Attenuated early pregnancy weight gain by prenatal lifestyle interventions does not prevent gestational diabetes in the LIFE-Moms consortium

ABSTRACT Objectives To study the association between excessive early pregnancy weight gain and risk of gestational diabetes mellitus (GDM). Materials and methods Study design-prospective observational study done at ESIC Medical College & PGIMSR, Chennai during the period November 2013 to May 2015. A total of 250 women who attended antenatal outpatient department at ESI Hospital Chennai were recruited for the study. Height and weight of the pregnant women was recorded during their first visit (up to 6 weeks) and at 14 weeks of gestation. Body mass index (BMI) was calculated according to Quetelet index. Waist hip ratio was measured at 6 weeks. The early gestation weight gain more than 2 kg was considered as excessive weight gain and was associated to the risk of developing GDM. Blood sugar was estimated using Diabetes in Pregnancy Study Group Index (DIPSI) standards. Results Of the 250 women studied, 104 women developed GDM. Excessive weight gain in the 1st trimester of pregnancy was significantly associated with the development of GDM with a p-value of 0.000. The other risk factors studied were BMI (p = 0.0064), waist/hip ratio (p = 0.0015), family history of diabetes mellitus (DM) (p = 0.00), which also had a significant association. Clinical significance This study shows that excessive weight gain in 1st trimester had an increased risk of GDM. The benefit of early identification of excess gestational weight gain would be the opportunity for intervention early in pregnancy to ideally decrease GDM. Conclusion Excessive early pregnancy weight gain, primarily in the 1st trimester may increase the risk of developing GDM. Thus, preventing excessive early pregnancy weight gain in the 1st trimester can be modified by lifestyle changes and simple exercise, which is a costless intervention, and can also decrease maternal and neonatal morbidity effectively. How to cite this article Menon M, Vasantha K. Excessive Early Pregnancy Weight Gain and Risk of Gestational Diabetes Mellitus. J South Asian Feder Obst Gynae 2016;8(3):189-192.

Download Full-text

Diagnostic accuracy of modified Hadlock formula for fetal macrosomia in women with gestational diabetes and pregnancy weight gain above recommended

Journal of Perinatal Medicine ◽

10.1515/jpm-2021-0013 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Boris Lovrić ◽

Siniša Šijanović ◽

Joško Lešin ◽

Josip Juras

Keyword(s):

Weight Gain ◽

Gestational Diabetes ◽

Diagnostic Accuracy ◽

Area Under The Curve ◽

Fetal Weight ◽

Pregnancy Weight Gain ◽

Singleton Pregnancy ◽

Time Period ◽

Modified Formula ◽

Pregnancy Weight

Abstract Objectives Women with gestational diabetes (GDM) and weight gain during pregnancy above recommended more often give birth to macrosomic children. The goal of this study was to evaluate the diagnostic accuracy of the modified formula for ultrasound assessment of fetal weight created in a pilot study using a similar specimen in comparison to the Hadlock-2 formula. Methods This is a prospective, cohort, applicative, observational, quantitative, and analytical study, which included 213 pregnant women with a singleton pregnancy, GDM, and pregnancy weight gain above recommended. Participants were consecutively followed in the time period between July 1st, 2016, and August 31st, 2020. Ultrasound estimations were made within three days before the delivery. Fetal weights estimated using both formulas were compared to the newborns’ weights. Results A total of 133 fetal weight estimations were made. In comparison to the newborns’ weight modified formula had significantly smaller deviation in weight estimation compared to the Hadlock-2 formula, higher frequency of deviation within 5% of newborns weights (78.2% [95% CI=0.74–0.83] vs. 60.2%), smaller frequency of deviations from 5 to 10% (19.5 vs. 33.8%) and above 10%, which was even more significant among macrosomic children. There were 36/50 (72%) correctly diagnosed cases of macrosomia by modified and 33/50 (66%) by Hadlock-2 formula. Area under the curve (AUC) for the modified formula was 0.854 (95% CI=0.776–0.932), and for the Hadlock-2 formula 0.824 (95% CI=0.740–0.908). The positive predictive value of the modified formula was 81.81%, the negative 97.91%. Conclusions In cases of greater fetal weights, the modified formula showed greater precision.

Download Full-text

Early Pregnancy Weight Gain Exerts the Strongest Effect on Birth Weight, Posing a Critical Time to Prevent Childhood Obesity

Obesity ◽

10.1002/oby.21878 ◽

2017 ◽

Vol 25 (9) ◽

pp. 1569-1576 ◽

Cited By ~ 16

Author(s):

Nicholas T. Broskey ◽

Peng Wang ◽

Nan Li ◽

Junhong Leng ◽

Weiqin Li ◽

...

Keyword(s):

Weight Gain ◽

Birth Weight ◽

Childhood Obesity ◽

Early Pregnancy ◽

Critical Time ◽

Pregnancy Weight Gain ◽

Pregnancy Weight

Download Full-text

Early-pregnancy weight gain and the risk of preeclampsia: A case-cohort study

Pregnancy Hypertension ◽

10.1016/j.preghy.2018.10.005 ◽

2018 ◽

Vol 14 ◽

pp. 205-212 ◽

Cited By ~ 1

Author(s):

Lisa M. Bodnar ◽

Katherine P. Himes ◽

Barbara Abrams ◽

Sara M. Parisi ◽

Jennifer A. Hutcheon

Keyword(s):

Cohort Study ◽

Weight Gain ◽

Early Pregnancy ◽

Pregnancy Weight Gain ◽

Pregnancy Weight ◽

Risk Of Preeclampsia

Download Full-text

Management of postprandial hyperglycaemia and weight gain in women with gestational diabetes mellitus using a novel telemonitoring system

Journal of International Medical Research ◽

10.1177/0300060518809872 ◽

2018 ◽

Vol 47 (2) ◽

pp. 754-764 ◽

Cited By ~ 3

Author(s):

Ebtisam A. Al-ofi ◽

Hala H. Mosli ◽

Kholoud A. Ghamri ◽

Sarah M. Ghazali

Keyword(s):

Diabetes Mellitus ◽

Weight Gain ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Dietary Advice ◽

Control Group ◽

Close Monitoring ◽

Pregnancy Weight Gain ◽

Glucose Levels ◽

Pregnancy Weight

Objectives The purpose of this study was to investigate the effect of remotely delivered telemedicine dietary advice on monitoring of blood glucose levels and weight gain of women with gestational diabetes mellitus (GDM). Methods Women with GDM were recruited and randomly allocated into two groups: a Tele-GDM group that received a telemonitoring device, and a control group that was followed-up traditionally. A telemonitoring service calculated the ratio of reaching or exceeding the pregnancy weight gain target (according to pre-pregnancy weight), following Institute of Medicine guidelines for healthy pregnancy weight gain. Results The sample comprised 27 women in the Tele-GDM group and 30 in the control group. At the end of pregnancy, the Tele-GDM group showed significantly lower 2-hour postprandial glucose levels than the control group. Most women in the Tele-GDM group reached their recommended range of weight gain at the end of pregnancy. Additionally, the Tele-GDM group showed significantly lower weight gain than the control group. Conclusions Telemonitoring can facilitate close monitoring of women with GDM and motivate patients to adopt a healthy lifestyle.

Download Full-text

1215: The impact of early pregnancy weight gain on ultrasound growth parameters and birth weight category

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2019.11.1227 ◽

2020 ◽

Vol 222 (1) ◽

pp. S747-S748

Author(s):

Christina Scifres ◽

William A. Grobman ◽

Hyagriv Simhan ◽

Uma M. Reddy ◽

Brian M. Mercer ◽

...

Keyword(s):

Weight Gain ◽

Birth Weight ◽

Early Pregnancy ◽

Growth Parameters ◽

Pregnancy Weight Gain ◽

Weight Category ◽

Pregnancy Weight ◽

The Impact

Download Full-text

Does Pregnancy Weight Gain Increase the Risk of Metformin Failure in the Treatment of Gestational Diabetes? [35D]

Obstetrics and Gynecology ◽

10.1097/01.aog.0000533014.92643.df ◽

2018 ◽

Vol 131 ◽

pp. 50S

Author(s):

Malini D. Persad ◽

Jennie Ou ◽

James Bernasko ◽

David Garry ◽

Diana Garretto ◽

...

Keyword(s):

Weight Gain ◽

Gestational Diabetes ◽

Pregnancy Weight Gain ◽

Pregnancy Weight

Download Full-text

The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth

Journal of Diabetes Research ◽

10.1155/2015/847674 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 4

Author(s):

Erin Graves ◽

David J. Hill ◽

Susan Evers ◽

Kristine Van Aarsen ◽

Brie Yama ◽

...

Keyword(s):

Weight Gain ◽

Gestational Diabetes ◽

Glucose Tolerance ◽

Blood Sugar ◽

Abnormal Glucose Tolerance ◽

Pregnancy Weight Gain ◽

Additive Interaction ◽

High Blood Sugar ◽

Antidepressant Use ◽

Pregnancy Weight

Objective. Factors linked with insulin resistance were examined for their association with large-for-gestational-age (LGA) infant birth weight and gestational diabetes.Study Design. Data came from a longitudinal cohort study of 2,305 subjects without overt diabetes, analyzed using multinomial logistic and linear regression.Results. High maternal BMI (OR=1.53(1.11, 2.12)), height (1.98 (1.62, 2.42)), antidepressant use (1.71 (1.20, 2.44)), pregnancy weight-gain exceeding 40 pounds (1.79 (1.25, 2.57)), and high blood sugar (2.68, (1.53, 5.27)) were all positively associated with LGA birth. Strikingly, the difference in risk from diagnosed and treated gestational diabetes compared to women with a single abnormal glucose tolerance test (but no diagnosis of gestational diabetes) was significant (OR=0.65,p=0.12versusOR=2.84,p<0.01). When weight/length ratio was used instead, different factors were found to be significant. BMI and pregnancy weight-gain were found to influence the development of gestational diabetes, through an additive interaction.Conclusions. High prepregnancy BM, height, antidepressant use, pregnancy weight-gain exceeding 40 pounds, and high blood sugar were associated with LGA birth, but not necessarily infant weight/length ratio. An additive interaction between BMI and pregnancy weight-gain influenced gestational diabetes development.

Download Full-text