Bifunctional μ opioid and σ1 receptor ligands as novel analgesics with reduced side effects

2021 ◽  
pp. 113658
Author(s):  
Tao Zhuang ◽  
Jiaying Xiong ◽  
Shuaishuai Hao ◽  
Wei Du ◽  
Zhenming Liu ◽  
...  
Keyword(s):  
Side Effects ◽  
Receptor Ligands ◽  
Σ1 Receptor

5D-QSAR for spirocyclic σ1 receptor ligands by Quasar receptor surface modeling

2010 ◽  
Vol 45 (7) ◽  
pp. 3116-3124 ◽  
Author(s):  
Christoph Oberdorf ◽  
Thomas J. Schmidt ◽  
Bernhard Wünsch
Keyword(s):  
Surface Modeling ◽  
Receptor Ligands ◽  
Σ1 Receptor

scholarly journals Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson’s Disease

Biomolecules ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 142 ◽  
Author(s):  
Fabio Bello ◽  
Mario Giannella ◽  
Gianfabio Giorgioni ◽  
Alessandro Piergentili ◽  
Wilma Quaglia
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Side Effects ◽  
Elevated Liver Enzyme ◽  
Therapeutic Potential ◽  
Motor Complication ◽  
Receptor Ligands ◽  
Dopaminergic Drugs ◽  
The Many ◽  
Non Motor Symptoms

Levodopa (LD) is the most effective drug in the treatment of Parkinson’s disease (PD). However, although it represents the “gold standard” of PD therapy, LD can cause side effects, including gastrointestinal and cardiovascular symptoms as well as transient elevated liver enzyme levels. Moreover, LD therapy leads to LD-induced dyskinesia (LID), a disabling motor complication that represents a major challenge for the clinical neurologist. Due to the many limitations associated with LD therapeutic use, other dopaminergic and non-dopaminergic drugs are being developed to optimize the treatment response. This review focuses on recent investigations about non-dopaminergic central nervous system (CNS) receptor ligands that have been identified to have therapeutic potential for the treatment of motor and non-motor symptoms of PD. In a different way, such agents may contribute to extending LD response and/or ameliorate LD-induced side effects.

Predicting the Antinociceptive Efficacy of σ1 Receptor Ligands by a Novel Receptor Fluorescence Resonance Energy Transfer (FRET) Based Biosensor

2013 ◽  
Vol 57 (1) ◽  
pp. 238-242 ◽  
Author(s):  
Maricel Gómez-Soler ◽  
Víctor Fernández-Dueñas ◽  
Enrique Portillo-Salido ◽  
Pilar Pérez ◽  
Daniel Zamanillo ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Fluorescence Resonance Energy Transfer ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Receptor Ligands ◽  
Σ1 Receptor ◽  
Fluorescence Resonance

Synthesis and Structure–Activity Relationship Study of a New Series of Selective σ1 Receptor Ligands for the Treatment of Pain: 4-Aminotriazoles

2015 ◽  
Vol 58 (5) ◽  
pp. 2441-2451 ◽  
Author(s):  
José Luis Díaz ◽  
Ute Christmann ◽  
Ariadna Fernández ◽  
Antoni Torrens ◽  
Adriana Port ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Receptor Ligands ◽  
Σ1 Receptor ◽  
Structure Activity ◽  
Relationship Study

Identification, pharmacological evaluation and binding mode analysis of novel chromene and chromane based σ1 receptor ligands

2014 ◽  
Vol 83 ◽  
pp. 526-533 ◽  
Author(s):  
Erik Laurini ◽  
Dipak Harel ◽  
Domenico Marson ◽  
Dirk Schepmann ◽  
Thomas J. Schmidt ◽  
...  
Keyword(s):  
Binding Mode ◽  
Mode Analysis ◽  
Receptor Ligands ◽  
Pharmacological Evaluation ◽  
Σ1 Receptor

Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring

2015 ◽  
Vol 58 (21) ◽  
pp. 8601-8615 ◽  
Author(s):  
Alessandro Bonifazi ◽  
Fabio Del Bello ◽  
Valerio Mammoli ◽  
Alessandro Piergentili ◽  
Riccardo Petrelli ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptor Antagonists ◽  
Receptor Ligands ◽  
Receptor Antagonists ◽  
Σ1 Receptor ◽  
Dioxane Ring

Enantiomerically Pure 1,3-Dioxanes as Highly Selective NMDA and σ1 Receptor Ligands

2012 ◽  
Vol 55 (20) ◽  
pp. 8953-8957 ◽  
Author(s):  
Jens Köhler ◽  
Klaus Bergander ◽  
Jörg Fabian ◽  
Dirk Schepmann ◽  
Bernhard Wünsch
Keyword(s):  
Receptor Ligands ◽  
Enantiomerically Pure ◽  
Σ1 Receptor
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