Severe depletion of peripheral blood dendritic cell subsets in obstructive sleep apnea patients: A new link with cancer?

Cytokine ◽  
2020 ◽  
Vol 125 ◽  
pp. 154831 ◽  
Author(s):  
Domenico Galati ◽  
Serena Zanotta ◽  
Angelo Canora ◽  
Giorgio E. Polistina ◽  
Carmine Nicoletta ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Dendritic Cell ◽  
Peripheral Blood ◽  
Obstructive Sleep ◽  
Dendritic Cell Subsets ◽  
Blood Dendritic Cell

“The Effect of Obstructive Sleep Apnea on Peripheral Blood Amino Acid and Biogenic Amine Metabolome at Multiple Time Points Overnight“

2020 ◽  
Author(s):  
Ott Kiens ◽  
Egon Taalberg ◽  
Viktoria Ivanova ◽  
Ketlin Veeväli ◽  
Triin Laurits ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Amino Acid ◽  
Sleep Apnea ◽  
Biogenic Amines ◽  
Peripheral Blood ◽  
Apnea Hypopnea Index ◽  
Multiple Time ◽  
Blood Concentrations ◽  
Time Points ◽  
Obstructive Sleep

Abstract There are no clinical studies that have investigated the differences in blood serum metabolome between obstructive sleep apnea (OSA) patients and controls. In a single-center prospective observational study, we compared metabolomic profiles in the peripheral blood of OSA patients with apnea-hypopnea index (AHI) > 15/h and control individuals. Blood was obtained at 3 different time points overnight: 21:00 p.m.; 5:00 a.m. and 7:00 a.m. We used a targeted approach for detecting amino acids and biogenic amines and analyzed the data with ranked general linear model for repeated measures. We recruited 31 patients with moderate-to-severe OSA and 32 controls. Significant elevations in median concentrations of alanine, proline and kynurenine in OSA patients compared to controls were detected. Significant changes in the overnight dynamics of peripheral blood concentrations occurred in OSA: glutamine, serine, threonine, tryptophan, kynurenine and glycine levels increased, whereas a fall occurred in the same biomarker levels in controls. Phenylalanine and proline levels decreased slightly, compared to a steeper fall in controls. The study indicates that serum profiles of amino acid and biogenic amines are significantly altered in patients with OSA referring to vast pathophysiologic shifts reflected in the systemic metabolism.

Peripheral blood lymphocyte repertoire in non-obese patients with Obstructive Sleep Apnea.

2018 ◽  
Author(s):  
Agata Raniszewska ◽  
Malgorzata Barnas ◽  
Piotr Bielicki ◽  
Iwona Kwiecien ◽  
Tomasz Skirecki ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Obese Patients ◽  
Obstructive Sleep

scholarly journals Altered distribution of peripheral blood dendritic cell subsets in patients with pulmonary paracoccidioidomycosis

Acta Tropica ◽  
2017 ◽  
Vol 173 ◽  
pp. 185-190 ◽  
Author(s):  
James Venturini ◽  
Ricardo Souza Cavalcante ◽  
Daniela Vanessa Moris ◽  
Márjorie de Assis Golim ◽  
Adriele Dandara Levorato ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Peripheral Blood ◽  
Dendritic Cell Subsets ◽  
Blood Dendritic Cell

scholarly journals Reactive Oxygen Species Production in Peripheral Blood Neutrophils of Obstructive Sleep Apnea Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Guoda Pilkauskaite ◽  
Skaidrius Miliauskas ◽  
Raimundas Sakalauskas
Keyword(s):  
Reactive Oxygen Species ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Peripheral Blood ◽  
Reactive Oxygen ◽  
Apnea Hypopnea Index ◽  
Ros Production ◽  
Oxygen Species ◽  
Obstructive Sleep ◽  
Blood Neutrophils

Obstructive sleep apnea (OSA) as well as obesity is associated with increased production of reactive oxygen species (ROS). Neutrophils produce great amounts of ROS. The aim was to evaluate peripheral blood neutrophils ROS production in men with OSA and to establish relations with disease severity and obesity.Methods. Forty-six men with OSA and 10 controls were investigated. OSA was confirmed by polysomnography (PSG), when apnea/hypopnea index was >5/h. Body mass index (BMI) was evaluated. Neutrophils were isolated from peripheral blood in the morning after PSG. Dihydrorhodamine-123 was used for ROS detection. Data is presented as median (25th and 75th percentiles). All subjects were divided into four groups: nonobese mild-to-moderate OSA, obese mild-to-moderate OSA, nonobese severe OSA, and obese severe OSA.Results. Neutrophil ROS production was higher in nonobese severe OSA group compared to nonobese mild-to-moderate OSA (mean fluorescence intensity (MFI) 213.4 (89.0–238.9) versus 44.5 (20.5–58.4),P<0.05). In obese patient groups, ROS production was more increased in severe OSA compared to mild-to-moderate OSA group (MFI 74.5 (47.9–182.4) versus 31.0 (14.8–53.8),P<0.05). It did not differ in the groups with different BMI and the same severity of OSA.Conclusion. Increased neutrophil ROS production was related to more severe OSA but not obesity.

scholarly journals Transcriptional survey of peripheral blood links lower oxygen saturation during sleep with reduced expressions of CD1D and RAB20 that is reversed by CPAP therapy

2019 ◽  
Author(s):  
Tamar Sofer ◽  
Ruitong Li ◽  
Roby Joehanes ◽  
Honghuang Lin ◽  
Adam C. Gower ◽  
...  
Keyword(s):  
Gene Expression ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Oxygen Saturation ◽  
Peripheral Blood ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Oxyhemoglobin Saturation ◽  
Obstructive Sleep

AbstractSleep Disordered Breathing (SDB) is associated with a wide range of physiological changes due, in part, to the influence of hypoxemia during sleep. We studied gene expression in peripheral blood mononuclear cells in association with three measures of SDB: Apnea Hypopnea Index (AHI); average oxyhemoglobin saturation (avgO2) during sleep; and minimum oxyhemoglobin saturation (minO2) during sleep. We performed discovery association analysis in two community-based studies, the Framingham Offspring Study (FOS; N=571) and the Multi-Ethnic Study of Atherosclerosis (MESA; N = 580). An association with false discovery rate (FDR) q < 0.05 in one study was considered “replicated” if a p < 0.05 was observed in the other study. Those genes that replicated across MESA and FOS, or with FDR q < 0.05 in meta-analysis, were used for analysis of gene expression in the blood of 15 participants from the Heart Biomarkers In Apnea Treatment (HeartBEAT) trial. HeartBEAT participants had moderate or severe obstructive sleep apnea (OSA) and were studied pre- and post-treatment (three months) with continuous positive airway pressure (CPAP). We also performed Gene Set Enrichment Analysis (GSEA) on all traits and cohort analyses. Twenty-two genes were associated with SDB traits in both MESA and FOS. Of these, lower expression of CD1D and RAB20 was associated with lower avgO2 in MESA and FOS. CPAP treatment increased the expression of these genes in HeartBEAT participants. Immunity and inflammation pathways were up-regulated in subjects with lower avgO2; i.e., in those with a more severe SDB phenotype (MESA), whereas immuno-inflammatory processes were down-regulated in response to CPAP treatment (HeartBEAT).One Sentence SummaryWe studied the association of gene expression in blood with obstructive sleep apnea traits, including oxygen saturation during sleep, and identified mechanisms that are reversed by treatment with Continuous Positive Airway Pressure.

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