scholarly journals Particle-stabilized oil-in-water emulsions as a platform for topical lipophilic drug delivery

2021 ◽  
Vol 197 ◽  
pp. 111423
Author(s):  
Suphatra Hiranphinyophat ◽  
Akihisa Otaka ◽  
Yuta Asaumi ◽  
Syuji Fujii ◽  
Yasuhiko Iwasaki
Keyword(s):  
Drug Delivery ◽  
Lipophilic Drug ◽  
Oil In Water

scholarly journals Uji Stabilitas Sediaan Mikroemulsi Menggunakan Hidrolisat Pati (DE 35–40) Sebagai Stabilizer

2006 ◽  
Vol 3 (1) ◽  
pp. 8-21
Author(s):  
Mahdi Jufri ◽  
◽  
Effionora Anwar ◽  
Putri Margaining Utami
Keyword(s):  
Drug Delivery ◽  
Dosage Form ◽  
Tween 80 ◽  
Microemulsion System ◽  
Hydrophobic Drug ◽  
Dextrose Equivalent ◽  
Oil In Water ◽  
External Phase ◽  
The Stability ◽  
Made In

Various solubilization techniques have been developed to enhance the bioavailability of hydrophobic drugs. One of the solubilization techniques is preparation of microemulsion. Microemulsion is a potential carrier in drug delivery system because it has many advantageous characteristics. In this research, hydrophobic drug was made in a dosage form of oil in water (O/W) microemulsion using ketoprofen as a model and investigated the influence of adding starch hydrolisates with dextrose equivalent (DE) 35-40 in variety concentrations (0,0%; 1,5%; 2,0%; 2,5%) to the stability of this microemulsion system. This microemulsion consisted of isopropyl miritate as oil phase, tween 80 and lechitin as surfactants, ethanol as cosurfactant, propylene glycol as cosolvent, starch hydrolisates DE 35–40 as stabilizer, and water as external phase. The evaluation was stability test both phisically and chemically. The result showed that the stability of microemulsion system increased significantly by adding starch hydrolisates DE 35-40 at 2,5%.

Natural polymer-stabilized multiple water-in-oil-in-water emulsions: a novel dermal drug delivery system for 5-fluorouracil

2013 ◽  
Vol 66 (5) ◽  
pp. 658-667 ◽  
Author(s):  
Magdalena Hoppel ◽  
Denise Mahrhauser ◽  
Christina Stallinger ◽  
Florian Wagner ◽  
Michael Wirth ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Natural Polymer ◽  
Oil In Water ◽  
Dermal Drug Delivery ◽  
Polymer Stabilized

Oleosome: A novel carrier for drug delivery, its stability issues, probable approaches for their stabilization, and associated Patents in Pharmaceutical Field

2021 ◽  
Vol 15 ◽  
Author(s):  
Sumel Ashique ◽  
Ajmer Singh ◽  
Navjot K Sandhu
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Sustained Release ◽  
Biological System ◽  
Formulation Development ◽  
Natural Origin ◽  
Lipophilic Drug ◽  
The Core ◽  
Film Forming ◽  
Stability Issues

: Oleosomes are oil containing micro-carriers of natural origin that is comprised of special Oleosin proteins embedded with a monolayer of phospholipids and having triacylglycerol core. Due to their unique structure and non-toxic to the biological system these oil carriers are becoming very eye-catching in the field of formulation development in the field of pharmacy. Consequently, it offers emoliency, occlusivity, self-emulsification, an antioxidant and film-forming property which leads to controlled and sustained release of encapsulated bio-actives. It is also feasible to load oil-soluble ingredients such as fragrance, vitamins (retinol), and lipophilic drug moieties inside the core. Being a natural carrier, it shows some stability issues (leakage of oil from the core, oxidation of the loaded oil, aggregation of oil droplets) which are controllable. In this review, we have focused on the various stability issues, techniques (coating, surface modification, solvents) to overcome those problems, how to load any lipophilic drug into the oil core, and linked patent research works in the field of formulation development.

Sign in / Sign up

Export Citation Format

Share Document