Serum intestinal fatty acid binding protein level for early diagnosis and prediction of severity of necrotizing enterocolitis

2011 ◽  
Vol 87 (10) ◽  
pp. 659-661 ◽  
Author(s):  
Cumhur Aydemir ◽  
Dilek Dilli ◽  
Serife Suna Oguz ◽  
Hulya Ozkan Ulu ◽  
Nurdan Uras ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Early Diagnosis ◽  
Necrotizing Enterocolitis ◽  
Protein Level ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Serologic Intestinal-Fatty Acid Binding Protein in Necrotizing Enterocolitis Diagnosis: A Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Shupeng Cheng ◽  
Jialin Yu ◽  
Min Zhou ◽  
Yan Tu ◽  
Qi Lu
Keyword(s):  
Fatty Acid ◽  
Early Diagnosis ◽  
Diagnostic Accuracy ◽  
Necrotizing Enterocolitis ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Premature Neonates ◽  
Acid Binding Protein ◽  
Significant Difference

Background. Previous studies showed that intestinal-fatty acid binding protein (I-FABP) may be a valid and promising serologic biomarker for early diagnosis of necrotizing enterocolitis (NEC).Objective. To investigate the early diagnostic value of serologic I-FABP in NEC for the premature neonates.Methods. All major databases were searched from January 1, 1990, to May 1, 2015. We used Meta-Disc 1.4 and Revman5.0 software to calculate the diagnostic accuracy.Results. Seven studies with 444 subjects were identified. The pooled sensitivity of I-FABP was 0.67 for NEC I, 0.74 for NEC II, and 0.83 for NEC III, and the pooled specificity was 0.84, respectively, which showed a moderate diagnostic accuracy. The area under curve (AUC) for each stage was 0.75 (Q⁎=0.69), 0.82 (Q⁎=0.76), and 0.91 (Q⁎=0.84). The diagnostic threshold analysis showed no significant difference in threshold effect. The metaregression showed that the cut-off value has the largest effect on heterogeneity. The funnel plots indicated the existence of publication bias.Conclusion. I-FABP is a valid serologic biomarker for early diagnosis in NEC for the premature neonates with a moderate accuracy.

Clinical assessment of heart-type fatty acid binding protein in early diagnosis of acute coronary syndrome

2008 ◽  
Vol 15 (3) ◽  
pp. 140-144 ◽  
Author(s):  
Hector Alonso Valle ◽  
Luis García-Castrillo Riesgo ◽  
Miguel Sántalo Bel ◽  
Francisco Epelde Gonzalo ◽  
Miguel Sánchez Sanchez ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Fatty Acid ◽  
Early Diagnosis ◽  
Clinical Assessment ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Coronary Syndrome ◽  
Acid Binding Protein

scholarly journals Low Abdominal NIRS Values and Elevated Plasma Intestinal Fatty Acid-Binding Protein in a Premature Piglet Model of Necrotizing Enterocolitis

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0125437 ◽  
Author(s):  
Irving J. Zamora ◽  
Barbara Stoll ◽  
Cecilia G. Ethun ◽  
Fariha Sheikh ◽  
Ling Yu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Necrotizing Enterocolitis ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Elevated Plasma ◽  
Fatty Acid Binding ◽  
Acid Binding Protein
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