Effects of post-exercise recovery in a cold environment on muscle glycogen, PGC-1α, and downstream transcription factors

Background: Capsinoids (CSN), the novel non-pungent capsaicin analogs have been reported to promote metabolic health and exercise tolerance. However, the effect of CSN on fat oxidation and changes in skeletal muscle glycogen levels during post-exercise recovery has not been investigated in humans. Purpose: We examined the effect of CSN supplementation on energy reliance, glycogen resynthesis and molecular proteins in the skeletal muscle of young adults during post-exercise recovery. Methods: In this crossover-designed study, nine healthy adult male volunteers (aged 21.4±0.2 years, BMI 21.9±1.3 kg/m2 ) completed a 60-min cycling exercise at 70% VO2max. Participants consumed either CSN (12 mg, single dosage) or placebo capsules with a high-carbohydrate meal (2 g carb/kg bodyweight) immediately after exercise. Biopsied muscle samples (vastus lateralis), blood and gaseous samples were obtained during 3h post-exercise recovery period. Results: We found that oral CSN supplementation right after exercise significantly altered the energy reliance on fat oxidation during recovery. This was evidenced by lower respiratory exchange ratio (RER) and higher fat oxidation rate in CSN trial. Despite, acute CSN dosage does not contribute to enhance the glycogen replenishment in skeletal muscle during 3h recovery. We identified no significant differences in postprandial glucose and insulin area under the curve in both trials. Western blot data showed increased muscle GLUT4 expression, but no significant response of p-Akt/Akt ratio with CSN during post-exercise recovery. Conclusion: Our findings conclude that acute CSN intake could change energy reliance on fat oxidation, but unable to enhance muscle glycogen resynthesis during post-exercise recovery. Thus, ergogenic properties of CSN in relevance to muscle glycogen restoration following exercise needs to be further investigated in young adults.

Download Full-text

Effect Of Ambient Oxygen Status On Liver And Muscle Glycogen Storages During Post-exercise Recovery Period

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000274120.08734.51 ◽

2007 ◽

Vol 39 (Supplement) ◽

pp. S290

Author(s):

Wen-Chih Lee ◽

Wei-Shiang Lin ◽

Mei-Chih Chen ◽

Jung-Shi Wang ◽

Kuo-Lung Ho ◽

...

Keyword(s):

Muscle Glycogen ◽

Recovery Period ◽

Exercise Recovery ◽

Post Exercise ◽

Ambient Oxygen ◽

Post Exercise Recovery ◽

Oxygen Status

Download Full-text

Effect Of Ambient Oxygen Status On Muscle Glycogen, AMPK, CAMKII And GLUT4 Protein Expression During Post-exercise Recovery Period

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000384577.24794.97 ◽

2010 ◽

Vol 42 ◽

pp. 326

Author(s):

Wen-Chih Lee ◽

Yang Sun-Chin ◽

Cheng-Feng Ho ◽

Chieh-Ling Wang ◽

John L. Ivy ◽

...

Keyword(s):

Protein Expression ◽

Muscle Glycogen ◽

Recovery Period ◽

Exercise Recovery ◽

Post Exercise ◽

Ambient Oxygen ◽

Post Exercise Recovery ◽

Oxygen Status

Download Full-text

The Effect of Consuming Carbohydrate With and Without Protein on the Rate of Muscle Glycogen Re-synthesis During Short-Term Post-exercise Recovery: a Systematic Review and Meta-analysis

Sports Medicine - Open ◽

10.1186/s40798-020-00297-0 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Jonathan Craven ◽

Ben Desbrow ◽

Surendran Sabapathy ◽

Phillip Bellinger ◽

Danielle McCartney ◽

...

Keyword(s):

Systematic Review ◽

Muscle Glycogen ◽

Meta Analysis ◽

Strenuous Exercise ◽

Synthesis Rate ◽

Exercise Recovery ◽

Short Term ◽

Additional Measure ◽

Post Exercise ◽

Post Exercise Recovery

Abstract Background Rapid restoration of muscle glycogen stores is imperative for athletes undertaking consecutive strenuous exercise sessions with limited recovery time (e.g. ≤ 8 h). Strategies to optimise muscle glycogen re-synthesis in this situation are essential. This two-part systematic review and meta-analysis investigated the effect of consuming carbohydrate (CHO) with and without protein (PRO) on the rate of muscle glycogen re-synthesis during short-term post-exercise recovery (≤ 8 h). Methods Studies were identified via the online databases Web of Science and Scopus. Investigations that measured muscle glycogen via needle biopsy during recovery (with the first measurement taken ≤ 30 min post-exercise and at least one additional measure taken ≤ 8 h post-exercise) following a standardised exercise bout (any type) under the following control vs. intervention conditions were included in the meta-analysis: part 1, water (or non-nutrient beverage) vs. CHO, and part 2, CHO vs. CHO+PRO. Publications were examined for methodological quality using the Rosendal scale. Random-effects meta-analyses and meta-regression analyses were conducted to evaluate intervention efficacy. Results Overall, 29 trials (n = 246 participants) derived from 21 publications were included in this review. The quality assessment yielded a Rosendal score of 61 ± 8% (mean ± standard deviation). Part 1: 10 trials (n = 86) were reviewed. Ingesting CHO during recovery (1.02 ± 0.4 g·kg body mass (BM)−1 h−1) improved the rate of muscle glycogen re-synthesis compared with water; change in muscle glycogen (MGΔ) re-synthesis rate = 23.5 mmol·kg dm−1 h−1, 95% CI 19.0–27.9, p < 0.001; I2 = 66.8%. A significant positive correlation (R2 = 0.44, p = 0.027) was observed between interval of CHO administration (≤ hourly vs. > hourly) and the mean difference in rate of re-synthesis between treatments. Part 2: 19 trials (n = 160) were reviewed. Ingesting CHO+PRO (CHO: 0.86 ± 0.2 g·kg BM−1 h−1; PRO: 0.27 ± 0.1 g·kg BM−1 h−1) did not improve the rate of muscle glycogen re-synthesis compared to CHO alone (0.95 ± 0.3 g·kg BM−1 h−1); MGΔ re-synthesis rate = 0.4 mmol·kg dm−1 h−1, 95% CI −2.7 to 3.4, p = 0.805; I2 = 56.4%. Conclusions Athletes with limited time for recovery between consecutive exercise sessions should prioritise regular intake of CHO, while co-ingesting PRO with CHO appears unlikely to enhance (or impede) the rate of muscle glycogen re-synthesis. Trial Registration Registered at the International Prospective Register of Systematic Reviews (PROSPERO) (identification code CRD42020156841).

Download Full-text

Application of Protein or Protein Hydrolysates to Improve Postexercise Recovery

International Journal of Sport Nutrition and Exercise Metabolism ◽

10.1123/ijsnem.17.s1.s104 ◽

2007 ◽

Vol 17 (s1) ◽

pp. S104-S117 ◽

Cited By ~ 11

Author(s):

Luc J.C. van Loon

Keyword(s):

Amino Acids ◽

Protein Synthesis ◽

Muscle Glycogen ◽

Muscle Protein ◽

Protein Hydrolysates ◽

Exercise Recovery ◽

Protein Balance ◽

Post Exercise ◽

Glycogen Repletion ◽

Post Exercise Recovery

Protein, protein hydrolysates, and amino acids have become popular ingredients in sports nutrition. The use of protein, protein hydrolysates, and amino acid mixtures has multiple applications when aiming to improve post exercise recovery. After exhaustive endurance-type exercise, muscle glycogen repletion is the most important factor determining the time needed to recover. Coingestion of relatively small amounts of protein and/or amino acids with carbohydrate can be used to augment postprandial insulin secretion and accelerate muscle glycogen synthesis rates. Furthermore, it has been well established that ingesting protein, protein hydrolysates, and amino acid can stimulate protein synthesis and inhibit protein breakdown and, as such, improve net muscle protein balance after resistance- or endurance-type exercise. The latter has been suggested to lead to a more effective adaptive response to each successive exercise bout. To augment net muscle protein accretion, athletes involved in resistance-type exercise generally ingest both protein and carbohydrate during post exercise recovery. However, carbohydrate ingestion after resistance-type exercise does not seem to be warranted to further stimulate muscle protein synthesis or improve whole-body protein balance when ample protein has already been ingested. Because resistance-type exercise is also associated with a substantial reduction in muscle glycogen content, it would be preferred to coingest some carbohydrate when aiming to accelerate glycogen repletion. More research is warranted to assess the impact of ingesting different proteins, protein hydrolysates, and/or amino acids on muscle protein accretion after exercise.

Download Full-text

Post-Exercise Recovery: Fundamental and Interventional Physiology

10.3389/978-2-88919-855-9 ◽

2016 ◽

Keyword(s):

Exercise Recovery ◽

Post Exercise ◽

Post Exercise Recovery

Download Full-text

Relationship of Carbohydrate Intake during a Single-Stage One-Day Ultra-Trail Race with Fatigue Outcomes and Gastrointestinal Problems: A Systematic Review

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18115737 ◽

2021 ◽

Vol 18 (11) ◽

pp. 5737

Author(s):

Soledad Arribalzaga ◽

Aitor Viribay ◽

Julio Calleja-González ◽

Diego Fernández-Lázaro ◽

Arkaitz Castañeda-Babarro ◽

...

Keyword(s):

Systematic Review ◽

Single Stage ◽

Cochrane Library ◽

Exercise Recovery ◽

Post Exercise ◽

Exercise Load ◽

Gi Symptoms ◽

Gastrointestinal Problems ◽

Exercise Induced ◽

Post Exercise Recovery

Due to the high metabolic and physical demands in single-stage one-day ultra-trail (SOUT) races, athletes should be properly prepared in both physical and nutritional aspects in order to delay fatigue and avoid associated difficulties. However, high carbohydrate (CHO) intake would seem to increase gastrointestinal (GI) problems. The main purpose of this systematic review was to evaluate CHO intake during SOUT events as well as its relationship with fatigue (in terms of internal exercise load, exercise-induced muscle damage (EIMD) and post-exercise recovery) and GI problems. A structured search was carried out in accordance with PRISMA guidelines in the following: Web of Science, Cochrane Library and Scopus databases up to 16 March 2021. After conducting the search and applying the inclusion/exclusion criteria, eight articles in total were included in this systematic review, in all of which CHO intake involved gels, energy bars and sports drinks. Two studies associated higher CHO consumption (120 g/h) with an improvement in internal exercise load. Likewise, these studies observed that SOUT runners whose intake was 120 g/h could benefit by limiting the EIMD observed by CK (creatine kinase), LDH (lactate dehydrogenase) and GOT (aspartate aminotransferase), and also improve recovery of high intensity running capacity 24 h after a trail marathon. In six studies, athletes had GI symptoms between 65–82%. In summary, most of the runners did not meet CHO intake standard recommendations for SOUT events (90 g/h), while athletes who consumed more CHO experienced a reduction in internal exercise load, limited EIMD and improvement in post-exercise recovery. Conversely, the GI symptoms were recurrent in SOUT athletes depending on altitude, environmental conditions and running speed. Therefore, a high CHO intake during SOUT events is important to delay fatigue and avoid GI complications, and to ensure high intake, it is necessary to implement intestinal training protocols.

Download Full-text