scholarly journals Spatio-Temporal Economic Properties of Multi-Product Supply Chains

2022 ◽  
pp. 107666
Author(s):  
Philip A. Tominac ◽  
Weiqi Zhang ◽  
Victor M. Zavala
Keyword(s):  
Supply Chains ◽  
Spatio Temporal

scholarly journals Modular sovereignty and infrastructural power: The elusive materiality of international statebuilding

2021 ◽  
pp. 096701062110519
Author(s):  
Jutta Bakonyi
Keyword(s):  
Supply Chains ◽  
Modular Forms ◽  
Sovereign Power ◽  
Mobile Form ◽  
Sovereign State ◽  
International Airport ◽  
Frontier Zone ◽  
Spatio Temporal ◽  
International Statebuilding ◽  
Infrastructural Power

This article uses the example of the Mogadishu International Airport zone and takes a spatio-temporal lens to explore how (sovereign) power unfolds in international interventions that aim at building a sovereign state. I show that the Mogadishu International Airport zone emerges as an elastic frontier zone that contradicts the sovereign imaginary intervenors aim to project and undermines many of the taken-for-granted boundaries that states tend to produce. The Mogadishu International Airport and similar zones emphasize the centrality of logistics and circulation in interventions, but also point towards their temporal and liminal character. Modularity became the material answer to the demand to secure circulation while adapting to the rapid rhythm and short timeframes of statebuilding. Modular designs enable the constant adaptation of the intervention terrain, allow intervenors to deny their power and imprint and facilitate the commercialization of supply chains and intervention materials. Sovereign power that operates through such zones becomes modular itself. It is exercised as an adaptable, in parts exchangeable, and highly mobile form of power that operates through crises and emergencies. The spaces and materials created by modular forms of sovereign power remain elusive, but nonetheless stratify experiences of power and security.

E3 ubiquitin ligases

2005 ◽  
Vol 41 ◽  
pp. 15-30 ◽  
Author(s):  
Helen C. Ardley ◽  
Philip A. Robinson
Keyword(s):  
Protein Complexes ◽  
Loss Of Function ◽  
Direct Role ◽  
Cellular Processes ◽  
Substrate Protein ◽  
Protein Ubiquitination ◽  
C Terminus ◽  
Full Complement ◽  
Spatio Temporal ◽  
Eukaryotic Organisms

The selectivity of the ubiquitin–26 S proteasome system (UPS) for a particular substrate protein relies on the interaction between a ubiquitin-conjugating enzyme (E2, of which a cell contains relatively few) and a ubiquitin–protein ligase (E3, of which there are possibly hundreds). Post-translational modifications of the protein substrate, such as phosphorylation or hydroxylation, are often required prior to its selection. In this way, the precise spatio-temporal targeting and degradation of a given substrate can be achieved. The E3s are a large, diverse group of proteins, characterized by one of several defining motifs. These include a HECT (homologous to E6-associated protein C-terminus), RING (really interesting new gene) or U-box (a modified RING motif without the full complement of Zn2+-binding ligands) domain. Whereas HECT E3s have a direct role in catalysis during ubiquitination, RING and U-box E3s facilitate protein ubiquitination. These latter two E3 types act as adaptor-like molecules. They bring an E2 and a substrate into sufficiently close proximity to promote the substrate's ubiquitination. Although many RING-type E3s, such as MDM2 (murine double minute clone 2 oncoprotein) and c-Cbl, can apparently act alone, others are found as components of much larger multi-protein complexes, such as the anaphase-promoting complex. Taken together, these multifaceted properties and interactions enable E3s to provide a powerful, and specific, mechanism for protein clearance within all cells of eukaryotic organisms. The importance of E3s is highlighted by the number of normal cellular processes they regulate, and the number of diseases associated with their loss of function or inappropriate targeting.

Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors

2019 ◽  
Vol 47 (6) ◽  
pp. 1733-1747 ◽  
Author(s):  
Christina Klausen ◽  
Fabian Kaiser ◽  
Birthe Stüven ◽  
Jan N. Hansen ◽  
Dagmar Wachten
Keyword(s):  
Cyclic Amp ◽  
Adenosine Monophosphate ◽  
Adenylyl Cyclases ◽  
Temporal Precision ◽  
Fluorescent Biosensors ◽  
Subcellular Domains ◽  
Spatio Temporal ◽  
Hydrolysis Of ◽  
Shed Light ◽  
Cyclic Amp Signaling

The second messenger 3′,5′-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil specific functions. To define the function of cAMP within these microdomains, signaling needs to be analyzed with spatio-temporal precision. To this end, optogenetic approaches and genetically encoded fluorescent biosensors are particularly well suited. Synthesis and hydrolysis of cAMP can be directly manipulated by photoactivated adenylyl cyclases (PACs) and light-regulated phosphodiesterases (PDEs), respectively. In addition, many biosensors have been designed to spatially and temporarily resolve cAMP dynamics in the cell. This review provides an overview about optogenetic tools and biosensors to shed light on the subcellular organization of cAMP signaling.

An online cost allocation model for horizontal supply chains

2021 ◽  
Vol 122 ◽  
pp. 102888
Author(s):  
Han Zou ◽  
Maged M. Dessouky ◽  
Shichun Hu
Keyword(s):  
Supply Chains ◽  
Cost Allocation ◽  
Allocation Model

Spatio-temporal changes on crime patterns in Saudi Arabia from 2003-2012

2014 ◽  
Author(s):  
Mofza Algahtany ◽  
Lalit Kumar ◽  
Hassan M. Khormi
Keyword(s):  
Saudi Arabia ◽  
Temporal Changes ◽  
Crime Patterns ◽  
Spatio Temporal
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