cold environment
Recently Published Documents


TOTAL DOCUMENTS

469
(FIVE YEARS 75)

H-INDEX

28
(FIVE YEARS 5)

Author(s):  
Shruti Pathania ◽  
Preeti Solanki ◽  
Chayanika Putatunda ◽  
Ravi Kant Bhatia ◽  
Abhishek Walia

2021 ◽  
Vol 1 (2) ◽  
pp. 95-101
Author(s):  
Hui Yu ◽  
Yun Zhou ◽  
Yu Duan ◽  
Yunlong Gao ◽  
Ning Fang ◽  
...  

Abstract Objective Cold exposure is associated with increased prevalence of hypertension and the related severe cardiovascular events. Aberrant activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays an important role in the development of hypertension. Tranilast (TR), an inhibitor of NLRP3, provides a useful pharmacological probe for exploring the role of NLRP3 in pathogenesis associated with inflammation and its potential application as a therapeutic agent. This study was designed to examine the effects of TR on NLRP3 and hypertension in rats exposed to cold environment to simulate the frigid-zone conditions. Methods and results Sprague Dawley (SD) rats were exposed to moderate cold temperature (4±1°C), and then were randomized to receive TR or vehicle for 3 weeks, while the control group was raised under rat room temperature (RT, 23±1°C). We found that cold exposure substantially increased blood pressure, NLRP3 inflammasome level, and fibrosis in aorta, which were reversed by TR. Conclusion TR has an anti-hypertensive property in cold environment, and this beneficial action is likely conferred by its inhibitory effects on inflammation and fibrosis. These findings suggest TR as a potential drug for the treatment of cold-induced hypertension.


Author(s):  
Rasmus I. P. Valtonen ◽  
Heidi H. E. Hintsala ◽  
Antti Kiviniemi ◽  
Tuomas Kenttä ◽  
Craig Crandall ◽  
...  

Abstract Purpose Upper-body exercise performed in a cold environment may increase cardiovascular strain, which could be detrimental to patients with coronary artery disease (CAD). This study compared cardiovascular responses of CAD patients during graded upper-body dynamic and static exercise in cold and neutral environments. Methods 20 patients with stable CAD performed 30 min of progressive dynamic (light, moderate, and heavy rating of perceived exertion) and static (10, 15, 20, 25 and 30% of maximal voluntary contraction) upper body exercise in cold (− 15 °C) and neutral (+ 22 °C) environments. Heart rate (HR), blood pressure (BP) and electrocardiographic (ECG) responses were recorded and rate pressure product (RPP) calculated. Results Dynamic-graded upper-body exercise in the cold increased HR by 2.3–4.8% (p = 0.002–0.040), MAP by 3.9–5.9% (p = 0.038–0.454) and RPP by 18.1–24.4% (p = 0.002–0.020) when compared to the neutral environment. Static graded upper-body exercise in the cold resulted in higher MAP (6.3–9.1%; p = 0.000–0.014), lower HR (4.1–7.2%; p = 0.009–0.033), but unaltered RPP compared to a neutral environment. Heavy dynamic exercise resulted in ST depression that was not related to temperature. Otherwise, ECG was largely unaltered during exercise in either thermal condition. Conclusions Dynamic- and static-graded upper-body exercise in the cold involves higher cardiovascular strain compared with a neutral environment among patients with stable CAD. However, no marked changes in electric cardiac function were observed. The results support the use of upper-body exercise in the cold in patients with stable CAD. Trial registration Clinical trial registration NCT02855905 August 2016.


2021 ◽  
Vol 9 (10) ◽  
pp. 2605-2608
Author(s):  
Lekha Soni ◽  
Pramod Kumar Mishra ◽  
Indu Sharma ◽  
Garima Yadav

In Urticaria Vata and Kapha are two doshas that are primarily vitiated and being mixed with pitta (Pittena Saha Sambhooya) spreads internally and Externally (Bahir Aantah Visarpah) and results in to ‘Shittapitta-Udarda-Ko- tha’1. Due to Pitta dosha they create redness, swelling on the skin and moderate to severe itching on the skin. Ayurveda Herbo minerals preparation cures urticaria by balancing Tridoshas in the body. Shittapitta manifests due to exposure to various poisonous materials (allergens), cold environment and intake of Asatmya Ahar Vihar. In modern science, it is compared with urticaria. Hives (urticaria) are red, itchy welts that occur when the skin meets allergen releases histamine and other chemicals. The welts vary in size, appear and then disappear repeatedly as the reaction runs its course. The condition is considered chronic hives if the welts appear for more than six weeks and recur frequently over months or years. Episodes of urticaria may relapse for days, weeks, months or years. In Ayur- veda Herbo-minerals preparation effectively treat Shittapitta and restore healthy skin by balancing Tridosha and Sapta dhatu in the body. Keywords Urticaria, Shittapitta, Dosha, Tridosha, hives


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Davide Bottone ◽  
Valentina Donadei ◽  
Henna Niemelä ◽  
Heli Koivuluoto ◽  
Stefan Seeger

AbstractPassive icephobic surfaces can provide a cost and energy efficient solution to many icing problems that are currently handled with expensive active strategies. Water-repellent surface treatments are promising candidates for this goal, but commonly studied systems, such as superhydrophobic surfaces and Slippery Liquid Infused Porous Surfaces (SLIPS), still face challenges in the stability and durability of their properties in icing environments. In this work, environmental icing conditions are simulated using an Icing Wind Tunnel, and ice adhesion is evaluated with a Centrifugal Adhesion Test. We show that superhydrophobic coral-like Silicone Nanofilament (SNF) coatings exhibit extremely low ice adhesion, to the point of spontaneous ice detachment, and good durability against successive icing cycles. Moreover, SNFs-based SLIPS show stably low ice adhesion for the whole duration of the icing test. Stability of surface properties in a cold environment is further investigated with water wettability at sub-zero surface temperature, highlighting the effect of surface chemistry on superhydrophobicity under icing conditions.


2021 ◽  
Vol 7 (3) ◽  
pp. 7-13
Author(s):  
R. S. Rakhmanov ◽  
E. S. Bogomolov ◽  
D. A. Narutdinov ◽  
S. A. Razgulin ◽  
M. V. Ashina

Aim. Assess the health risk of a cold environment by bioclimatic indices characterizing weather and climatic conditions in the Arctic zone of the Krasnoyarsk Territory.Materials and methods. The mean monthly daily ambient temperature, wind speed and relative air humidity were determined. The body cooling conditions integral index (BCCII) and the wind-cold index (WCI) were calculated.Results and their discussion. Using the BCCII from 4 to 6 months a year at Cape Chelyuskin, the critical risk of frostbite in exposed areas of the body determined at Dixon Island from 4 to 5 months a year; in July and August, the indicator values reached the lower border of the “moderate risk”. Using the WCI, an uncomfortable cold environment was determined, respectively, 2 months and 4 months, a very cold — 3 months and 2 months, and an extremely cold — 3 months and 2 months.Conclusion. The advantage of using BCCII rather than WCI is shown, since on its basis the criteria for safe working conditions in an open area are determined. To interpret the value of “no risk” while using WCI, it is necessary to know the period of the year, in which the weather and climatic conditions are assessed as a cold environment.


2021 ◽  
pp. 108429
Author(s):  
Guangju Liu ◽  
Yun Su ◽  
Wen Zhu ◽  
Miao Tian ◽  
Jun Li ◽  
...  

Radiocarbon ◽  
2021 ◽  
pp. 1-16
Author(s):  
Kyeong J Kim ◽  
Ju Y Kim ◽  
Kyong W Lee ◽  
Seung W Lee ◽  
Jong Y Woo ◽  
...  

ABSTRACT The Suyanggae archeological complex is located in Aegok-li, Danyang County, Chungbuk Province, Korea (128°20'00"E, 365˚7'15"N, elevation 132 m). We investigated two Suyanggae Paleolithic localities (1 and 6). A total of 31 samples (18 localities) were analyzed for radiocarbon (14C) ages in three paleolithic cultural horizons of Suyanggae Locality 6 (SYG-6). The purpose of this paper is to report all dating results of SYG-6. It was found that ranges of 14C ages (BP) of cultural layers of SYG-6 are known to be 17,550 ± 80 ∼ 20,470 ± 70, 30,360 ± 350 ∼ 44,100 ± 1900, and 34,870 ± 540 ∼ 46,360 ± 510 BP for cultural layers 2, 3, and 4, respectively. We compared these age data with those of the previous study associated with Gunang Cave near Suyanggae Locality 1 (SYG-1). Based on the chronological information of the three archaeological sites, early humans lived in a rather cold environment from approximately 30,000 to 46,000 BP and disappeared between 30,000 ∼ 20,000 BP and then settled again in SYG-6 site during LGM period. This study demonstrates that archaeological study is important not only for understanding human occupations with their cultural development but also establishing climatic signals to which they have been adapted as a part of the human evolutional process.


Sign in / Sign up

Export Citation Format

Share Document