scholarly journals Polarity-specific transcranial direct current stimulation effects on object-selective neural responses in the inferior parietal lobe

Cortex ◽  
2017 ◽  
Vol 94 ◽  
pp. 176-181 ◽  
Author(s):  
Jorge Almeida ◽  
Ana R. Martins ◽  
Fredrik Bergström ◽  
Lénia Amaral ◽  
Andreia Freixo ◽  
...  
2016 ◽  
Vol 28 (8) ◽  
pp. 1063-1089 ◽  
Author(s):  
Lauren E. Mancuso ◽  
Irena P. Ilieva ◽  
Roy H. Hamilton ◽  
Martha J. Farah

Transcranial direct current stimulation (tDCS) has been reported to improve working memory (WM) performance in healthy individuals, suggesting its value as a means of cognitive enhancement. However, recent meta-analyses concluded that tDCS has little or no effect on WM in healthy participants. In this article, we review reasons why these meta-analyses may have underestimated the effect of tDCS on WM and report a more comprehensive and arguably more sensitive meta-analysis. Consistent with our interest in enhancement, we focused on anodal stimulation. Thirty-one articles matched inclusion criteria and were included in four primary meta-analyses assessing the WM effects of anodal stimulation over the left and right dorsolateral pFC (DLPFC) and right parietal lobe as well as left DLPFC stimulation coupled with WM training. These analyses revealed a small but significant effect of left DLPFC stimulation coupled with WM training. Left DLPFC stimulation alone also enhanced WM performance, but the effect was reduced to nonsignificance after correction for publication bias. No other effects were significant, including a variety of tested moderators. Additional meta-analyses were undertaken with study selection criteria based on previous meta-analyses, to reassess the findings from these studies using the analytic methods of this study. These analyses revealed a mix of significant and nonsignificant small effects. We conclude that the primary WM enhancement potential of tDCS probably lies in its use during training.


Symmetry ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2077
Author(s):  
Vanessa Costa ◽  
Giuseppe Giglia ◽  
Simona Talamanca ◽  
Chiara Finocchiaro ◽  
Giuseppe Cosentino ◽  
...  

Evidence derived from functional imaging and brain-lesion studies has shown a strong left lateralization for language, and a complementary right hemisphere dominance for visuospatial abilities. Nevertheless, the symmetrical functional division of the two hemispheres gives no reason for the complexity of the cognitive operations involved in carrying out a linguistic task. In fact, a growing number of neuroimaging and neurostimulation studies suggest a possible right hemisphere involvement in language processing. The objective of this work was to verify the contribution of the left and right parietal areas in a phonological task. We applied anodal transcranial direct current stimulation (tDCS) to the right or left inferior parietal lobe, during a syllabic reordering task. After having learnt a combination of images of real objects and trisyllabic pseudowords with a simple consonant–vowel (CV) syllabic structure (e.g., tu-ru-cu), participants were shown the same images paired to two different pseudowords: one correct but with transposed syllables, and one alternative, never before seen. The participant’s task was to orally produce the chosen pseudoword, after having rearranged the order of its syllables. Two types of error were considered: transposition (correct pseudoword but incorrectly reordered) and identity (incorrect pseudoword). The results showed that right anodal stimulation significantly reduced the number of transposition errors, whereas left anodal stimulation significantly reduced the number of identity errors. These results suggested that both left and right inferior parietal areas were differentially involved in a syllabic reordering task, and, crucially, they demonstrated that visuospatial processes served by the right inferior parietal area could be competent for establishing the correct syllabic order within a word.


2021 ◽  
Author(s):  
Sung Ho Jang ◽  
Chul Hoon Chang ◽  
Sung Jun Lee

Abstract A 52-year-old female patient underwent craniectomy and hematoma removal for a spontaneous intracerebral hemorrhage in the left parietal lobe, as well as intraventricular and subarachnoid hemorrhages (Fig. 1-A). Brain magnetic resonance images obtained three months after onset showed leukomalactic lesions in the left parieto-occipital lobes (Fig. 1-A). Initially, the patient was in a vegetative state with a Coma Recovery Scale-revised score of 11 (auditory function: 2, visual function: 4, motor function: 2, verbal function: 1, communication: 0, and arousal: 2) (1). Subsequently, she underwent comprehensive rehabilitation, which included neurotropic drug treatments (armodafinil, pramipexole, amantadine, levodopa, and baclofen) and physical and occupational therapies (including tilt table standing). In addition, transcranial direct current stimulation was administered by using a neuroConn DC-stimulator. The anode was placed on the left parietal lobe (centered on the supraparietal lobule) and the cathode was placed on the opposite supraorbital region. The transcranial direct current stimulation intensity was 2 mA and the duration was 20 minutes/session with one session/day and seven sessions/week. Repetitive transcranial magnetic stimulation using a MagPro stimulator was applied to mid-portion of the right intraparietal sulcus at a frequency of 10 Hz with an 80% motor threshold intensity and 160 pulses for 8 minutes/session with one session/day and seven sessions/week. After one month of rehabilitation, the patient had recovered to a nearly normal conscious state with a Coma Recovery Scale-revised score of 21 (auditory function: 4, visual function: 5, motor function: 5, verbal function: 2, communication: 2, arousal: 3) [1]. The patient’s sister provided signed, informed consent, and the study protocol was approved by our institutional review board.


2009 ◽  
Vol 40 (01) ◽  
Author(s):  
F Buttkus ◽  
V Baur ◽  
HC Jabusch ◽  
M Weidenmüller ◽  
S Schneider ◽  
...  

2014 ◽  
Vol 33 (05) ◽  
pp. 382-386
Author(s):  
A. Hasan ◽  
S. Dehning ◽  
D. Keeser ◽  
I. Hummel ◽  
P. Falkai ◽  
...  

Zusammenfassung Gegenstand und Ziel: Die transkranielle Gleichstromstimulation (transcranial direct current stimulation, tDCS) wird als neues nicht invasives Hirnstimulationsverfahren für die Behandlung neurologischer und psychiatrischer Erkrankungen untersucht. Mittlerweile gibt es Fallberichte und eine randomisierte, kontrollierte Pilotstudie zur Behandlung akustischer Halluzinationen sowie der Negativsymptomatik bei Schizophrenie. Fallbericht: Im vorliegenden Fallbericht wurde ein Patient mit therapieresistenter Symptomatik bei paranoider Schizophrenie drei Wochen lang mit anodaler tDCS über dem linken dorsolateralen und kathodaler tDCS über dem rechten dorsolateralen Kortex behandelt. Ergebnisse: Es zeigte sich eine Verbesserung von Affektivität und Kognition, die Positivsymptome blieben jedoch nahezu unverändert. Klinische Relevanz: Die bifrontale tDCS stellt eine nebenwirkungsarme neue Behandlungsform dar und sollte in der Anwendung bei Erkrankungen aus dem schizophrenen Formenkreis weiter untersucht werden.


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