Long-term consequence of polycystic ovarian syndrome

AbstractPolycystic ovarian syndrome (PCOS) is the most common endocrinopathy in women and can be associated with significant adverse sequelae that can affect overall long-term health and well-being. This review provides a succinct but comprehensive overview of our current understanding concerning the known morbidities of PCOS, beginning with a review of the importance of the different phenotypes of PCOS in determining long-term morbidity, the confounding impact of obesity on health outcomes in PCOS, and the immediate short-term consequences of the disorder (including dermatologic, reproductive, and mood disturbances). The longer-term morbidities of PCOS are then reviewed including metabolic consequences (impaired glucose tolerance and type 2 diabetes mellitus, metabolic syndrome, and nonalcoholic fatty liver disease), dyslipidemia and vascular dysfunction (including hypertension and increased incidences of cerebrovascular accidents and thromboembolisms on oral contraceptives), neoplastic (primarily endometrial adenocarcinoma), and mental health disorders (including greater incidences of depressive and anxiety disturbances and psychosexual dysfunction). In conclusion, strategies for the prevention and amelioration of long-term morbidities in PCOS are presented.

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Long-term Sequel of Polycystic Ovarian Syndrome

Decoding Polycystic Ovarian Syndrome (PCOS) ◽

10.5005/jp/books/13089_15 ◽

2018 ◽

pp. 180-180

Author(s):

Anu Agarwal

Keyword(s):

Polycystic Ovarian Syndrome ◽

Ovarian Syndrome

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Short Review on Polycystic Ovarian Syndrome

Journal of Medicine ◽

10.3329/jom.v19i1.34843 ◽

2017 ◽

Vol 19 (1) ◽

pp. 49-53

Author(s):

Rabia Farooq

Keyword(s):

Polycystic Ovarian Syndrome ◽

Endocrine System ◽

Short Review ◽

Reproductive Age ◽

Women Of Reproductive Age ◽

The World ◽

Long Time ◽

System Disorder ◽

Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is a metabolic disease and a common endocrine system disorder among women of reproductive age. Infrequent or prolonged menstrual periods, excess hair growth, acne, and obesity can occur in women with PCOS. Early diagnosis and treatment along with weight loss may reduce the risk of long-term complications. Now a days PCOS is also the cause of infertility. India is PCOS capital of the world. PCOS management is necessary to reduce its long time complications.J MEDICINE Jan 2018; 19 (1) : 49-53

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From Placenta to Polycystic Ovarian Syndrome: The Role of Adipokines

Mediators of Inflammation ◽

10.1155/2016/4981916 ◽

2016 ◽

Vol 2016 ◽

pp. 1-14 ◽

Cited By ~ 14

Author(s):

Chiara Sartori ◽

Pietro Lazzeroni ◽

Silvia Merli ◽

Viviana Dora Patianna ◽

Francesca Viaroli ◽

...

Keyword(s):

Polycystic Ovarian Syndrome ◽

Mononuclear Cells ◽

Reproductive Function ◽

Childhood And Adolescence ◽

Long Term Effects ◽

Peripheral Blood Mononuclear ◽

The Metabolic Syndrome ◽

Pregnancy And Lactation ◽

Ovarian Syndrome

Adipokines are cytokines produced mainly by adipose tissue, besides many other tissues such as placenta, ovaries, peripheral-blood mononuclear cells, liver, muscle, kidney, heart, and bone marrow. Adipokines play a significant role in the metabolic syndrome and in cardiovascular diseases, have implications in regulating insulin sensitivity and inflammation, and have significant effects on growth and reproductive function. The objective of this review was to analyze the functions known today of adiponectin, leptin, resistin, and visfatin from placenta throughout childhood and adolescence. It is well known now that their serum concentrations during pregnancy and lactation have long-term effects beyond the fetus and newborn. With regard to puberty, adipokines are involved in the regulation of the relationship between nutritional status and normal physiology or disorders of puberty and altered gonadal function, as, for example, premature pubarche and polycystic ovarian syndrome (PCOS). Cytokines are involved in the maturation of oocytes and in the regular progression of puberty and pregnancy.

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Long-term naltrexone* treatment normalizes the pituitary response to gonadotropin-releasing hormone in polycystic ovarian syndrome†*Antaxone Zambon, Milano, Italy.†Supported by grant 88.00479.11 from the Consiglio Nazionale delle Ricerche, Roma, Italy.

Fertility and Sterility ◽

10.1016/s0015-0282(16)55851-8 ◽

1993 ◽

Vol 59 (4) ◽

pp. 734-737 ◽

Cited By ~ 18

Author(s):

Antonio Lanzone ◽

Rosanna Apa ◽

Anna Maria Fulghesu ◽

Giuseppe Cutillo ◽

Alessandro Caruso ◽

...

Keyword(s):

Polycystic Ovarian Syndrome ◽

Gonadotropin Releasing Hormone ◽

Releasing Hormone ◽

Naltrexone Treatment ◽

Consiglio Nazionale Delle Ricerche ◽

Ovarian Syndrome

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Study on the Prevalence and Characteristics of Metabolic Syndrome in Women of Reproductive Age Group with Polycystic Ovarian Syndrome

Journal of SAFOG with DVD ◽

10.5005/jp-journals-10006-1526 ◽

2017 ◽

Vol 9 (4) ◽

pp. 341-347

Author(s):

Rekha R Madusudhanan ◽

Bindu Nambisan ◽

Mayadevi Brahmanandan ◽

Sreekumari Radha

Keyword(s):

Metabolic Syndrome ◽

Polycystic Ovarian Syndrome ◽

Significant Risk ◽

Significant Risk Factor ◽

Reproductive Age ◽

Age Group ◽

Women Of Reproductive Age ◽

Ovarian Syndrome ◽

Reproductive Age Group

ABSTRACT Introduction Polycystic ovarian syndrome (PCOS) is an endocrine disorder affecting all age groups and presenting with myriad problems like menstrual irregularities, hirsutism, anovulatory infertility, and long-term complications like diabetes, cardiovascular problems, etc. Aim Study was aimed at finding the prevalence, characteristics, and various risk factors of metabolic syndrome (MS) in reproductive age group in our hospital. Materials and methods Using statistical table, a sample size of 131 was calculated and patients were recruited as per inclusion criteria. Polycystic ovarian syndrome was diagnosed by the American Society for Reproductive Medicine (ASRM)/European Society of Human Reproduction and Embryology (ESHRE) criteria. After informed consent, a detailed history was obtained and physical examination was carried out to assess, body weight, height, body mass index (BMI), waist—hip ratio (WHR), and blood pressure (BP). Fasting blood glucose, triglycerides, and high-density lipoprotein (HDL) were measured for each woman Results Prevalence of MS in our study was 45.8%; 26.7% of patients had a combination of increased waist circumference, raised triglycerides, and low HDL; 55.2% of patients had a fasting blood sugar (FBS) levels more than 100 mg%. Age of the patient was a statistically significant risk factor of MS with 100% of patients in the age group of 35 to 39 presenting with MC. Body mass index was also a statistically significant risk factor with 82.6% with BMI > 30 having MC. Other important risk factors include a WHR more than 0.95, presence of diabetes in mother or sister, and presence of acanthosis; 71% of patients with WHR more than 0.95 had MC. Age of menarche, duration of menstrual cycles, and hirsutism showed no significant relationship. Conclusion An outstanding fact that emerged in this study was that 94% of women with PCOS had HDL values <50 mg/dL. And 58% had triglycerides more than 150 mg/dL. Hence, lifestyle modification and early intervention will hopefully spare long-term complication of PCOS. How to cite this article Madusudhanan RR, Nambisan B, Brahmanandan M, Radha S. Study on the Prevalence and Characteristics of Metabolic Syndrome in Women of Reproductive Age Group with Polycystic Ovarian Syndrome. J South Asian Feder Obst Gynae 2017;9(4):341-347.

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