ASSOCIATION BETWEEN STRESSFUL LIFE EVENTS AND AUTOIMMUNE DISEASES: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RETROSPECTIVE CASE-CONTROL STUDIES

2016 ◽  
Author(s):  
Brunetta Porcelli
Keyword(s):  
Systematic Review ◽  
Autoimmune Diseases ◽  
Life Events ◽  
Stressful Life Events ◽  
Meta Analysis ◽  
Case Control ◽  
Stressful Life ◽  
Case Control Studies ◽  
Retrospective Case

Association between stressful life events and autoimmune diseases: A systematic review and meta-analysis of retrospective case–control studies

2016 ◽  
Vol 15 (4) ◽  
pp. 325-334 ◽  
Author(s):  
Brunetta Porcelli ◽  
Andrea Pozza ◽  
Nicola Bizzaro ◽  
Andrea Fagiolini ◽  
Maria-Cristina Costantini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Autoimmune Diseases ◽  
Life Events ◽  
Stressful Life Events ◽  
Meta Analysis ◽  
Case Control ◽  
Stressful Life ◽  
Case Control Studies ◽  
Retrospective Case

A Systematic Review and Meta-Analysis of HLA-Class-II Associations in Patients with IgG4 Autoimmunity

2021 ◽  
Author(s):  
Anja Panhuber ◽  
Giovanni Lamorte ◽  
Veronica Bruno ◽  
Hakan Cetin ◽  
Wolfgang Bauer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Autoimmune Diseases ◽  
Genetic Risk ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Pemphigus Vulgaris ◽  
Case Control ◽  
Case Control Studies ◽  
Leukocyte Antigen ◽  
Susceptibility Factors

Abstract Autoimmune diseases caused by pathogenic IgG4 subclass autoantibodies (IgG4-AID) include diseases like MuSK myasthenia gravis, pemphigus vulgaris or thrombotic thrombocytopenic purpura. Their etiology is still unknown. Polymorphisms in the human leukocyte antigen (HLA) gene locus, particularly in HLA-DRB1, are known genetic susceptibility factors for autoimmune diseases. We hypothesized a similar role for HLA polymorphisms in IgG4-AID and conducted a systematic review and meta-analysis with case-control studies on IgG4-AID based on MOOSE/ HuGENet guidelines. Genotype (G) and allele (A) frequencies of HLA-DQB1*05 (G: OR 3.8; 95% CI 2.44-5.9; p < 0.00001; A: OR 2.54; 95% CI 1.82-3.55; p < 0.00001) and HLA-DRB1*14 (G: OR 4.31; 95% CI 2.82-6.59; p < 0.00001; A: OR 4.78; 95% CI 3.52-6.49; p < 0.00001) and the HLA-DRB1*14-DQB1*05 haplotype (OR 6.3; 95% CI 3.28-12.09; p < 0.00001 / OR 4.98; 95% CI 3.8-6.53; p < 0.00001) were increased while HLA-DRB1*13 (G: OR 0.48; 95% CI 0.34-0.68; p < 0.0001; A: OR 0.46; 95% CI 0.34-0.62; p < 0.00001) was decreased in IgG4-AID patients. In conclusion, the HLA-DQB1*05, HLA-DRB1*14 alleles and the HLA-DQB1*05-DRB1*14 haplotype could be genetic risk factors that predispose for the production of pathogenic IgG4 autoantibodies and the HLA-DRB1*13 allele may protect from IgG4 autoimmunity.

The relation between stressful life events and breast cancer: a systematic review and meta-analysis of cohort studies

2019 ◽  
Vol 176 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Narjes Bahri ◽  
Tahereh Fathi Najafi ◽  
Fatemeh Homaei Shandiz ◽  
Hamid Reza Tohidinik ◽  
Abdoljavad Khajavi
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Cohort Studies ◽  
Life Events ◽  
Stressful Life Events ◽  
Meta Analysis ◽  
Stressful Life

scholarly journals Are stressful life events prospectively associated with increased suicidal ideation and behaviour? A systematic review and meta-analysis

2020 ◽  
Vol 266 ◽  
pp. 731-742 ◽  
Author(s):  
Emma J. Howarth ◽  
Daryl B. O'Connor ◽  
Maria Panagioti ◽  
Alexander Hodkinson ◽  
Sarah Wilding ◽  
...  
Keyword(s):  
Systematic Review ◽  
Suicidal Ideation ◽  
Life Events ◽  
Stressful Life Events ◽  
Meta Analysis ◽  
Stressful Life

Association of Stress with Risk of Dementia and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 1-18
Author(s):  
Katherine H. Franks ◽  
Lisa Bransby ◽  
Michael M. Saling ◽  
Matthew P. Pase
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Life Events ◽  
Perceived Stress ◽  
Stressful Life Events ◽  
Meta Analysis ◽  
Stressful Life ◽  
Total N ◽  
Increased Risk

Background: Although many studies have investigated the association between stress and risk of dementia, findings are inconsistent due to the variation in the measures used to assess stress. Objective: We conducted a systematic review and meta-analysis to investigate the association between psychological stress (including neuroticism, stressful life events, and perceived stress) and the risk of incident dementia and mild cognitive impairment in adults. Methods: PsycINFO, Embase, and MEDLINE were searched to October 2020 for eligible observational, prospective studies. Of the 1,607 studies screened, 26 (24 unique cohorts) were included in the qualitative analysis and 16 (15 unique cohorts) were included in the quantitative analysis. Results: Across studies, higher perceived stress was significantly associated with an increased risk of mild cognitive impairment (Cases/Total N = 207/860: hazard ratio [HR] = 1.19, 95% confidence interval [CI] = 1.03–1.38) and all-cause dementia (Cases/Total N = 203/1,882: HR = 1.44, 95% CI = 1.07–1.95). Exposure to two or more stressful life events (versus none) was significantly associated with an increased risk of all-cause dementia (Cases/Total N = 3,354/11,597: HR = 1.72, 95% CI = 1.14–2.60), while one or more stressful life events was not. Higher neuroticism was significantly associated with an increased risk of Alzheimer’s disease dementia (Cases/Total N = 497/4,771: HR = 1.07, 95% CI = 1.01–1.12), but not all-cause dementia. Conclusion: This review suggests that psychological stress in adulthood is associated with an increased risk of dementia. Further research is needed to clarify the mechanisms underlying these associations.

scholarly journals Maternal Stressful Life Events During the Periconceptional Period and Orofacial Clefts: A Systematic Review and Meta-Analysis

2022 ◽  
pp. 105566562110455
Author(s):  
Christina Tran ◽  
Andrew A. Crawford ◽  
Alexander Hamilton ◽  
Clare E. French ◽  
Yvonne Wren ◽  
...  
Keyword(s):  
Systematic Review ◽  
Life Events ◽  
Cleft Lip ◽  
Stressful Life Events ◽  
Meta Analysis ◽  
Positive Association ◽  
Population Level ◽  
Risk Of Bias ◽  
Stressful Life ◽  
Periconceptional Period

Objective To assess whether women who experience stressful life events during the periconceptional period are at higher risk of giving birth to a baby with an orofacial cleft (OFC). Design Systematic review and meta-analysis of studies reporting the proportion of babies born with OFC to mothers exposed and unexposed to population-level or personal-level stressful life events during the periconceptional period. Six electronic databases were searched from inception to August 2020. Risk of bias was assessed using the Newcastle-Ottawa scale. Odds ratios (ORs) for the odds of OFC in babies of exposed mothers relative to unexposed controls were extracted and/or calculated. Random effects meta-analysis was undertaken, stratified by cleft subtype. Results Of 12 eligible studies, 8 examined experience of personal events and 4 examined population-level events. Studies demonstrated low-moderate risk of bias and there was indication of publication bias. There was some evidence that personal stressful life events were associated with greater odds of cleft lip and/or palate (six studies, OR 1.63, 95% confidence interval (CI) 1.16, 2.30, P = 0.001) and cleft palate only (six studies, OR 1.45, 95% CI 1.02, 2.06, P = 0.04). Population-level events were associated with higher odds of OFC in studies that did not specify subtype (three studies, OR 1.64, 95% CI 1.19, 2.25, P = 0.002), but subtype stratified analyses were underpowered. Heterogeneity was high. Conclusions Limited evidence indicated a weak positive association between maternal stressful life events during the periconceptional period and risk of OFC in the offspring, but further studies with greater consistency in research design are needed.

The Impact of Prenatal Stressful Life Events on Adverse Birth Outcomes:a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Xiuxiu Ding ◽  
Mingming Liang ◽  
Yile Wu ◽  
Tianming Zhao ◽  
Guangbo Qu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Life Events ◽  
Stressful Life Events ◽  
Meta Analysis ◽  
Stressful Life ◽  
The Impact
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