Executive function in children with Tourette syndrome and attention-deficit/hyperactivity disorder: Cross-disorder or unique impairments?

AbstractTourette Syndrome (TS) in children is associated with various neurobehavioral disorders including attention deficit hyperactivity disorder (ADHD). Children with TS and ADHD show some difficulties with neuropsychological tasks, but we do not know if children with TS alone have neuropsychological deficits. To assess specific cognitive differences among children with TS and/or ADHD, we administered a battery of neuropsychological tests, including 10 tasks related to executive function (EF), to 10 children with TS-only, 48 with ADHD-only, and 32 with TS+ADHD. Children in all groups could not efficiently produce output on a timed continuous performance task [Test of Variables of Attention (TOVA) mean reaction time and reaction time variability]. Children with TS-only appeared to have fewer EF impairments and significantly higher perceptual organization scores than children with TS+ADHD or ADHD-only. These findings suggest that deficiencies in choice reaction time and consistency of timed responses are common to all three groups, but children with TS-only have relatively less EF impairment than children with TS+ADHD or ADHD-only. (JINS, 1995, 1, 511–516.)

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The Influence of "Hot" Executive Function on the Verbal Working Memory of Attention Deficit Hyperactivity Disorder (ADHD) and Reading Disability (RD) Children

Acta Psychologica Sinica ◽

10.3724/sp.j.1041.2010.00415 ◽

2010 ◽

Vol 42 (3) ◽

pp. 415-422

Author(s):

Wei ZHANG ◽

Xiang-Ping LIU ◽

Hong-Yan SONG

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Working Memory ◽

Executive Function ◽

Reading Disability ◽

Attention Deficit ◽

Verbal Working Memory ◽

Hyperactivity Disorder

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Books and More: Tictionary: A Reference Guide to the World of Tourette Syndrome, Asperger Syndrome, Attention Deficit Hyperactivity Disorder and Obsessive Compulsive Disorder for Parents and Professionals

Intervention in School and Clinic ◽

10.1177/10534512030390020801 ◽

2003 ◽

Vol 39 (2) ◽

pp. 127-127

Author(s):

Chris K. Ormsbee ◽

Spencer Nolan

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Asperger Syndrome ◽

Obsessive Compulsive Disorder ◽

Tourette Syndrome ◽

Attention Deficit ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Reference Guide ◽

Hyperactivity Disorder ◽

The World

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Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder

Cortex ◽

10.1016/j.cortex.2021.12.006 ◽

2021 ◽

Author(s):

Simon Morand-Beaulieu ◽

Stephanie D. Smith ◽

Karim Ibrahim ◽

Jia Wu ◽

James F. Leckman ◽

...

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Tourette Syndrome ◽

Inhibitory Control ◽

Attention Deficit ◽

Hyperactivity Disorder

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Neuropsychological Functioning in Children With Tourette Syndrome With and Without Attention-Deficit/Hyperactivity Disorder

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1097/00004583-201011000-00009 ◽

2010 ◽

Vol 49 (11) ◽

pp. 1155-1164e1 ◽

Cited By ~ 2

Author(s):

Denis G. Sukhodolsky ◽

Angeli Landeros-Weisenberger ◽

Lawrence Scahill ◽

James F. Leckman ◽

Robert T. Schultz

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Tourette Syndrome ◽

Attention Deficit ◽

Neuropsychological Functioning ◽

Hyperactivity Disorder

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Development of Tics in a Thirteen-Year-Old Male Following Atomoxetine Use

CNS Spectrums ◽

10.1017/s1092852900016412 ◽

2008 ◽

Vol 13 (4) ◽

pp. 301-303 ◽

Cited By ~ 13

Author(s):

Jessica Sears ◽

Nitin C. Patel

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Single Dose ◽

Tourette Syndrome ◽

Attention Deficit ◽

Interventional Therapy ◽

Prior History ◽

Unique Case ◽

Hyperactivity Disorder ◽

History Of ◽

Pharmacologic Therapies

ABSTRACTTics and Tourette syndrome are common comorbidities of patients diagnosed with attention-deficit/hyperactivity disorder (ADHD). One of the mainstay pharmacologic therapies for ADHD has been stimulants. However, this class of drugs has been associated with tic exacerbations, thus limiting their utility in this patients subgroup. Atomoxetine has been explored as an alternative treatment as one of the few non-stimulants available to treat ADHD. Early data identifies atomoxetine's influence on Tourette symptomatology to be not merely equivocal but potentially suppressive in the manifestation of tics. There are, however, case studies describing patients experiencing recurrences of tics following treatment with atomoxetine. We present a unique case of a patient, without any prior history of a movement disorder, who developed tics following a single dose of atomoxetine that did not improve until interventional therapy was initiated.

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