TO STUDY THE PREVALENCE OF THYROID DYSFUNCTION AND IT'S EFFECTS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN TERTIARY CARE HOSPITAL

Glycemic Control ◽

General Hospital ◽

Thyroid Dysfunction ◽

Thyroid Disorders ◽

High Incidence

Background: The relationship between normal thyroid function and type 2 diabetes has been a particular focus of concern. Type 2 Diabetes being the most common endocrine, metabolic disorder, there lies a curiosity to understand and learn the association of this disease with another common endocrine gland that is the thyroid gland. This study is aimed to describe the association of poorly controlled diabetes and thyroid dysfunction. OBJECTIVES: Ÿ To study the thyroid functions in patients with type 2 diabetes mellitus. Ÿ To study the spectrum of thyroid dysfunction in patients with type 2 diabetes mellitus. Materials And Methods: A hospital-based observational prospective study was conducted in the Santhiram Medical College and General Hospital for six months. Patients with type 2 diabetes mellitus of age more than 30 years, from OPD and IPD of all the departments in Santhiram General Hospital irrespective of glucose control and treatment, with informed written consent were studied. Thyroid prole tests, target organ evaluation for type 2 diabetes mellitus were performed for all patients in this study group. Thyroid USG was done. Results: 100 cases of type 2 diabetes mellitus without proven thyroid disease were included in the study . Thyroid disorders were diagnosed in 29 % cases . Hypothyroidism in 1 , hyperthyroidism in 13 and subclinical hypothyroidism in 15 cases. In this study 50 patients were male, 50 were females. Females ( 36%) had high incidence of thyroid disorder than males ( 22%). Subclinical hypothyroidism was more common (31.25%) in elderly age group. Elderly females had high incidence of subclinical hypothyroidism (18.2%). Clinical features of hyperthyroidism are seen in 8 patients. In the patients with hyperthyroidism( 55.5%) there was poor glycemic control . Duration of diabetes has no relation with incidence of thyroid disorders. Majority of patients with subclinical hypothyroidism had uncontrolled sugars with microvascular complications. Conclusion: Prevalence of thyroid disorders in diabetes mellitus is 29%. Incidence is higher in elderly population . Duration of diabetes mellitus has no impact on thyroid dysfunction. Severe diabetic complications are noted in patients with subclinical hypothyroidism. Subclinical hypothyroidism is seen commonly among females. Diabetes with hyperthyroidism has poor glycemic control

Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus

The Korean Journal of Internal Medicine ◽

10.3904/kjim.2015.198 ◽

2016 ◽

Vol 31 (4) ◽

pp. 703-711 ◽

Cited By ~ 6

Author(s):

Jae Ho Cho ◽

Ho Jin Kim ◽

Jun Ho Lee ◽

Il Rae Park ◽

Jun Sung Moon ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Glycemic Control ◽

Poor Glycemic Control

Evaluation of thyroid dysfunction among type 2 diabetic patients

Asian Journal of Medical Sciences ◽

10.3126/ajms.v6i3.10814 ◽

2014 ◽

Vol 6 (3) ◽

pp. 33-37

Author(s):

Pranav Kumar Raghuwanshi ◽

Devendra Pratap Singh Rajput ◽

Bhupendra Kumar Ratre ◽

Roopesh Jain ◽

Narmada Patel ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Thyroid Dysfunction ◽

Diabetic Patients ◽

Subclinical Hyperthyroidism ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

Background: Diabetes mellitus is a very common endocrinal disorders and incidence of thyroid dysfunction also rising in India and world over. Thyroid hormones directly control insulin secretion and insulin clearance. Diabetes also may affect the thyroid function to variable extent first at the level of hypothalamic control of TSH release and second at peripheral tissue by converting T4 to T3. Aims and Objectives: The present study was carried out aiming to evaluate thyroid dysfunction among type 2 diabetes mellitus patients. Material and Methods: Study included total 80 subjects. Thyroid dysfunction was evaluated by investigating the subjects for Total tri-iodo-thyronine (T3), Total thyroxine (T4) and thyroid stimulating hormone (TSH). Plasma glucose was estimated by- GOD-POD method and Thyroid profile was estimated by- CLIA (chemiluminescence immunoassay) system. Statistical analysis was performed using software statistical package for social sciences (SPSS) version 20, unpaired T test, Pearson’s correlation. Results: In type 2 diabetic patients the prevalence of hypothyroidism and subclinical hypothyroidism was found to be 4(10.00%) and 6(15.00%) respectively, while the prevalence of subclinical hyperthyroidism and hyperthyroidism was found to be 0(0.0%) and 1(2.5%) respectively. In non diabetic healthy subjects the prevalence of hypothyroidism and subclinical hypothyroidism was found to be 1(2.5%) and 3(7.5%) respectively while the prevalence of subclinical hyperthyroidism and hyperthyroidism was found to be 0(0.0%) and 0(0.0%) respectively. Conclusion: The prevalence of thyroid dysfunction was found to be higher in type 2 diabetes mellitus subjects as compared to non-diabetic subjects. DOI: http://dx.doi.org/10.3126/ajms.v6i3.10814Asian Journal of Medical Sciences Vol.6(3) 2015 33-37

PROPORTION OF THYROID DYSFUNCTION IN TYPE 2 DIABETES MELLITUS

10.36106/ijsr/6004234 ◽

2021 ◽

pp. 39-40

Author(s):

Shubhendu Kumar Suman ◽

Anil Kumar ◽

Uday Narayan Singh

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Prospective Study ◽

Thyroid Dysfunction ◽

Diabetic Patients ◽

Thyroid Disorders ◽

Type 2 Diabetic Patients ◽

Low T3

Type 2 diabetic patients show thyroid disorders that may aggravate the metabolic imbalance. In this study, we evaluated the prevalence of abnormal thyroid dysfunction in type 2 diabetes mellitus. This prospective study was conducted among 100 diabetic patients (cases) which were compared with age and sex matched 50 non-diabetic control subjects. TSH (Thyroid Stimulating Hormone), Triiodothyronine (T3) and Thyroxine (T4) were measured. Fasting Plasma glucose and Post Prandial blood glucose is also measured. The result of this prospective study showed, the diabetic patients in the present study although clinically euthyroid show a low level of circulating T3 to which the term “ Low T3 syndrome”given. But there is high prevalence of thyroid disorders in the diabetic population in other studies which indicates that the screening for thyroid disease among diabetic patients should be routinely performed.

Lack of Association between Poor Glycemic Control in T2DM and Subclinical Hypothyroidism

Journal of Thyroid Research ◽

10.1155/2020/8121395 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Pragya Sharma ◽

Rashmi Sinha ◽

Anupa Prasad ◽

J. K. Mitra

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Glycemic Control ◽

Myocardial Dysfunction ◽

Poor Glycemic Control ◽

High Prevalence ◽

Serum Tsh

Background. Hypothyroidism is a highly prevalent and multifactorial disorder and has been implicated in the causation of dyslipidemia, dermatological diseases, atherosclerosis, and myocardial dysfunction, as well as endothelial dysfunction. The relationship between subclinical hypothyroidism and type 2 diabetes mellitus is not well established. In the present study, we attempt to find out the prevalence of subclinical hypothyroidism in type 2 diabetes mellitus and its association with glycemic control. Materials and Methods. This was an observational study in which 205 consecutive patients of T2DM visiting the outpatient department of medicine were recruited. Serum TSH, free thyroxine, free triiodothyronine, and lipid profile, as well as HbA1c assays, were done in the study participants, and they were categorized into three groups by HbA1c: <7%, 7–9%, and >9%. Results. There is a high prevalence of subclinical hypothyroidism in type 2 DM patients. Mean HbA1c in diabetics without SCH was 7.89%, whereas it was 8.33% in diabetics with SCH. This difference was statistically not significant. TSH was not found to be significantly associated with HbA1c. Conclusion. High prevalence of SCH in T2DM patients suggests that there is a need for regular follow-up to check the progression of SCH to overt hypothyroidism. High serum TSH is not a predictor of poor glycemic control.

Thyroid dysfunction prevalence and relation to glycemic control in patients with type 2 diabetes mellitus

Diabetes & Metabolic Syndrome Clinical Research & Reviews ◽

10.1016/j.dsx.2019.07.020 ◽

2019 ◽

Vol 13 (4) ◽

pp. 2513-2517 ◽

Cited By ~ 6

Author(s):

Essmat Hassan Elgazar ◽

Noha Elsayed Esheba ◽

Safenaz Alsaeed Shalaby ◽

Wael Farrag Mohamed

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Glycemic Control ◽

Thyroid Dysfunction

Prevalence of Thyroid Disorders in Patients of Type 2 Diabetes Mellitus

International Journal of Medical and Dental Sciences ◽

10.19056/ijmdsjssmes/2013/v2i2/86773 ◽

2013 ◽

Vol 2 (2) ◽

pp. 153 ◽

Cited By ~ 1

Author(s):

G. Jain ◽

T. S. Marwaha ◽

A. Khurana ◽

P. S. Dhoat

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Thyroid Dysfunction ◽

Age Distribution ◽

Diabetic Control ◽

Diabetic Patients ◽

Thyroid Disorders ◽

Thyroid Disorder

Background:Diabetes has become a major health challenge worldwide. Various studies have found that diabetes and thyroid disorders mutually influence each other and both disorders tend to coexist.Objective: To find out the prevalence of thyroid disorders in patients of type 2 diabetes mellitus.Material and Methods: The study was conducted on 200 patients of type 2 diabetes mellitus aged between 40-70 years. All the patients were evaluated for thyroid dysfunction by testing thyroid profile (T3, T4&TSH). The correlation of prevalence of thyroid disorder with gender distribution, age distribution, HbA1C, duration of diabetes, hypertension, family history of thyroid disorder, BMI, usage of OHA's and insulin and dyslipidemia was then done. The observations and interpretations were recorded and results obtained were statistically analyzed.Results: There was a high prevalence (16%) of thyroid disorders in patients of type 2 diabetes mellitus, most common was subclinical hypothyroidism (7.5%) which was further found to be more in females, elderly patients, patients with uncontrolled diabetes i.e. HbA1C values ≥7 or patients on insulin and patients with BMI <30.Conclusions: Screening of thyroid dysfunction should be done in all diabetic patients especially in patients with poor diabetic control.