Fasting plasma glucose and glucose fluctuation are associated with COVID-19 prognosis regardless of pre-existing diabetes

<a>OBJECTIVE: </a>Acrylamide exposure from daily-consumed food has raised global concern. We aimed to assess the exposure-response relationships of internal acrylamide exposure with oxidative DNA damage, lipid peroxidation and fasting plasma glucose (FPG) alteration, and investigate the mediating role of oxidative DNA damage and lipid peroxidation in the association of internal acrylamide exposure with FPG. RESEARCH DESIGN AND METHODS: FPG and urinary biomarkers of oxidative DNA damage (8-hydroxy-deoxy-guanosine, 8-OHdG), lipid peroxidation (8-iso-prostaglandin-F2α, 8-iso-PGF2α) and acrylamide exposure (N-acetyl-S-(2-carbamoylethyl)-L-cysteine, AAMA; N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine, GAMA) were measured for 3,270 general adults from the Wuhan-Zhuhai cohort. The associations of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α and FPG were assessed by linear mixed models. The mediating roles of 8-OHdG and 8-iso-PGF2α were evaluated by mediation analysis. RESULTS: We found significant linear positive dose-response relationships of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α and FPG (except GAMA with FPG), and 8-iso-PGF2α with FPG. Each 1-unit increase in log-transformed level of AAMA, ΣUAAM (AAMA+GAMA) or 8-iso-PGF2α was associated with a 0.17-, 0.15- or 0.23-mmol/L increase in FPG, respectively (P or/and P trend<0.05). Each 1% increase in AAMA, GAMA or ΣUAAM was associated with a 0.19%, 0.27% or 0.22% increase in 8-OHdG, respectively, and a 0.40%, 0.48% or 0.44% increase in 8-iso-PGF2α, respectively (P and P trend<0.05). Increased 8-iso-PGF2α rather than 8-OHdG significantly mediated 64.29% and 76.92% of the AAMA and ΣUAAM associated-FPG increases, respectively. CONCLUSIONS: Exposure of general adult population to acrylamide was associated with FPG elevation, oxidative DNA damage and lipid peroxidation, which in turn partly mediated acrylamide-associated FPG elevation.

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Fasting Plasma Glucose Concentration in Relation to Nutritional Status Indicator and Physical Activity Level among Schizophrenia Patient

World Nutrition Journal ◽

10.25220/wnj/v02.i1.0001 ◽

2018 ◽

Vol 2 (1) ◽

pp. 1

Author(s):

Della MW Cintakaweni ◽

Saptawati Bardosono ◽

Hervita Diatri

Keyword(s):

Physical Activity ◽

Nutritional Status ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Schizophrenia Patient ◽

Activity Level ◽

Plasma Glucose Concentration ◽

Fasting Plasma ◽

Status Indicator ◽

Fasting Plasma Glucose Concentration

Diabetes mellitus is often accompanied to schizophrenia patient. This condition probably related to genetic, antipsychotic drugs and the development of schizophrenia that can lead to an unhealthy lifestyle, such as sedentary lifestyle and the increased of dietary intake. Cross-sectional study was held in Psychiatry Department Cipto Mangunkusumo Hospital during May to June 2014 to determine the correlation between fasting plasma glucose concentration in schizophrenia patient to their nutritional status indicator and physical activity level. Forty-seven subjects finished the study protocol. The result showed that the fasting plasma glucose concentration in schizophrenia patient has no correlation with nutritional status indicator and physical activity level, in which 91.5% subject had normal fasting plasma glucose. However, there is a need for further investigation because 31.9% subject was overweight, 48.9% subject was obesity and 74.5% subject had central obesity.

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