New normalization methods using support vector machine quantile regression approach in microarray analysis

2008 ◽  
Vol 52 (8) ◽  
pp. 4104-4115 ◽  
Author(s):  
Insuk Sohn ◽  
Sujong Kim ◽  
Changha Hwang ◽  
Jae Won Lee
Author(s):  
Junwei Ma ◽  
Xiao Liu ◽  
Xiaoxu Niu ◽  
Yankun Wang ◽  
Tao Wen ◽  
...  

Data-driven models have been extensively employed in landslide displacement prediction. However, predictive uncertainty, which consists of input uncertainty, parameter uncertainty, and model uncertainty, is usually disregarded in deterministic data-driven modeling, and point estimates are separately presented. In this study, a probability-scheme combination ensemble prediction that employs quantile regression neural networks and kernel density estimation (QRNNs-KDE) is proposed for robust and accurate prediction and uncertainty quantification of landslide displacement. In the ensemble model, QRNNs serve as base learning algorithms to generate multiple base learners. Final ensemble prediction is obtained by integration of all base learners through a probability combination scheme based on KDE. The Fanjiaping landslide in the Three Gorges Reservoir area (TGRA) was selected as a case study to explore the performance of the ensemble prediction. Based on long-term (2006–2018) and near real-time monitoring data, a comprehensive analysis of the deformation characteristics was conducted for fully understanding the triggering factors. The experimental results indicate that the QRNNs-KDE approach can perform predictions with perfect performance and outperform the traditional backpropagation (BP), radial basis function (RBF), extreme learning machine (ELM), support vector machine (SVM) methods, bootstrap-extreme learning machine-artificial neural network (bootstrap-ELM-ANN), and Copula-kernel-based support vector machine quantile regression (Copula-KSVMQR). The proposed QRNNs-KDE approach has significant potential in medium-term to long-term horizon forecasting and quantification of uncertainty.


2012 ◽  
Vol 45 (6) ◽  
pp. 2280-2287 ◽  
Author(s):  
K. De Brabanter ◽  
P. Karsmakers ◽  
J. De Brabanter ◽  
J.A.K. Suykens ◽  
B. De Moor

2015 ◽  
Vol 42 (13) ◽  
pp. 5441-5451 ◽  
Author(s):  
Qifa Xu ◽  
Jinxiu Zhang ◽  
Cuixia Jiang ◽  
Xue Huang ◽  
Yaoyao He

2012 ◽  
Vol 160 ◽  
pp. 313-317
Author(s):  
Xu Chao Shi ◽  
Qi Xia Liu ◽  
Xiu Juan Lv

Support Vector Machine is a powerful machine learning technique based on statistical learning theory. This paper investigates the potential of support vector machines based regression approach to model the strength of cement stabilized soil from test dates. Support Vector Machine model is proposed to predict compressive strength of cement stabilized soil. And the effects of selecting kernel function on Support Vector Machine modeling are also analyzed. The results show that the Support Vector Machine is more precise in measuring the strength of cement than traditional methods. The Support Vector Machine method has advantages in its simple structure,excellent capability in studying and good application prospects, also it provide us with a novel method of measuring the strength of cement stabilized soil.


2008 ◽  
Vol 47 (05) ◽  
pp. 459-467 ◽  
Author(s):  
S. Kim ◽  
C. Hwang ◽  
J. W. Lee ◽  
J. Shim ◽  
I. Sohn

Summary Objectives: One of the main objectives of microarray analysis is to identify genes differentially expressed under two distinct experimental conditions. This task is complicated by the noisiness of data and the large number of genes that are examined. Fold change (FC) based gene selection often misleads because error variability for each gene is heterogeneous in different intensity ranges. Several statistical methods have been suggested, but some of them result in high false positive rates because they make very strong parametric assumptions. Methods: We present support vector quantile regression (SVMQR) using iterative reweighted least squares (IRWLS) procedure based on the Newton method instead of usual quadratic programming algorithms. This procedure makes it possible to derive the generalized approximate cross validation (GACV) method for choosing the parameters which affect the performance of SVMAR. We propose SVMQR based on a novel method for identifying differentially expressed genes with a small number of replicated microarrays. Results: We applied SVMQR to both three biological dataset and simulated dataset and showed that it performed more reliably and consistently than FC-based gene selection, Newton’s method based on the posterior odds of change, or the nonparametric t-test variant implemented in significance analysis of microarrays (SAM). Conclusions: The SVMQR method was an exploratory method for cDNA microarray experiments to identify genes with different expression levels between two types of samples (e.g., tumor versus normal tissue). The SVMQR method performed well in the situation where error variability for each gene was heterogeneous in intensity ranges.


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