Antimicrobial activity of tigecycline and cefoperazone/sulbactam tested against 18,386 Gram-negative organisms from Europe and the Asia-Pacific region (2013–2014)

2017 ◽  
Vol 88 (2) ◽  
pp. 177-183 ◽  
Author(s):  
M.A. Pfaller ◽  
R.K. Flamm ◽  
L.R. Duncan ◽  
R.E. Mendes ◽  
R.N. Jones ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Asia Pacific ◽  
Pacific Region ◽  
Asia Pacific Region ◽  
Gram Negative ◽  
Gram Negative Organisms

scholarly journals Emergence of High Levels of Extended-Spectrum-β-Lactamase-Producing Gram-Negative Bacilli in the Asia-Pacific Region: Data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) Program, 2007

2009 ◽  
Vol 53 (8) ◽  
pp. 3280-3284 ◽  
Author(s):  
Stephen P. Hawser ◽  
Samuel K. Bouchillon ◽  
Daryl J. Hoban ◽  
Robert E. Badal ◽  
Po-Ren Hsueh ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Klebsiella Oxytoca ◽  
Asia Pacific ◽  
Pacific Region ◽  
Asia Pacific Region ◽  
Gram Negative ◽  
E Coli ◽  
Extended Spectrum ◽  
Region Data ◽  
Abdominal Infections

ABSTRACT Of 3,004 gram-negative bacilli collected from intra-abdominal infections in the Asia-Pacific region during 2007, 42.2% and 35.8% of Escherichia coli and Klebsiella spp., respectively, were extended-spectrum β-lactamase (ESBL) positive. Moreover ESBL rates in India for E. coli, Klebsiella pneumoniae, and Klebsiella oxytoca were 79.0%, 69.4%, and 100%, respectively. ESBL-positive E. coli rates were also relatively high in China (55.0%) and Thailand (50.8%). Ertapenem and imipenem were the most active drugs tested, inhibiting over 90% of all species, including ESBL-positive isolates with the exception of Pseudomonas aeruginosa isolates (<90% susceptible to all study drugs) and ESBL-positive Klebsiella pneumoniae isolates (<90% susceptible to all study drugs except imipenem). Quinolones achieved 90% inhibition levels only against ESBL-negative K. pneumoniae and ESBL-negative K. oxytoca. A decline in ampicillin-sulbactam activity was noted, with only 34.5% of all Enterobacteriaceae inhibited in this study.

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