scholarly journals Total Antioxidant Capacity in beta-thalassemia: A systematic review and meta-analysis of case-control studies

2017 ◽  
Vol 110 ◽  
pp. 35-42 ◽  
Author(s):  
Husseen Manafikhi ◽  
Gregor Drummen ◽  
Maura Palmery ◽  
Ilaria Peluso
Keyword(s):  
Systematic Review ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Meta Analysis ◽  
Case Control ◽  
Beta Thalassemia ◽  
Case Control Studies ◽  
Total Antioxidant

Effects of Astaxanthin Supplementation on Oxidative Stress

2020 ◽  
Vol 90 (1-2) ◽  
pp. 179-194 ◽  
Author(s):  
Di Wu ◽  
Hao Xu ◽  
Jinyao Chen ◽  
Lishi Zhang
Keyword(s):  
Systematic Review ◽  
Superoxide Dismutase ◽  
Antioxidant Capacity ◽  
Subgroup Analysis ◽  
Total Antioxidant Capacity ◽  
Meta Analysis ◽  
Antioxidant Effect ◽  
High Dose ◽  
Standard Mean Difference ◽  
Total Antioxidant

Abstract. A systematic review and meta-analysis was conducted in six databases from 1948 to 2015 to assess the antioxidant activity of astaxanthin in humans. Nine randomized controlled trials were included in the systematic review. Results of meta-analysis revealed a borderline significant antioxidant effect of astaxanthin between the intervention and control groups, with a malondialdehyde-lowering effect for lipid peroxidation ( p = 0.050). However, the data included here are insufficient. When compared with the baseline in intervention groups, the meta-analysis suggested that astaxanthin supplements significantly decreased plasma malondialdehyde {Standard mean difference (SMD) −1.32 μmol/L [95% CI −1.92, −0.72]; p < 0.0001} and isoprostane (SMD −3.10 ng/mL [95% CI −4.69, −1.51]; p < 0.0001). However, they increased superoxide dismutase (SMD 1.57 U/mL [95% CI 0.57, 2.56]; p = 0.002) and total antioxidant capacity (SMD 0.77 mmol 95% CI [0.12, 1.43]; p = 0.018). For dosage subgroup analysis, high dose (≥20 mg/day) of astaxanthin showed significant antioxidant effect (on total antioxidant capacity, isoprostane, and superoxide dismutase, p < 0.05). However, low dose (<20 mg/day) showed no significant effect ( p > 0.05). Further duration subgroup analysis indicated that astaxanthin showed antioxidant effect after a 3-week intervention ( p < 0.001), whereas this effect was not observed after a 12-week or 3-month intervention (on isoprostane and superoxide dismutase, p > 0.05). This review suggested that the antioxidant effect of astaxanthin on humans is unclear.

Higher dietary total antioxidant capacity (TAC) reduces the risk of cardio-metabolic risk factors among adults: An updated systematic review and meta-analysis

2021 ◽  
pp. 1-15
Author(s):  
Mahdieh Abbasalizad Farhangi ◽  
Ali Mohammad-Rezaei
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Observational Studies ◽  
Meta Analysis ◽  
Dietary Antioxidants ◽  
Total Antioxidant ◽  
Dietary Total Antioxidant Capacity

Abstract. Background: Numerous studies have revealed the protective role of dietary antioxidants against hypertension and diabetes. In the current systematic review and meta-analysis, we evaluated the possible role of dietary total antioxidant capacity (TAC) against metabolic parameters in the adult population. Methods: A literature search of authentic electronic resources including PubMed, Scopus, Web of Sciences, and Cochrane had been performed to retrieve the qualified observational studies that reported the mean plus/minus the SD for the parameter in subjects of the highest versus lowest dietary TAC categories up to July 2020. Results: Totally, the number of included studies was 13 for fasting blood sugar (FBS), 12 for systolic blood pressure (SBP), and 12 for diastolic blood pressure (DBP), with the participants’ number of 26349. The results of the current study showed that being at highest category of TAC significantly reduces serum FBS (WMD: −2.381; CI: −3.445, −1.316; P<0.001), SBP (WMD: −1.080; CI: −1.458, −0.701; P<0.001) and DBP (WMD: −0.854; CI: −1.655, −0.052; P<0.001), while no significant difference in the serum insulin, HOMA-IR values, prevalence of type 2 diabetes (T2DM) (P=0.37) and hypertension (HTN) (P=0.09) was observed. Subgroup analysis revealed the geographical location, dietary assessment tool, sample size, and gender as possible sources of heterogeneity. Conclusion: Higher intake of dietary TAC was associated with reduced SBP, DBP, and FBS in the current observational studies of this meta-analysis. These findings further confirm the clinical importance of dietary antioxidants in the prevention of different metabolic disorders.

Does total antioxidant capacity affect the features of metabolic syndrome? A systematic review

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Sama Rasaee ◽  
Mohammad Alizadeh ◽  
Sorayya Kheirouri ◽  
Hadi Abdollahzad
Keyword(s):  
Systematic Review ◽  
Metabolic Syndrome ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Geographical Location ◽  
Assessment Tools ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Content Type ◽  
Total Antioxidant

Purpose There is some evidence that suggest a higher dietary total antioxidant capacity (DTAC) is associated with a lower risk of metabolic syndrome (MetS). Considering the conflicting results in this field, this paper aims to provide a comprehensive summary of studies on the association of DTAC and components of MetS. Design/methodology/approach A systematic review of articles indexed in PubMed, Scopus and Google Scholar, published from inception to September 2018, with defined keywords, was done. Duplicate or irrelevant reports were screened out and data were extracted through critical analysis. Finally, among the 353 articles, 19 articles met the inclusion criteria. Findings The included cohort studies revealed that higher DTAC was associated with reduced risk of MetS. Also, the association between DTAC and mortality risk of MetS was insignificant in these studies. The case–control studies showed high DTAC is inversely associated with MetS, its components and complications. The randomized controlled trials found that changes in DTAC were negatively correlated with oxidized low-density lipoprotein cholesterol and there was a positive association between DTAC and subjects’ weight and body mass index. Finally, results from the cross-sectional studies were inconsistence in this regard. Originality/value The assessed relationship between MetS or its components with DTAC is inconsistent in the included studies. Different sample size, dietary assessment tools, DTAC index values and geographical location may justify the observed inconsistencies. It seems that further studies are needed to reveal more confident and reliable findings.

Respiratory disturbances in fibromyalgia: a systematic review and meta-analysis of case control studies

2021 ◽  
Author(s):  
Araceli Ortiz-Rubio ◽  
Irene Torres-Sánchez ◽  
Irene Cabrera-Martos ◽  
Laura López-López ◽  
Janet Rodríguez-Torres ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Running and Knee Osteoarthritis: A Systematic Review and Meta-analysis

2016 ◽  
Vol 45 (6) ◽  
pp. 1447-1457 ◽  
Author(s):  
Kate A. Timmins ◽  
Richard D. Leech ◽  
Mark E. Batt ◽  
Kimberley L. Edwards
Keyword(s):  
Systematic Review ◽  
Full Text ◽  
Meta Analysis ◽  
Positive Association ◽  
Case Control ◽  
Case Control Studies ◽  
Eligibility Criteria ◽  
Knee Oa ◽  
Knee Joint Surgery ◽  
Newcastle Ottawa Scale

Background: Osteoarthritis (OA) is a chronic condition characterized by pain, impaired function, and reduced quality of life. A number of risk factors for knee OA have been identified, such as obesity, occupation, and injury. The association between knee OA and physical activity or particular sports such as running is less clear. Previous reviews, and the evidence that informs them, present contradictory or inconclusive findings. Purpose: This systematic review aimed to determine the association between running and the development of knee OA. Study Design: Systematic review and meta-analysis. Methods: Four electronic databases were searched, along with citations in eligible articles and reviews and the contents of recent journal issues. Two reviewers independently screened the titles and abstracts using prespecified eligibility criteria. Full-text articles were also independently assessed for eligibility. Eligible studies were those in which running or running-related sports (eg, triathlon or orienteering) were assessed as a risk factor for the onset or progression of knee OA in adults. Relevant outcomes included (1) diagnosis of knee OA, (2) radiographic markers of knee OA, (3) knee joint surgery for OA, (4) knee pain, and (5) knee-associated disability. Risk of bias was judged by use of the Newcastle-Ottawa scale. A random-effects meta-analysis was performed with case-control studies investigating arthroplasty. Results: After de-duplication, the search returned 1322 records. Of these, 153 full-text articles were assessed; 25 were eligible, describing 15 studies: 11 cohort (6 retrospective) and 4 case-control studies. Findings of studies with a diagnostic OA outcome were mixed. Some radiographic differences were observed in runners, but only at baseline within some subgroups. Meta-analysis suggested a protective effect of running against surgery due to OA: pooled odds ratio 0.46 (95% CI, 0.30-0.71). The I2 was 0% (95% CI, 0%-73%). Evidence relating to symptomatic outcomes was sparse and inconclusive. Conclusion: With this evidence, it is not possible to determine the role of running in knee OA. Moderate- to low-quality evidence suggests no association with OA diagnosis, a positive association with OA diagnosis, and a negative association with knee OA surgery. Conflicting results may reflect methodological heterogeneity. More evidence from well-designed, prospective studies is needed to clarify the contradictions.

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