Thyroid dysfunction prevalence and relation to glycemic control in patients with type 2 diabetes mellitus

2019 ◽  
Vol 13 (4) ◽  
pp. 2513-2517 ◽  
Author(s):  
Essmat Hassan Elgazar ◽  
Noha Elsayed Esheba ◽  
Safenaz Alsaeed Shalaby ◽  
Wael Farrag Mohamed
2021 ◽  
pp. 25-27
Author(s):  
Fouzia Sultana Shaik ◽  
G. Vijaya Kumar

Background: The relationship between normal thyroid function and type 2 diabetes has been a particular focus of concern. Type 2 Diabetes being the most common endocrine, metabolic disorder, there lies a curiosity to understand and learn the association of this disease with another common endocrine gland that is the thyroid gland. This study is aimed to describe the association of poorly controlled diabetes and thyroid dysfunction. OBJECTIVES: Ÿ To study the thyroid functions in patients with type 2 diabetes mellitus. Ÿ To study the spectrum of thyroid dysfunction in patients with type 2 diabetes mellitus. Materials And Methods: A hospital-based observational prospective study was conducted in the Santhiram Medical College and General Hospital for six months. Patients with type 2 diabetes mellitus of age more than 30 years, from OPD and IPD of all the departments in Santhiram General Hospital irrespective of glucose control and treatment, with informed written consent were studied. Thyroid prole tests, target organ evaluation for type 2 diabetes mellitus were performed for all patients in this study group. Thyroid USG was done. Results: 100 cases of type 2 diabetes mellitus without proven thyroid disease were included in the study . Thyroid disorders were diagnosed in 29 % cases . Hypothyroidism in 1 , hyperthyroidism in 13 and subclinical hypothyroidism in 15 cases. In this study 50 patients were male, 50 were females. Females ( 36%) had high incidence of thyroid disorder than males ( 22%). Subclinical hypothyroidism was more common (31.25%) in elderly age group. Elderly females had high incidence of subclinical hypothyroidism (18.2%). Clinical features of hyperthyroidism are seen in 8 patients. In the patients with hyperthyroidism( 55.5%) there was poor glycemic control . Duration of diabetes has no relation with incidence of thyroid disorders. Majority of patients with subclinical hypothyroidism had uncontrolled sugars with microvascular complications. Conclusion: Prevalence of thyroid disorders in diabetes mellitus is 29%. Incidence is higher in elderly population . Duration of diabetes mellitus has no impact on thyroid dysfunction. Severe diabetic complications are noted in patients with subclinical hypothyroidism. Subclinical hypothyroidism is seen commonly among females. Diabetes with hyperthyroidism has poor glycemic control


Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 137-LB ◽  
Author(s):  
NEHA KARAJGIKAR ◽  
KARLA B. DETOYA ◽  
JANICE N. BEATTIE ◽  
STACEY J. LUTZ-MCCAIN ◽  
MONIQUE Y. BOUDREAUX-KELLY ◽  
...  

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 90-LB
Author(s):  
SANJAY K. BAJPAI ◽  
RADHIKA NAIR ◽  
TICH CHANGAMIRE ◽  
RICHARD SHEER ◽  
QIANQIAN WANG ◽  
...  

2017 ◽  
Vol 5 (1) ◽  
pp. e000431 ◽  
Author(s):  
Martin Fried ◽  
Karin Dolezalova ◽  
Adam P Chambers ◽  
Elliott J Fegelman ◽  
Robin Scamuffa ◽  
...  

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Xiaowen Zhang ◽  
Jie Sun ◽  
Wenqing Han ◽  
Yaqiu Jiang ◽  
Shiqiao Peng ◽  
...  

Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM patients as marked by the HbA1C levels.Design and Methods.The terms “rs225014,” “thr92ala,” “T92A,” or “dio2 a/g” were used to search for eligible studies in the PubMed, Embase, and Cochrane databases and Google Scholar. A systematic review and meta-analysis of studies including both polymorphism testing and glycated hemoglobin (HbA1C) assays were performed.Results. Four studies were selected, totaling 2190 subjects. The pooled mean difference of the studies was 0.48% (95% CI, 0.18–0.77%), indicating that type 2 diabetics homozygous for the Dio2 Thr92Ala polymorphism had higher HbA1C levels.Conclusions. Homozygosity for the Dio2 Thr92Ala polymorphism is associated with higher HbA1C levels in T2DM patients. To confirm this conclusion, more studies of larger populations are needed.


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