scholarly journals The association of alcohol intake with gamma-glutamyl transferase (GGT) levels: Evidence for correlated genetic effects

2014 ◽  
Vol 134 ◽  
pp. 99-105 ◽  
Author(s):  
Jenny H.D.A. van Beek ◽  
Marleen H.M. de Moor ◽  
Lot M. Geels ◽  
Michel R.T. Sinke ◽  
Eco J.C. de Geus ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Genetic Effects ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals Serum gamma-glutamyl transferase, a marker of alcohol intake, is associated with telomere length and cardiometabolic risk in young adulthood

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Esmée M. Bijnens ◽  
Catherine Derom ◽  
Evert Thiery ◽  
Dries S. Martens ◽  
Ruth J. F. Loos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alcohol Consumption ◽  
Telomere Length ◽  
Young Adulthood ◽  
Alcohol Intake ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

AbstractStudies based on self-reported alcohol consumption and telomere length show inconsistent results. Therefore, we studied the association between gamma-glutamyl transferase (GGT), a widely used biomarker of alcohol intake, and telomere length. The possible health relevance in young adulthood was explored by investigating cardiometabolic risk factors. Mixed modelling was performed to examine GGT and alcohol consumption in association with telomere length in buccal cells of 211 adults between 18 and 30 years old of the East Flanders Prospective Twin Survey. In addition, we investigated the association between GGT and cardiometabolic risk factors; waist circumference, systolic blood pressure, fasting glucose, HDL cholesterol, and triglycerides. Although we did not observe an association between self-reported alcohol consumption and telomere length, our results show that a doubling in serum GGT is associated with 7.80% (95% CI − 13.9 to − 1.2%; p = 0.02) shorter buccal telomeres, independently from sex, chronological age, educational level, zygosity and chorionicity, waist-to-hip ratio and smoking. The association between GGT was significant for all five cardiometabolic risk factors, while adjusting for age. We show that GGT, a widely used biomarker of alcohol consumption, is associated with telomere length and with risk factors of cardiometabolic syndrome, despite the young age of this study population.

Gamma-Glutamyl Transferase: A Useful Marker of Habitual Drinking in Cases of Alcohol-Associated Osteonecrosis of the Femoral Head

2020 ◽  
Author(s):  
Hidetoshi Hamada ◽  
Wataru Ando ◽  
Masaki Takao ◽  
Nobuhiko Sugano
Keyword(s):  
Femoral Head ◽  
Alcohol Intake ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Serum Levels ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Median Serum ◽  
Glutamyl Transferase ◽  
Epidemiological Information

Abstract Aims Alcohol intake is one of the factors associated with the occurrence of osteonecrosis of the femoral head (ONFH), and its epidemiological information regarding alcohol intake depends on patients’ self-reports. Therefore, we analysed the efficacy of laboratory tests as an objective diagnostic tool to indicate habitual drinking in patients with alcohol-associated ONFH. Methods This study included 109 consecutive patients diagnosed with ONFH who underwent primary hip surgery in our institution between 2010 and 2018. The patients were classified into group AL (alcohol-associated ONFH; n = 26) and group NO (alcohol-unassociated ONFH; n = 83), based on their self-reported information. Serum levels of gamma-glutamyl transferase (GGT), mean corpuscular volume (MCV), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol and triglycerides were compared between both groups. The sensitivities and specificities with the optimal cut-off values for detecting alcohol-associated ONFH were compared among these markers. Results The median serum levels of GGT, AST and ALT were significantly higher in the AL group than in the NO group. The receiver operating characteristic curve analysis demonstrated an area under the curve of 0.795 for GGT, 0.731 for AST and 0.709 for ALT. The optimal cut-off level of GGT as a marker for alcohol-associated ONFH was 36.5 units/L, with a sensitivity of 76% and specificity of 80%, and it was found to be the best marker among the other examined laboratory markers. Conclusion Serum GGT level is a useful laboratory marker with moderate accuracy that indicates habitual drinking in patients with alcohol-associated ONFH.

Prognostic value of gamma-glutamyl transferase in patients with diabetes mellitus and coronary artery disease

2016 ◽  
Vol 49 (15) ◽  
pp. 1127-1132 ◽  
Author(s):  
Gjin Ndrepepa ◽  
Roisin Colleran ◽  
Anke Luttert ◽  
Siegmund Braun ◽  
Salvatore Cassese ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Prognostic Value ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Patients With Diabetes ◽  
Artery Disease ◽  
Glutamyl Transferase

Bước đầu khảo sát sự ổn định của một số chỉ số xét nghiệm sinh hóa trong máu toàn phần và huyết tương theo thời gian bảo quản mẫu bệnh phẩm

2021 ◽  
Vol 16 (3) ◽  
Author(s):  
Đinh Thị Thảo ◽  
Trần Thái Hà ◽  
Nguyễn Viết Tân ◽  
Vi Thị Nhung ◽  
Nguyễn Cẩm Thạch
Keyword(s):  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Mau Mau ◽  
Glutamyl Transferase

Mục tiêu: Đánh giá ảnh hưởng của thời gian bảo quản đến kết quả phân tích các chỉ số urea, creatinine, triglycerid, cholesterol, HDL-cholesterol, LDL-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT), acid uric, bilirubin toàn phần, bilirubin trực tiếp trong mẫu máu toàn phần và huyết tương. Đối tượng và phương pháp: Gồm 162 mẫu máu toàn phần được chống đông bằng Li-heparin của 81 bệnh nhân (mỗi bệnh nhân lấy 2 ống mẫu) đến khám tại Khoa Khám bệnh - Bệnh viện Trung ương Quân đội 108 từ ngày 15/01/2021 đến ngày 15/02/2021. Với mỗi bệnh nhân: Ngay sau khi lấy máu, ống mẫu 1 được ly tâm, phân tích thường quy các chỉ số hóa sinh (phần còn lại sau phân tích gọi là mẫu 1), ống mẫu 2 được tách lấy huyết tương (mẫu 2). Sau đó, cả 2 mẫu được lưu trong tủ lạnh ở nhiệt độ 4oC. Sử dụng các mẫu này để phân tích các chỉ số hóa sinh tại các thời điểm 24, 48, và 72 giờ sau khi lấy máu. Kết quả: Nồng độ AST của các mẫu 1 được lưu trong 24, 48, 72 giờ cao hơn nồng độ AST phân tích thường quy (p<0,05). Nồng độ bilirubin toàn phần, bilirubin trực tiếp của mẫu 1 và mẫu 2 giảm dần theo thời gian lưu mẫu (p<0,05). Kết luận: Nồng độ các chỉ số AST, bilirubin toàn phần, bilirubin trực tiếp của các mẫu lưu (huyết tương và mẫu máu sau phân tích không loại bỏ các thành phần hữu hình) không ổn định theo thời gian bảo quản ở 4oC. Nồng độ các chỉ số urea, creatinine, triglycerid, cholesterol, HDL-cholesterol, LDL-cholesterol, ALT, GGT, acid uric (huyết tương và mẫu máu sau phân tích không loại bỏ các thành phần hữu hình) ổn định đến 72 giờ ở 4oC. Từ khóa: Hóa sinh, bảo quản bệnh phẩm, Bệnh viện Trung ương Quân đội 108.

P70 Gamma Glutamyl Transférase (GGT) et syndrome métabolique à la Réunion- Données issues de la cohorte REDIA 1

2008 ◽  
Vol 34 ◽  
pp. H63
Author(s):  
N. Le Moullec ◽  
A. Fianu ◽  
X. Debussche ◽  
C. Le Pommelet ◽  
M.C. Boyer ◽  
...  
Keyword(s):  
Syndrome Métabolique ◽  
Gamma Glutamyl Transferase ◽  
La Réunion ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

The diagnostic value of a hepatoma-specific band of serum gamma-glutamyl transferase

1985 ◽  
Vol 36 (6) ◽  
pp. 667-669 ◽  
Author(s):  
Ke-Cheng Xu ◽  
Xian-Yong Meng ◽  
Yi-Cai Shi ◽  
Zheng-Ju Ge ◽  
Ling Ye ◽  
...  
Keyword(s):  
Diagnostic Value ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Specific Band ◽  
Glutamyl Transferase

Gamma-Glutamyl Transferase: Applications in Forensic Pathology: I: Study of Blood Serum Recovered from Human Bodies

1987 ◽  
Vol 27 (3) ◽  
pp. 152-160 ◽  
Author(s):  
M. Piette ◽  
G. De Schrijver
Keyword(s):  
Body Fluid ◽  
Sampling Site ◽  
Chronic Alcoholism ◽  
Gamma Glutamyl Transferase ◽  
Post Mortem ◽  
Chronic Alcohol ◽  
Gamma Glutamyl ◽  
Liver Degeneration ◽  
Glutamyl Transferase

In order to appreciate more adequately chronic alcohol use by the deceased in the course of a medico-legal autopsy we studied the usefulness of a determination of gamma-glutamyl transferase (GGT) activity in cadaver serum. Some preliminary tests were performed to check the post-mortem stability of this enzyme, the influence of post-mortem haemolysis upon enzyme determination, the influence of the sampling site upon the enzyme activity and the suitability of vitreous humour as an alternative body fluid for GGT determination. Secondly, correlations between GGT activity and the degree of fatty liver degeneration and fibrosis (both possibly alcohol-induced tissue lesions) were searched for. Finally, a comparison was made between strictly selected groups of alcoholics and non-alcoholics. We concluded that, keeping in mind the necessary precautions to avoid typical post-mortem fallacies, a GGT determination in cadaver serum provides a useful parameter for detecting chronic alcoholism at the forensic autopsy.

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