scholarly journals What Do Carotid Intima-Media Thickness and Plaque Add to the Prediction of Stroke and Cardiovascular Disease Risk in Older Adults? The Cardiovascular Health Study

2014 ◽  
Vol 27 (9) ◽  
pp. 998-1005.e2 ◽  
Author(s):  
Julius M. Gardin ◽  
Traci M. Bartz ◽  
Joseph F. Polak ◽  
Daniel H. O’Leary ◽  
Nathan D. Wong
Keyword(s):  
Cardiovascular Disease ◽  
Older Adults ◽  
Cardiovascular Health ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Media Thickness

scholarly journals The Association of Self-Reported Muscle-Strengthening Activities With Carotid Intima–Media Thickness in Older Adults: Cooper Center Longitudinal Study

2020 ◽  
Vol 28 (4) ◽  
pp. 534-539
Author(s):  
Joowon Lee ◽  
Baojiang Chen ◽  
Harold W. Kohl ◽  
Carolyn E. Barlow ◽  
Chong Do Lee ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Older Adults ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional ◽  
Muscle Strengthening ◽  
Media Thickness

The purpose of the current investigation was to examine the cross-sectional associations of participation in muscle-strengthening activities (MSAs) with carotid intima–media thickness (CIMT) among older adults. The data are from 2,557 older adult participants enrolled in an observational cohort who reported no history of cardiovascular disease. MSA was determined using a questionnaire. Carotid ultrasound was performed to measure the CIMT of the common carotid artery bilaterally. Logistic regression models were constructed to estimate the association of MSA with CIMT after adjustment for potential confounders. The participants were aged 68.6 ± 7.0 years, and the majority were male (71.7%) and White (96.5%); 18% had abnormal CIMT. Meeting the physical activity guidelines for MSA was inversely associated with abnormal CIMT after adjustment for age and sex. However, this observed inverse relation became statistically null after further adjustment for cardiovascular disease risk factors, including aerobic physical activity.

scholarly journals Is Carotid Intima-Media Thickness Useful in Cardiovascular Disease Risk Assessment?

Stroke ◽  
2001 ◽  
Vol 32 (7) ◽  
pp. 1532-1538 ◽  
Author(s):  
Antonio Iglesias del Sol ◽  
Karel G.M. Moons ◽  
Monika Hollander ◽  
Albert Hofman ◽  
Peter J. Koudstaal ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Assessment ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

scholarly journals Serum Fasting Non-esterified Fatty Acids and Carotid Artery Intima-Media Thickness in Older Adults: The Cardiovascular Health Study

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1043-1043
Author(s):  
Neil Huang ◽  
Petra Bůžková ◽  
Nirupa Matthan ◽  
Luc Djoussé ◽  
Jorge Kizer ◽  
...  
Keyword(s):  
Older Adults ◽  
Carotid Artery ◽  
Cardiovascular Health ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Fasting Serum ◽  
Media Thickness ◽  
Linoelaidic Acid

Abstract Objectives Carotid artery intima-media thickness (CIMT) has been used as an early indicator of subclinical atherosclerosis. Multiple studies have identified significant associations between plasma total non-esterified fatty acid (NEFA) concentrations and risk factors associated with subclinical atherosclerosis. However, the relationship between CIMT and serum NEFA is less clear. We hypothesized fasting serum total, individual saturated, and trans NEFA are positively associated with, and individual monounsaturated, n-6 polyunsaturated (PUFA) and n-3 PUFA NEFA are inversely associated with, CIMT. Methods We investigated the associations between fasting serum NEFA, and CIMT assessed in 1998–1999 among Cardiovascular Health Study (CHS) participants (N = 1,569) not taking anti-diabetic medication. A total of 35 individual NEFAs were measured in stored specimens from 1996–1997 using gas chromatography. CIMT was determined using ultrasound images, and was defined as the sum of the maximum common CIMT at the far wall divided by its standard deviation (SD) and the maximum internal CIMT at the far wall divided by its SD. At baseline, mean age was 77.3 ± 4.2, body mass index (BMI) was 26.8 ± 4.3 and 64% were female. Associations were assessed by linear regression, with adjustments for other individual NEFAs, age, sex, race, field center, education, smoking, BMI, physical activity, alcohol consumption, eGFR, serum albumin, hyperglycemia, hypertension, use of anti-hypertensive, statin, and other lipid-lowering drugs. Results In adjusted models per SD increment, linoelaidic acid (trans18:2) was positively associated with CIMT [β (95% confidence interval): 10.4 (0.99, 19.8), P = 0.03], and α-linolenic acid (18:3n-3) was marginally associated with lower CIMT [−21.2 (−42.6, 0.2), P = 0.05]. No significant associations were observed between total NEFAs or any other individual NEFAs (SFA, MUFA, and n-6 PUFA) and CIMT. Conclusions In this large community-based cohort of older adults, higher concentration of linoelaidic acid was positively associated with CIMT, suggesting the importance of partially hydrogenated fat in the development of subclinical atherosclerosis in older adults. Overall, however, serum fasting NEFAs were largely unrelated to subclinical atherosclerosis in CHS participants. Funding Sources NIH, NHLBI, USDA.

scholarly journals Interaction between Fibrinogen and IL-6 Genetic Variants and Associations with Cardiovascular Disease Risk in the Cardiovascular Health Study

2010 ◽  
Vol 74 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Cara L. Carty ◽  
Patrick Heagerty ◽  
Susan R. Heckbert ◽  
Gail P. Jarvik ◽  
Leslie A. Lange ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Genetic Variants ◽  
Cardiovascular Health ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Health Study ◽  
Cardiovascular Health Study
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