The clinical value of hepatic extracellular volume fraction using routine multiphasic contrast-enhanced liver CT for staging liver fibrosis

2017 ◽  
Vol 72 (3) ◽  
pp. 242-246 ◽  
Author(s):  
S.L. Guo ◽  
L.N. Su ◽  
Y.N. Zhai ◽  
W.M. Chirume ◽  
J.Q. Lei ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Volume Fraction ◽  
Extracellular Volume ◽  
Extracellular Volume Fraction ◽  
Clinical Value ◽  
Liver Ct ◽  
Contrast Enhanced

Evaluation of liver fibrosis using hepatic extracellular volume fraction by contrast-enhanced computed tomography before and after direct-acting antiviral therapy in patients with chronic hepatitis C infection: comparison with serological liver fibrosis markers

2021 ◽  
Author(s):  
Akihiko Kanki ◽  
Kiyoka Maeba ◽  
Hidemitsu Sotozono ◽  
Kazuya Yasokawa ◽  
Atsushi Higaki ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Liver Fibrosis ◽  
Antiviral Therapy ◽  
Volume Fraction ◽  
Extracellular Volume ◽  
Control Group ◽  
Direct Acting Antiviral ◽  
Contrast Enhanced ◽  
Before And After ◽  
Direct Acting

Objective: To evaluate time-dependent changes in hepatic extracellular volume (ECV) fraction using contrast-enhanced CT (CECT) and serological liver fibrosis markers, the fibrosis-4 (FIB-4) index and aspartate aminotransferase to platelet ratio index (APRI), before and after direct-acting antiviral therapy (DAA) for hepatitis C virus (HCV) infection. Methods: 41 HCV-infected patients who achieved sustained virological response (SVR) after DAA (SVR group) and 10 control patients (untreated or unresponsive to treatment) who underwent CECT and serum biochemical tests before or after the first examination/DAA (T1) and at intervals thereafter (T2:<6 months after T1, T3: at 6–12 months, T4: at 12–24 months, and T5:>24 months) were evaluated. Results: In the control group, ECV fractions remained relatively unchanged through the study, and significant differences in FIB-4 index comparisons and APRI comparisons were only seen between the T2 and T4 values (p = 0.046 and p = 0.028, respectively). In the SVR group, ECV fractions were significantly different between T1 and T4 and T1 and T5 (p = 0.046 and 0.022, respectively), and both FIB-4 index and APRI were significantly different between T1 and all other time points (p = 0.017 to p < 0.001 and p = 0.001 to p < 0.001, respectively). Conclusion: After DAA, ECV fraction decreased slowly, suggesting an improvement in hepatic fibrosis, while serological liver fibrosis markers decreased immediately, probably due to improvement in hepatic inflammation. Advances in knowledge: ECV fraction has the potential to be a non-invasive biomarker for the assessment of liver fibrosis after direct-acting antiviral therapy.

scholarly journals Equilibrium CT Texture Analysis for the Evaluation of Hepatic Fibrosis: Preliminary Evaluation against Histopathology and Extracellular Volume Fraction

2020 ◽  
Vol 10 (2) ◽  
pp. 46
Author(s):  
Jason Yeung ◽  
Balaji Ganeshan ◽  
Raymond Endozo ◽  
Andrew Hall ◽  
Simon Wan ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Texture Analysis ◽  
Volume Fraction ◽  
Extracellular Volume ◽  
Equilibrium Phase ◽  
Extracellular Volume Fraction ◽  
Diffuse Fibrosis ◽  
Preliminary Evaluation ◽  
Ct Texture Analysis

Background: Evaluate equilibrium contrast-enhanced CT (EQ-CT) texture analysis (EQ-CTTA) against histologically-quantified fibrosis, serum-based enhanced liver fibrosis panel (ELF) and imaging-based extracellular volume fraction (ECV) in chronic hepatitis. Methods: This study was a re-analysis of image data from a previous prospective study. Pre- and equilibrium-phase post-IV contrast CT datasets were collected from patients with chronic hepatitis with contemporaneous liver biopsy and serum ELF measurement between April 2011 and July 2013. Biopsy samples were analysed to derive collagen proportionate area (CPA). EQ-CTTA was performed with a filtration histogram technique using texture analysis software, with texture quantification using statistical and histogram-based metrics (mean, skewness, standard deviation, entropy, etc.). Association between pre-contrast and EQ-CTTA against CPA, ECV and ELF was evaluated using Spearman’s rank correlation coefficient (rs). Results: Complete datasets collected in 29 patients (16 male; 13 female), mean age (range): 49 (22–66 years). Liver ECV, CPA and ELF had a median (interquartile range) of 0.26 (0.24–0.29); 5.0 (3.0–13.7) and 9.71 (8.39–10.92). Difference in segment VII hepatic CTTA (medium texture scale) between EQ-CT and pre-contrast images was significantly and positively associated with ELF score (mean: rs = 0.69, p < 0.001; skewness: rs = 0.57, p = 0.007). Significant negative associations were observed between pre-contrast and EQ-CT whole hepatic CTTA (coarse texture scale) with CPA (pre-contrast, SD: rs = −0.66, p < 0.001) and ECV (EQ-CT, entropy: rs = −0.58, p = 0.006). Conclusions: Hepatic EQ-CTTA demonstrates significant association with validated markers of liver fibrosis, suggesting a role in non-invasive quantification of severity in diffuse fibrosis.

Hepatic fibrosis grading with extracellular volume fraction from iodine mapping in spectral liver CT

2021 ◽  
Vol 137 ◽  
pp. 109604
Author(s):  
Jeong Hee Yoon ◽  
Jeong Min Lee ◽  
Jae Hyun Kim ◽  
Kyoung-Bun Lee ◽  
Haeryoung Kim ◽  
...  
Keyword(s):  
Hepatic Fibrosis ◽  
Volume Fraction ◽  
Extracellular Volume ◽  
Extracellular Volume Fraction ◽  
Liver Ct

Quantitative liver MRI including extracellular volume fraction for non-invasive quantification of liver fibrosis: a prospective proof-of-concept study

Gut ◽  
2017 ◽  
Vol 67 (3) ◽  
pp. 593-594 ◽  
Author(s):  
Julian A Luetkens ◽  
Sabine Klein ◽  
Frank Traeber ◽  
Frederic C Schmeel ◽  
Alois M Sprinkart ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Volume Fraction ◽  
Extracellular Volume ◽  
Extracellular Volume Fraction ◽  
Proof Of Concept ◽  
Liver Mri ◽  
Concept Study ◽  
Non Invasive

scholarly journals Quantification of Liver Fibrosis at T1 and T2 Mapping with Extracellular Volume Fraction MRI: Preclinical Results

Radiology ◽  
2018 ◽  
Vol 288 (3) ◽  
pp. 748-754 ◽  
Author(s):  
Julian A. Luetkens ◽  
Sabine Klein ◽  
Frank Träber ◽  
Frederic C. Schmeel ◽  
Alois M. Sprinkart ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Volume Fraction ◽  
T2 Mapping ◽  
Extracellular Volume ◽  
Extracellular Volume Fraction ◽  
T1 And T2
Sign in / Sign up

Export Citation Format

Share Document