Human Drug-Pathway Association Prediction Based on Network Consistency Projection

Author(s):  
Ali Ghulam ◽  
Xiujuan Lei ◽  
Yuchen Zhang ◽  
Zhenqiang Wu
Keyword(s):  
2019 ◽  
Vol 33 (23) ◽  
pp. 1950264
Author(s):  
Meifeng Dai ◽  
Tingting Ju ◽  
Yongbo Hou ◽  
Jianwei Chang ◽  
Yu Sun ◽  
...  

Recently, the study of many kinds of weighted networks has received the attention of researchers in the scientific community. In this paper, first, a class of weighted star-composed networks with a weight factor is introduced. We focus on the network consistency in linear dynamical system for a class of weighted star-composed networks. The network consistency can be characterized as network coherence by using the sum of reciprocals of all nonzero Laplacian eigenvalues, which can be obtained by using the relationship of Laplacian eigenvalues at two successive generations. Remarkably, the Laplacian matrix of the class of weighted star-composed networks can be represented by the Kronecker product, then the properties of the Kronecker product can be used to obtain conveniently the corresponding characteristic roots. In the process of finding the sum of reciprocals of all nonzero Laplacian eigenvalues, the key step is to obtain the relationship of Laplacian eigenvalues at two successive generations. Finally, we obtain the main results of the first- and second-order network coherences. The obtained results show that if the weight factor is 1 then the obtained results in this paper coincide with the previous results on binary networks, otherwise the scalings of the first-order network coherence are related to the node number of attaching copy graph, the weight factor and generation number. Surprisingly, the scalings of the first-order network coherence are independent of the node number of initial graph. Consequently, it will open up new perspectives for future research.


RSC Advances ◽  
2019 ◽  
Vol 9 (57) ◽  
pp. 33222-33228 ◽  
Author(s):  
Guanghui Li ◽  
Yingjie Yue ◽  
Cheng Liang ◽  
Qiu Xiao ◽  
Pingjian Ding ◽  
...  

A network consistency projection model for predicting novel circRNA–disease interactions.


2018 ◽  
pp. 663-672
Author(s):  
Gordana Vojkovic ◽  
Zora Zivanovic ◽  
Ivana Magdalenic

The significance of the regional disproportions at the territory of Serbia, when it comes to demographic resources, imposes in front of the social community a task for public policy measures to be more efficient and more precisely addressed towards the local communities where the limit of their possible acting has not been perturbated yet. Thus, defining of coherent public policies requires good research of the demographic processes and problems on all levels and defining developmental solutions in accordance with them. Dimensioning of demographic potentials is one of the challenges and priorities of spatial planning as well, as a controlling instrument that has been gaining significance in modern conditions. Foreign experience in this field, i.e. the system of spatial planning in European countries, with the special attention paid to the ways of solving problems connected to demographic processes and appearances, is undoubtedly instructive for the domestic practice and the establishment of public policies on state and lower regional levels. Given the fact that the inequality in development is caused, above all, by the expressive metroplization and polarization of the Serbian territory, in modern conditions it is considered that the application of the polycentric development model could help avoiding further excessive economic and demographic concentration. It includes economic competitiveness and social equality (sustainable development) as pre-requisites for the diminishing of local disparities to the acceptable minimum. In that sense, it is considered that a group of middle sized towns represents a pivot in establishing homogeneous national urban system which would lead to the increase in the degree of settlement network consistency. It is necessary that the endeavour to decentralize Serbia be elaborated with concrete measures and instruments that would route further state development, meaning affirmation of the middle sized towns.


1970 ◽  
Vol 30 (2) ◽  
pp. 120-144
Author(s):  
Richard Peters ◽  
Peggy Golden

As academic and practitioners continue to demand greater stakeholder acknowledgementand engagement, firms must seek ways to move beyond dyadic interactionsand treat internal and external stakeholders as components of a holisticnetwork. This paper introduces two new constructs, Network Diversity and NetworkConsistency, proposing that both the variety of stakeholder partners (Network Diversity)as well as the uniformity of social performance across multiple stakeholderconstituencies (Network Consistency), will influence Corporate Reputation (CR)and ultimately, firm financial performance. Using a sample of 158 firms, across afive year time span,we find that while Network Diversity has no significant relationshipto CR, Network Consistency is in fact related to Corporate Reputation. Further,high levels of Network Diversity may actually detract from, rather than enhancefinancial performance, via increased cost and relationship management complexity.


2021 ◽  
Author(s):  
Ciro De Luca ◽  
Assunta Virtuoso ◽  
Nicola Maggio ◽  
Michele Cerasuolo ◽  
Anna Maria Colangelo ◽  
...  

Abstract The neuroglial network characterizes synaptic transmission and accounts for both cellular elements (neurons and glia) and neural extracellular matrix (nECM) roles. Glial cells, neuron, and nECMnetwork is strongly interconnected, in physiological and pathological conditions as shownin several neurodegenerative diseases. Purinergic activation and matrix metalloproteinases (MMPs) remodeling of the spinal cord is pivotal in maladaptive plastic changes following peripheral nerve injury (PNI). To understand how purinergic and MMPs inhibition may modulate and potentially reverse the neuroglial network failure, we used the spared nerve injury (SNI) model of the sciatic nerve. Molecular and morphological analysis of astrocytic and microglial activation, purinergic and neurotrophic receptors, Histone Deacetylase (HDAC)1, HDAC2 were analyzed to define the pathways in response to the purinergic and MMPs inhibition. The data suggest complex protein interconnections, which are not passively influenced by epigenetics but actively contribute to modify the transcriptomics machinery. The present study contributes to unveiling the spinal network consistency and ultimately encourages new paths for targeted treatments in neurological diseases with benefits of neuroprotection, plasticity, and functional recovery.


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