scholarly journals The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach

2004 ◽  
Vol 20 (6) ◽  
pp. 289-294 ◽  
Author(s):  
Paul G. McGlinchey ◽  
Mark S. Spence ◽  
Chris C. Patterson ◽  
Adrian R. Allen ◽  
Gillian Murphy ◽  
...  
Keyword(s):  
Heart Disease ◽  
Matrix Metalloproteinase ◽  
Ischaemic Heart Disease ◽  
Promoter Polymorphism ◽  
Irish Population ◽  
Matrix Metalloproteinase 3 ◽  
The Matrix ◽  
Tests Of Association ◽  
Family Based ◽  
Atherosclerotic Process

Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family based tests of association. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the MMP-3 -1612 5A/6A polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the MMP-3 -1612 5A/6A polymorphism is not associated with IHD.

Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population

2004 ◽  
Vol 92 (10) ◽  
pp. 867-873 ◽  
Author(s):  
Xiaoyang Zhou ◽  
Jianfeng Huang ◽  
Jianhong Chen ◽  
Shaoyong Su ◽  
Runsheng Chen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Matrix Metalloproteinase ◽  
Promoter Polymorphism ◽  
Chinese Han Population ◽  
Healthy Controls ◽  
Chinese Han ◽  
Han Population ◽  
Matrix Metalloproteinase 3 ◽  
Increased Risk ◽  
The Matrix

SummaryMatrix metalloproteinase (MMP) 3 plays an important role in the pathogenesis of myocardial infarction (MI). Up to now, there has been conflicting data regarding the possible contribution of the MMP3 -1612 5A/6A promoter polymorphism to MI. In this study, we have investigated the possible association of three polymorphisms (-1612 5A/6A, -376C/G, Glu45Lys) in the MMP3 gene with MI in a Chinese Han population. The polymorphisms were analyzed in 509 patients with MI, and in 518 healthy controls. The frequency of the 5A allele was 14% in the healthy controls, which is less than in Western populations (40%-52%). Logistic regression analyses of individual polymorphisms indicated that individuals carrying the -1612 5A allele had an increased risk of MI (odds ratio [OR] 1.75, 95% confidence interval [CI] 1.28 to 2.40), as did those carrying the -376 G allele (OR 1.78, 95% CI 1.33 to 2.38). The three polymorphisms studied were found to be in strong linkage disequilibria. Haplotype analyses showed that the 5A-G-Lys haplotype (-1612 5A, -376G and 45Lys) was independently associated with susceptibility to MI. Taken together, the effect of the MMP3 polymorphisms studied may be attributable to the -1612 5A/6A polymorphism. We conclude that the MMP3 -1612 5A/6A polymorphism is associated with MI in our population, implying that individuals of the 5A allele carriers have an increased risk of suffering MI.

Cytokine gene polymorphisms in ischaemic heart disease: investigation using family-based tests of association

2004 ◽  
Vol 82 (11) ◽  
pp. 756-761 ◽  
Author(s):  
Paul G. McGlinchey ◽  
Mark S. Spence ◽  
Chris C. Patterson ◽  
Adrian R. Allen ◽  
Gillian Murphy ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Gene Polymorphisms ◽  
Cytokine Gene ◽  
Tests Of Association ◽  
Cytokine Gene Polymorphisms ◽  
Family Based

THE PROMOTER POLYMORPHISM OF THE MATRIX METALLOPROTEINASE 3 (MMP-3) GENE IN WOMEN WITH OVARIAN CANCER

2003 ◽  
Vol 13 (Suppl 1) ◽  
pp. 64.3-64
Author(s):  
K. Szyllo ◽  
H. Romanowicz-Makowska ◽  
B. Smolarz ◽  
M. Niewiadomski ◽  
E. Kozlowska ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Matrix Metalloproteinase ◽  
Promoter Polymorphism ◽  
Matrix Metalloproteinase 3 ◽  
The Matrix

Association of the Matrix Metalloproteinase-3 (MMP-3) Promoter Polymorphism With Celiac Disease in Male Subjects

2005 ◽  
Vol 66 (6) ◽  
pp. 715-719 ◽  
Author(s):  
Barbara Mora ◽  
Margherita Bonamico ◽  
Mirella Ferri ◽  
Francesca Megiorni ◽  
John Osborn ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Matrix Metalloproteinase ◽  
Promoter Polymorphism ◽  
Matrix Metalloproteinase 3 ◽  
The Matrix ◽  
Male Subjects
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