to evaluate the drug delivery ability of teicoplanin. Results demonstrated that B-doped BG performed significantly better than BG in parameters assessed by the BET analysis. B-doped BG has nanopores and more rough structures, which is advantageous for drug delivery as there are more porous structures available for drug adsorption. Moreover, B-doped BG was shown to be effective for keeping pH values stable and releasing B ions during soaking in SBF. The cumulative release of teicoplanin from BG and B-doped BG reached 20.09% and 3.17% on the first day, respectively. The drug release gradually slowed, reaching 29.43% and 4.83% after 7 days, respectively. The results demonstrate that the proposed bioactive glass has potential as a drug delivery system.

REVIEW ON GASTRORETENTIVE DRUG DELIVERY SYSTEM

2020 ◽  
pp. 38-45
Author(s):  
MANDAR J BHANDWALKAR ◽  
PRASAD S DUBAL ◽  
AKASH K.TUPE ◽  
SUPRIYA N MANDRUPKAR
Keyword(s):  
Drug Delivery ◽  
Small Intestine ◽  
Drug Delivery System ◽  
Residence Time ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Oral Drug ◽  
Low Solubility

In recent years, gastroretentive drug delivery system (GRDDS) has gained researcher’s interest in the field of oral drug delivery. Various GRDDS approaches can be utilized to retain the dosage forms in the stomach and to release the drug slowly for an extended period of time. GRDDS can be used to prolong the residence time of delivery system in the stomach. This results in targeting of drug release at a specific site for the systemic or local effects. GRDDS can be used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. The challenges include fast gastric emptying of the dosage form which results in the poor bioavailability of the drug. Prolongation of the retention of drugs in stomach those having low solubility at high intestinal pH improves the solubility of drugs. GRDDS has proved to be effective in systemic actions as well as in local actions to treat gastric or duodenal ulcers. Local activity in the upper part of the small intestine can be obtained by improving the residence time of delivery system in the stomach. The system is useful for drugs which are unstable in the intestine or having a low solubility/permeability in the small intestine. Various GRDDS approaches include high density (sinking) systems, low-density (floating systems), mucoadhesive, expandable, unfoldable, superporous hydrogel systems, and magnetic systems.

scholarly journals RECENT NANOCOCHLEATE DRUG DELIVERY SYSTEM FOR CANCER TREATMENT: A REVIEW

2019 ◽  
pp. 28-32
Author(s):  
SUJIT NAYEK ◽  
ABHIRAMI VENKATACHALAM ◽  
SANGEETA CHOUDHURY
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Divalent Cation ◽  
Technology Use ◽  
Oral Bioavailability ◽  
Anticancer Agent ◽  
Low Permeability ◽  
Delivery Mechanism ◽  
Low Solubility

Nanocochleates are at the forefront of the fast-growing nanotechnology sector in the delivery of drugs for cancer. This nanotechnology is the use of the cationic and anionic encapsulated drug that has poor oral bioavailability. Nanocochleate is a lipid-based drug delivery in the liposomal vesicles that is converted by calcium divalent cation into nanocochleate. Nanocochleates technology use encapsulations of the anticancer agent, which have low solubility, oral bioavailability and low permeability. This paper shows and provides an overview of the benefits of nanocochleates, drug delivery mechanism, choice of prevalent components (Phospholipids and Cations), various ways of producing nanocochleates and nanocochleate stability. Nanocochleates have far fewer constraints than other traditional carriers. To characterize nanocochleates, the suitable analytical methods are required. Therefore, in the therapy of cancer, nanocochleate becomes commonly applied and more prospective drug delivery system.

Ionogels as drug delivery system: one-step sol–gel synthesis using imidazolium ibuprofenate ionic liquid

2010 ◽  
Vol 46 (2) ◽  
pp. 228-230 ◽  
Author(s):  
Lydie Viau ◽  
Corine Tourné-Péteilh ◽  
Jean-Marie Devoisselle ◽  
André Vioux
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Sol Gel ◽  
One Step ◽  
Sol Gel Synthesis

scholarly journals Enhanced effect of photodynamic therapy in ovarian cancer using a nanoparticle drug delivery system

2015 ◽  
Vol 47 (3) ◽  
pp. 1070-1076 ◽  
Author(s):  
ZHAO LI ◽  
LIPING SUN ◽  
ZAIJUN LU ◽  
XUANTAO SU ◽  
QIFENG YANG ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nanoparticle Drug Delivery

Magnetic nanoemulsions as drug delivery system for Foscan®: Skin permeation and retention in vitro assays for topical application in photodynamic therapy (PDT) of skin cancer

2007 ◽  
Vol 311 (1) ◽  
pp. 354-357 ◽  
Author(s):  
Fernando L. Primo ◽  
Leandro Michieleto ◽  
Marcilene A.M. Rodrigues ◽  
Patrícia P. Macaroff ◽  
Paulo C. Morais ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Skin Cancer ◽  
Drug Delivery System ◽  
Delivery System ◽  
Topical Application ◽  
Skin Permeation ◽  
In Vitro Assays
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