Cryopreservation of Thymic Tissue As A Cellular Therapy For The Reconstitution of Immunity

Infection of newborn mice with Moloney leukemia virus (M-MuLV) causes a T-cell differentiation block in the thymic cortex accompanied by proliferation and accumulation of prethymic lymphoblasts in the thymus and subsequent spreading of these cells to generate systemic lymphoma. Current evidence shows that thymic reticular epithelial cells (REC) provide a microenvironment necessary for the maturation of prethymic lymphoblasts to mature T-lymphocytes by secretion of various thymic factors. A change in that environment due to infection of REC by virus could be decisive for the failure of lymphoblasts to mature and thus contribute to lymphoma development.We have studied the morphology and distribution of the major thymic cell populations at different stages of tumorigenesis in Balb/c mice infected when newborn with 0.2ml M-MuLV suspension, 6.8 log FFU/ml. Thymic tissue taken at 1-2 weekly intervals up to tumor development was processed for light and electron microscopy, using glutaraldehyde-OsO4fixation and Epon-Araldite embedding.

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Treating depressive behaviors with cellular therapy in female rats with brain injury

PsycEXTRA Dataset ◽

10.1037/e516222012-032 ◽

2010 ◽

Author(s):

O.R. Fedotova ◽

T.V. Avaliani ◽

I.B. Sokolova

Keyword(s):

Brain Injury ◽

Cellular Therapy ◽

Female Rats

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Skin and corneal cellular therapy using embryonic stem cells: how far are we?

Expert Review of Dermatology ◽

10.1586/17469872.3.3.357 ◽

2008 ◽

Vol 3 (3) ◽

pp. 357-366 ◽

Cited By ~ 1

Author(s):

Ruby Shalom-Feuerstein ◽

Daniel Aberdam

Keyword(s):

Stem Cells ◽

Embryonic Stem Cells ◽

Cellular Therapy ◽

Embryonic Stem

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Chimeric antigen receptor T in the treatment of multiple myeloma – state of the art and future directions

Acta Haematologica Polonica ◽

10.2478/ahp-2020-0023 ◽

2020 ◽

Vol 51 (3) ◽

pp. 120-124

Author(s):

Dominik Dytfeld

Keyword(s):

Multiple Myeloma ◽

Chimeric Antigen Receptor ◽

Cellular Therapy ◽

New Technology ◽

Phase 1 ◽

Antigen Receptor ◽

New Drugs ◽

Adoptive Cellular Therapy ◽

B Cell Maturation ◽

Complexity Cost

AbstractIn spite of the introduction of several new drugs in the last 10 years, multiple myeloma (MM) remains incurable. Thus, an adoptive cellular therapy using chimeric antigen receptor T (CART), a strategy to increase the frequency of tumor-directed and functionally active T cells targeting antigens present on the cancer cell, might change the treatment in MM as it did in lymphoma and ALL. There are several targets for CART therapy in MM on different levels of development, which are discussed in the manuscript. B-cell maturation antigen (BCMA) being tested in the studies of phase 1–2 is the most promising, but so far CART has not been approved in the cure of MM and remains an experimental approach. The hematological society is facing a new technology which with its potential ability to cure MM, in spite of its complexity, cost, and toxicity, will definitely and soon change the landscape of myeloma in Europe and world-wide.

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Novel Coronavirus SARS-CoV-2 (COVID-19) and Pregnancy: A hypothetical view

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530320666201023124843 ◽

2020 ◽

Vol 20 ◽

Author(s):

Ahmed RG

Keyword(s):

Immune System ◽

Cellular Therapy ◽

Early Stage ◽

Control Strategies ◽

Vital Role ◽

Healthy Life ◽

Global Pandemic ◽

Maternal Immune System ◽

Perinatal Management ◽

Novel Coronavirus

Background: The complications of the SARS-CoV-2 infection and its COVID-19 disease on mothers and their offspring are less known. Objective: The aim of this review was to determine the transmission, severity, complications of SARS-CoV-2 infection during the pregnancy. This review showed the influence of COVID-19 disease on the neonatal neurogenesis. Owing to no specific vaccines or medicines that were reported for the treatment of COVID-19 disease, this review suggested some control strategies like treatments (medicinal plants, antiviral therapy, cellular therapy, and immunotherapy), nutrition uptake, prevention, and recommendations. Discussion: This overview showed in severely states that SARS-CoV-2 infection during the early stage of pregnancy might increase the risk of stress, panic, and anxiety. This disorder can disturb the maternal immune system, and thus causing a neurodevelopmental disturbance. This hypothesis may be depending on the severity and intensity of the SARS-CoV-2 infection during pregnancy. However, vertical transmission of SARS-CoV-2 from dams to their fetuses is absent until now. Conclusion: During this global pandemic disease, maintaining safety during pregnancy, vaginal delivery, and breastfeeding may play a vital role in a healthy life for the offspring. Thus, international and national corporations should be continuing for perinatal management, particularly during the next pandemic or disaster time.

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