Tuning Hyperparameters of Machine Learning Algorithms and Deep Neural Networks Using Metaheuristics: A Bioinformatics Study on Biomedical and Biological Cases

Author(s):  
Sajjad Nematzadeh ◽  
Farzad Kiani ◽  
Mahsa Torkamanian-Afshar ◽  
Nizamettin Aydin
Author(s):  
E. Yu. Shchetinin

The recognition of human emotions is one of the most relevant and dynamically developing areas of modern speech technologies, and the recognition of emotions in speech (RER) is the most demanded part of them. In this paper, we propose a computer model of emotion recognition based on an ensemble of bidirectional recurrent neural network with LSTM memory cell and deep convolutional neural network ResNet18. In this paper, computer studies of the RAVDESS database containing emotional speech of a person are carried out. RAVDESS-a data set containing 7356 files. Entries contain the following emotions: 0 – neutral, 1 – calm, 2 – happiness, 3 – sadness, 4 – anger, 5 – fear, 6 – disgust, 7 – surprise. In total, the database contains 16 classes (8 emotions divided into male and female) for a total of 1440 samples (speech only). To train machine learning algorithms and deep neural networks to recognize emotions, existing audio recordings must be pre-processed in such a way as to extract the main characteristic features of certain emotions. This was done using Mel-frequency cepstral coefficients, chroma coefficients, as well as the characteristics of the frequency spectrum of audio recordings. In this paper, computer studies of various models of neural networks for emotion recognition are carried out on the example of the data described above. In addition, machine learning algorithms were used for comparative analysis. Thus, the following models were trained during the experiments: logistic regression (LR), classifier based on the support vector machine (SVM), decision tree (DT), random forest (RF), gradient boosting over trees – XGBoost, convolutional neural network CNN, recurrent neural network RNN (ResNet18), as well as an ensemble of convolutional and recurrent networks Stacked CNN-RNN. The results show that neural networks showed much higher accuracy in recognizing and classifying emotions than the machine learning algorithms used. Of the three neural network models presented, the CNN + BLSTM ensemble showed higher accuracy.


Information ◽  
2019 ◽  
Vol 10 (3) ◽  
pp. 98 ◽  
Author(s):  
Tariq Ahmad ◽  
Allan Ramsay ◽  
Hanady Ahmed

Assigning sentiment labels to documents is, at first sight, a standard multi-label classification task. Many approaches have been used for this task, but the current state-of-the-art solutions use deep neural networks (DNNs). As such, it seems likely that standard machine learning algorithms, such as these, will provide an effective approach. We describe an alternative approach, involving the use of probabilities to construct a weighted lexicon of sentiment terms, then modifying the lexicon and calculating optimal thresholds for each class. We show that this approach outperforms the use of DNNs and other standard algorithms. We believe that DNNs are not a universal panacea and that paying attention to the nature of the data that you are trying to learn from can be more important than trying out ever more powerful general purpose machine learning algorithms.


2020 ◽  
Author(s):  
Thomas R. Lane ◽  
Daniel H. Foil ◽  
Eni Minerali ◽  
Fabio Urbina ◽  
Kimberley M. Zorn ◽  
...  

<p>Machine learning methods are attracting considerable attention from the pharmaceutical industry for use in drug discovery and applications beyond. In recent studies we have applied multiple machine learning algorithms, modeling metrics and in some cases compared molecular descriptors to build models for individual targets or properties on a relatively small scale. Several research groups have used large numbers of datasets from public databases such as ChEMBL in order to evaluate machine learning methods of interest to them. The largest of these types of studies used on the order of 1400 datasets. We have now extracted well over 5000 datasets from CHEMBL for use with the ECFP6 fingerprint and comparison of our proprietary software Assay Central<sup>TM</sup> with random forest, k-Nearest Neighbors, support vector classification, naïve Bayesian, AdaBoosted decision trees, and deep neural networks (3 levels). Model performance <a>was</a> assessed using an array of five-fold cross-validation metrics including area-under-the-curve, F1 score, Cohen’s kappa and Matthews correlation coefficient. <a>Based on ranked normalized scores for the metrics or datasets all methods appeared comparable while the distance from the top indicated Assay Central<sup>TM</sup> and support vector classification were comparable. </a>Unlike prior studies which have placed considerable emphasis on deep neural networks (deep learning), no advantage was seen in this case where minimal tuning was performed of any of the methods. If anything, Assay Central<sup>TM</sup> may have been at a slight advantage as the activity cutoff for each of the over 5000 datasets representing over 570,000 unique compounds was based on Assay Central<sup>TM</sup>performance, but support vector classification seems to be a strong competitor. We also apply Assay Central<sup>TM</sup> to prospective predictions for PXR and hERG to further validate these models. This work currently appears to be the largest comparison of machine learning algorithms to date. Future studies will likely evaluate additional databases, descriptors and algorithms, as well as further refining methods for evaluating and comparing models. </p><p><b> </b></p>


2021 ◽  
pp. 1-59
Author(s):  
Frederik Hartmann

Abstract Discussion of the exact phonetic value of the so-called ‘laryngeals’ in Proto-Indo-European has been ongoing ever since their discovery, and no uniform consensus has yet been reached. This paper aims at introducing a new method to determine the quality of the laryngeals that differs substantially from traditional techniques previously applied to this problem, by making use of deep neural networks as part of the larger field of machine learning algorithms. Phonetic environment data serves as the basis for training the networks, enabling the algorithm to determine sound features solely by their immediate phonetic neighbors. It proves possible to assess the phonetic features of the laryngeals computationally and to propose a quantitatively founded interpretation.


2020 ◽  
Author(s):  
Thomas R. Lane ◽  
Daniel H. Foil ◽  
Eni Minerali ◽  
Fabio Urbina ◽  
Kimberley M. Zorn ◽  
...  

<p>Machine learning methods are attracting considerable attention from the pharmaceutical industry for use in drug discovery and applications beyond. In recent studies we have applied multiple machine learning algorithms, modeling metrics and in some cases compared molecular descriptors to build models for individual targets or properties on a relatively small scale. Several research groups have used large numbers of datasets from public databases such as ChEMBL in order to evaluate machine learning methods of interest to them. The largest of these types of studies used on the order of 1400 datasets. We have now extracted well over 5000 datasets from CHEMBL for use with the ECFP6 fingerprint and comparison of our proprietary software Assay Central<sup>TM</sup> with random forest, k-Nearest Neighbors, support vector classification, naïve Bayesian, AdaBoosted decision trees, and deep neural networks (3 levels). Model performance <a>was</a> assessed using an array of five-fold cross-validation metrics including area-under-the-curve, F1 score, Cohen’s kappa and Matthews correlation coefficient. <a>Based on ranked normalized scores for the metrics or datasets all methods appeared comparable while the distance from the top indicated Assay Central<sup>TM</sup> and support vector classification were comparable. </a>Unlike prior studies which have placed considerable emphasis on deep neural networks (deep learning), no advantage was seen in this case where minimal tuning was performed of any of the methods. If anything, Assay Central<sup>TM</sup> may have been at a slight advantage as the activity cutoff for each of the over 5000 datasets representing over 570,000 unique compounds was based on Assay Central<sup>TM</sup>performance, but support vector classification seems to be a strong competitor. We also apply Assay Central<sup>TM</sup> to prospective predictions for PXR and hERG to further validate these models. This work currently appears to be the largest comparison of machine learning algorithms to date. Future studies will likely evaluate additional databases, descriptors and algorithms, as well as further refining methods for evaluating and comparing models. </p><p><b> </b></p>


Author(s):  
Eduard Barbu ◽  
Kadri Muischnek ◽  
Linda Freienthal

The first study for Estonian pronominal coreference resolution using machine learning is presented. Appropriate machine learning algorithms and techniques for balancing the data are tested on a human-annotated corpus. The results are encouraging, showing an F-score comparable with the results obtained for English before the advent of deep neural networks.


Author(s):  
S. R. Mani Sekhar ◽  
G. M. Siddesh

Machine learning is one of the important areas in the field of computer science. It helps to provide an optimized solution for the real-world problems by using past knowledge or previous experience data. There are different types of machine learning algorithms present in computer science. This chapter provides the overview of some selected machine learning algorithms such as linear regression, linear discriminant analysis, support vector machine, naive Bayes classifier, neural networks, and decision trees. Each of these methods is illustrated in detail with an example and R code, which in turn assists the reader to generate their own solutions for the given problems.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sho Nakagome ◽  
Trieu Phat Luu ◽  
Yongtian He ◽  
Akshay Sujatha Ravindran ◽  
Jose L. Contreras-Vidal

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