Changes in the clinical phenotype and behavior of pediatric luminal Crohn's disease at diagnosis in the last decade

2021 ◽  
Author(s):  
Samuel Sassine ◽  
Mathieu Savoie Robichaud ◽  
Yi Fan Lin ◽  
Lisa Djani ◽  
Christine Cambron-Asselin ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Phenotype ◽  
And Behavior

Autoantibodies to glycoprotein 2 are associated with the clinical phenotype in Crohn's disease

2014 ◽  
Vol 52 (08) ◽  
Author(s):  
D Roggenbuck ◽  
DP Bogdanos ◽  
D Reinhold ◽  
U von Arnim ◽  
P Malfertheiner ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Phenotype

scholarly journals Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Bruno Rafael Ramos de Mattos ◽  
Maellin Pereira Gracindo Garcia ◽  
Julia Bier Nogueira ◽  
Lisiery Negrini Paiatto ◽  
Cassia Galdino Albuquerque ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Severe Disease ◽  
Biological Therapies ◽  
Promising Alternative ◽  
Biological Treatments ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
And Behavior

Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal tract associated with an imbalance of the intestinal microbiota. Crohn’s disease (CD) and ulcerative colitis (UC) are the most widely known types of IBD and have been the focus of attention due to their increasing incidence. Recent studies have pointed out genes associated with IBD susceptibility that, together with environment factors, may contribute to the outcome of the disease. In ulcerative colitis, there are several therapies available, depending on the stage of the disease. Aminosalicylates, corticosteroids, and cyclosporine are used to treat mild, moderate, and severe disease, respectively. In Crohn’s disease, drug choices are dependent on both location and behavior of the disease. Nowadays, advances in treatments for IBD have included biological therapies, based mainly on monoclonal antibodies or fusion proteins, such as anti-TNF drugs. Notwithstanding the high cost involved, these biological therapies show a high index of remission, enabling a significant reduction in cases of surgery and hospitalization. Furthermore, migration inhibitors and new cytokine blockers are also a promising alternative for treating patients with IBD. In this review, an analysis of literature data on biological treatments for IBD is approached, with the main focus on therapies based on emerging recombinant biomolecules.

scholarly journals Correction: IDO1 and IDO2 Non-Synonymous Gene Variants: Correlation with Crohn's Disease Risk and Clinical Phenotype

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0133098
Author(s):  
Alexander Lee ◽  
Navya Kanuri ◽  
Yuanhao Zhang ◽  
Gregory S. Sayuk ◽  
Ellen Li ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Risk ◽  
Clinical Phenotype ◽  
Gene Variants

Clinical phenotype and gene expression profile in Crohn's disease

2007 ◽  
Vol 292 (1) ◽  
pp. G298-G304 ◽  
Author(s):  
Claudio Csillag ◽  
Ole Haagen Nielsen ◽  
Rehannah Borup ◽  
Finn Cilius Nielsen ◽  
Jørgen Olsen
Keyword(s):  
Gene Expression ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intracellular Transport ◽  
Clinical Phenotype ◽  
Expression Profiles ◽  
Expression Patterns ◽  
Principal Component ◽  
Gene Profiling ◽  
Gene Expression Patterns

The clinical course varies significantly among patients with Crohn's disease (CD). This study investigated whether gene expression profiles generated by DNA microarray technology might predict disease progression. Biopsies from the descending colon were obtained colonoscopically from 40 CD patients. Gene profiling analyses were performed using a Human Genome U133 Plus 2.0 GeneChip Array, and summarization into a single expression measure for each probe set was performed using the robust multiple array procedure. Principal component analysis demonstrated that three components explain two-thirds of the total variation. The most important parameters for the determination of the colonic gene expression patterns were the presence of disease (CD) and presence of inflammation. Superimposition of clinical phenotype data revealed a grouping of the samples from patients with stenosis toward negative values on the axis of the second principal component. The functional annotation analysis suggested that the expression of genes involved in intracellular transport and cytoskeletal organization might influence the development of stenosis. In conclusion, even though most variation in the colonic gene expression patterns is due to presence or absence of CD and inflammation status, the development of stenosis is a parameter that affects colonic gene expression to some extent.

Location and behavior of Crohn's disease according to Vienna classification evolution over the course of the disease

2001 ◽  
Vol 120 (5) ◽  
pp. A141
Author(s):  
Edouard J. Louis ◽  
Amaud Collard ◽  
Anne-Francoise Oger ◽  
Elodie De Groote ◽  
Jacques Belaiche
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vienna Classification ◽  
And Behavior

scholarly journals Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s Disease

2005 ◽  
Vol 19 (9) ◽  
pp. 575-578 ◽  
Author(s):  
Hugh J Freeman
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Phenotype ◽  
Stricture Formation ◽  
Extensive Disease ◽  
Vienna Classification ◽  
New Treatments ◽  
Extent Of Disease

Diffuse and extensive jejunoileal Crohn's disease is an uncommon entity. In 39 patients, including 21 males and 18 females, followed for a mean duration of over 16 years between 1979 and 2004, the extent of disease was defined and disease behaviour characterized. Over 80% of patients had concomitant colonic and/or gastroduodenal involvement with Crohn's disease, suggesting that this entity may represent a specific clinical phenotype of extensive disease localization. Classification of Crohn's disease behaviour using the Vienna classification schema revealed that virtually all patients in this study suffered from intestinal stricture formation or penetrating disease complications. Moreover, pharmacological therapies with corticosteroids and immunosuppressant drugs were rarely successful, with virtually all patients requiring at least one, and usually multiple, intestinal resections. Finally, most patients required long-term nutritional support, often with home parenteral nutrition. New treatments are required, possibly defined on the basis of their effectiveness in reducing the severity and extent of intestinal disease, rather than more conventional statistically driven reductions in disease activity indexes.

Autoimmunity in Crohn's Disease—A Putative Stratification Factor of the Clinical Phenotype

2016 ◽  
pp. 77-101 ◽  
Author(s):  
D. Roggenbuck ◽  
D. Reinhold ◽  
D.C. Baumgart ◽  
P. Schierack ◽  
K. Conrad ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Phenotype

scholarly journals IDO1 and IDO2 Non-Synonymous Gene Variants: Correlation with Crohn's Disease Risk and Clinical Phenotype

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115848 ◽  
Author(s):  
Alexander Lee ◽  
Navya Kanuri ◽  
Yuanhao Zhang ◽  
Gregory S. Sayuk ◽  
Ellen Li ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Risk ◽  
Clinical Phenotype ◽  
Gene Variants
Sign in / Sign up

Export Citation Format

Share Document