Histological renal damage and eligibility for kidney donation are worse in patients with biopsy-proven non-alcoholic steatohepatitis compared with simple steatosis

2020 ◽  
Vol 52 ◽  
pp. e39
Author(s):  
L. Mulazzani ◽  
D. Capelli ◽  
M. Labanti ◽  
C. Zanfi ◽  
G. Sangiorgi ◽  
...  
Keyword(s):  
Renal Damage ◽  
Kidney Donation ◽  
Simple Steatosis ◽  
Alcoholic Steatohepatitis

Histological renal damage and eligibility for kidney donation are worse in patients with biopsy-proven non-alcoholic steatohepatitis compared with simple steatosis

2020 ◽  
Vol 73 ◽  
pp. S156
Author(s):  
Lorenzo Mulazzani ◽  
Davide Capelli ◽  
Manuel Labanti ◽  
Chiara Zanfi ◽  
Gabriela Sangiorgi ◽  
...  
Keyword(s):  
Renal Damage ◽  
Kidney Donation ◽  
Simple Steatosis ◽  
Alcoholic Steatohepatitis

scholarly journals Dietary Patterns in Patients With Different Forms of Non-alcoholic Fatty Liver Disease

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 450-450
Author(s):  
Armida Sasunova ◽  
Sergey Morozov ◽  
Vasily Isakov
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Dietary Patterns ◽  
Fatty Liver Disease ◽  
Healthy Eating Index ◽  
Alcoholic Fatty Liver ◽  
Simple Steatosis ◽  
Alcoholic Steatohepatitis ◽  
Nash Group ◽  
Alcoholic Fatty Liver Disease

Abstract Objectives The aim of the study was to compare food patterns in patients with simple steatosis (SS) and non-alcoholic steatohepatitis (NASH). Methods Prospective study was approved by LEC and enrolled subjects with confirmed non-alcoholic fatty liver disease (SS or NASH group). Nutrilogic software (Nutrilogic, Russia) was used for diet assessment. Dietary patterns were assessed according to the Healthy Eating Index (HEI): amounts of the major groups of foods and food products (grains, fruits, vegetables, dairy products, meats, fats and confectioneries) consumption were compared to the levels described in the HEI, and individual deviation rates were obtained. Nonparametric statistics (Mann-Whitney U test) was used to compare deviation rates found in subjects of SS and NASH groups. Results Subjects in NASH group (n = 22) were younger (Mean ± SD: 48.6 ± 13.4 y.o.) than those in SS group (n = 156; 56.5 ± 12.3 y.o., P = 0.008). Main macronutrients consumption did not differ between the groups. Although dietary patterns of major groups of foods consumption did not differ between SS and NASH groups, analysis of the foods subgroups revealed dissimilarity in the structure of vegetables and fats consumption. Patients with NASH consumed larger amounts of potatoes (0.14 ± 0.08 vs 0.11 ± 0.15, P = 0.006), and lower – of onions (0.02 ± 0.03 vs 0.07 ± 0.1, P = 0.006); they also consumed lower amounts of dairy butter (0.14 ± 0.44 vs 0.15 ± 0.21, P = 0.009) compared to subjects with simple steatosis. No other difference in the structure of vegetables (beans, root crops, leafy and other vegetables), fats (animal fats, vegetable oils, margarines) and other major groups of foods consumption was revealed. Conclusions Dietary patterns of patients with non-alcoholic steatohepatitis and simple steatosis differ. The obtained results may help in diet modification in patients with NAFLD in case of confirmation in larger multicenter trials. Funding Sources Russian Science Foundation, grant #1976-30014.

scholarly journals Use of non-invasive serum glycan markers to distinguish non-alcoholic steatohepatitis from simple steatosis

2015 ◽  
Vol 30 (3) ◽  
pp. 528-534 ◽  
Author(s):  
Yasushi Yamasaki ◽  
Kazuhiro Nouso ◽  
Koji Miyahara ◽  
Nozomu Wada ◽  
Chihiro Dohi ◽  
...  
Keyword(s):  
Simple Steatosis ◽  
Non Invasive ◽  
Alcoholic Steatohepatitis

Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis

2006 ◽  
Vol 111 (2) ◽  
pp. 135-143 ◽  
Author(s):  
Piero Portincasa ◽  
Ignazio Grattagliano ◽  
Bernhard H. Lauterburg ◽  
Vincenzo O. Palmieri ◽  
Giuseppe Palasciano ◽  
...  
Keyword(s):  
Body Size ◽  
Stable Isotope ◽  
Predictive Value ◽  
Breath Tests ◽  
Alcoholic Fatty Liver ◽  
Simple Steatosis ◽  
Non Invasive ◽  
Alcoholic Steatohepatitis ◽  
Metabolic Functions ◽  
Mitochondrial Functions

Effectively assessing subtle hepatic metabolic functions by novel non-invasive tests might be of clinical utility in scoring NAFLD (non-alcoholic fatty liver disease) and in identifying altered metabolic pathways. The present study was conducted on 39 (20 lean and 19 obese) hypertransaminasemic patients with histologically proven NAFLD {ranging from simple steatosis to severe steatohepatitis [NASH (non-alcoholic steatohepatitis)] and fibrosis} and 28 (20 lean and eight overweight) healthy controls, who underwent stable isotope breath testing ([13C]methacetin and [13C]ketoisocaproate) for microsomal and mitochondrial liver function in relation to histology, serum hyaluronate, as a marker of liver fibrosis, and body size. Compared with healthy subjects and patients with simple steatosis, NASH patients had enhanced methacetin demethylation (P=0.001), but decreased (P=0.001) and delayed (P=0.006) ketoisocaproate decarboxylation, which was inversely related (P=0.001) to the degree of histological fibrosis (r=−0.701), serum hyaluronate (r=−0.644) and body size (r=−0.485). Ketoisocaproate decarboxylation was impaired further in obese patients with NASH, but not in patients with simple steatosis and in overweight controls. NASH and insulin resistance were independently associated with an abnormal ketoisocaproate breath test (P=0.001). The cut-off value of 9.6% cumulative expired 13CO2 for ketoisocaproate at 60 min was associated with the highest prediction (positive predictive value, 0.90; negative predictive value, 0.73) for NASH, yielding an overall sensitivity of 68% and specificity of 94%. In conclusion, both microsomal and mitochondrial functions are disturbed in NASH. Therefore stable isotope breath tests may usefully contribute to a better and non-invasive characterization of patients with NAFLD.

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