Promoter polymorphism of the matrix metalloproteinase 3 gene is associated with regurgitation and left ventricular remodelling in mitral valve prolapse patients

SummaryMatrix metalloproteinase (MMP) 3 plays an important role in the pathogenesis of myocardial infarction (MI). Up to now, there has been conflicting data regarding the possible contribution of the MMP3 -1612 5A/6A promoter polymorphism to MI. In this study, we have investigated the possible association of three polymorphisms (-1612 5A/6A, -376C/G, Glu45Lys) in the MMP3 gene with MI in a Chinese Han population. The polymorphisms were analyzed in 509 patients with MI, and in 518 healthy controls. The frequency of the 5A allele was 14% in the healthy controls, which is less than in Western populations (40%-52%). Logistic regression analyses of individual polymorphisms indicated that individuals carrying the -1612 5A allele had an increased risk of MI (odds ratio [OR] 1.75, 95% confidence interval [CI] 1.28 to 2.40), as did those carrying the -376 G allele (OR 1.78, 95% CI 1.33 to 2.38). The three polymorphisms studied were found to be in strong linkage disequilibria. Haplotype analyses showed that the 5A-G-Lys haplotype (-1612 5A, -376G and 45Lys) was independently associated with susceptibility to MI. Taken together, the effect of the MMP3 polymorphisms studied may be attributable to the -1612 5A/6A polymorphism. We conclude that the MMP3 -1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of suffering MI.

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MITRAL VALVE LEAFLET ABNORMALITIES CORRELATE WITH LEFT VENTRICULAR REMODELLING AND OBSTRUCTION IN HYPERTROPHIC CARDIOMYOPATHY: A QUANTITATIVE 3D TRANSTHORACIC ECHOCARDIOGRAPHIC STUDY

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(14)61075-5 ◽

2014 ◽

Vol 63 (12) ◽

pp. A1075

Author(s):

Denisa Muraru ◽

Chiara Calore ◽

Paola Melacini ◽

Umberto Cucchini ◽

Sorina Mihaila ◽

...

Keyword(s):

Hypertrophic Cardiomyopathy ◽

Mitral Valve ◽

Left Ventricular ◽

Valve Leaflet ◽

Ventricular Remodelling ◽

Left Ventricular Remodelling ◽

Mitral Valve Leaflet ◽

Echocardiographic Study

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The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach

Disease Markers ◽

10.1155/2004/715745 ◽

2004 ◽

Vol 20 (6) ◽

pp. 289-294 ◽

Cited By ~ 9

Author(s):

Paul G. McGlinchey ◽

Mark S. Spence ◽

Chris C. Patterson ◽

Adrian R. Allen ◽

Gillian Murphy ◽

...

Keyword(s):

Heart Disease ◽

Matrix Metalloproteinase ◽

Ischaemic Heart Disease ◽

Promoter Polymorphism ◽

Irish Population ◽

Matrix Metalloproteinase 3 ◽

The Matrix ◽

Tests Of Association ◽

Family Based ◽

Atherosclerotic Process

Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family based tests of association. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the MMP-3 -1612 5A/6A polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the MMP-3 -1612 5A/6A polymorphism is not associated with IHD.

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Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients

Journal of Human Hypertension ◽

10.1038/jhh.2011.8 ◽

2011 ◽

Vol 26 (3) ◽

pp. 171-177 ◽

Cited By ~ 24

Author(s):

R Lacchini ◽

A L B Jacob-Ferreira ◽

M R Luizon ◽

S Gasparini ◽

M C S Ferreira-Sae ◽

...

Keyword(s):

Matrix Metalloproteinase ◽

Left Ventricular ◽

Matrix Metalloproteinase 2 ◽

Ventricular Remodelling ◽

Left Ventricular Remodelling ◽

Hypertensive Patients

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Effect of rosuvastatin and benazepril on matrix metalloproteinase-2, matrix metalloproteinase-9 and leukotriene B4 of patients with acute myocardial infarction

Tropical Journal of Pharmaceutical Research ◽

10.4314/tjpr.v18i3.26 ◽

2021 ◽

Vol 18 (3) ◽

pp. 625-630

Author(s):

Li Sai ◽

Zhang YanQiu ◽

Cui DongMei ◽

Li YinJun

Keyword(s):

Matrix Metalloproteinase ◽

Cardiovascular Events ◽

Serum Levels ◽

Leukotriene B4 ◽

Left Ventricular ◽

Matrix Metalloproteinase 2 ◽

Control Group ◽

Study Group ◽

Ventricular Remodelling ◽

Left Ventricular Remodelling

Purpose: To investigate the effects of rosuvastatin and benazepril on matrix metalloproteinase-2 (MMP-2), MMP-9 and leukotriene B4 (LTB4) of patients with acute myocardial infarction (AMI). Methods: Fifty-six patients with AMI were selected. They were randomly divided into control and study groups. Thirty healthy people were used in the normal group. On the basis of conventional therapy, patients in the control group were given rosuvastatin orally, while those in the study group received rosuvastatin and benazepril orally. The duration of treatment in both groups was 3 months. Serum levels of MMP-2, MMP-9 and LTB4, and incidence of left ventricular remodelling and recurrence of cardiovascular events were determined before and after treatment for both groups. Results: MMP-2, MMP-9 and LTB4 levels in serum were significantly lower for the two groups after treatment, when compared to pre-treatment values, and significantly lower in the study group (p < 0.05). Left ventricular remodelling was lower in the study group than in the control group (p < 0.05). Recurrence of cardiovascular events declined significantly in the study group, relative to control (p > 0.05). Conclusion: Rosuvastatin and benazepril significantly reduce serum levels of MMP-2, MMP-9 and LTB4 in AMI patients, and thus can potentially prevent ventricular remodelling, improve prognosis and reduce recurrence rate.

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