Synthesis and analysis of dihydrotetrabenazine derivatives as novel vesicular monoamine transporter 2 inhibitors

2021 ◽  
pp. 113718
Author(s):  
Yifei Yang ◽  
Dawei Yu ◽  
Xiaoyin Zhu ◽  
Guangying Du ◽  
Wenyan Wang ◽  
...  
Keyword(s):  
Vesicular Monoamine Transporter ◽  
Monoamine Transporter ◽  
Vesicular Monoamine Transporter 2

scholarly journals Transcriptional activation of vesicular monoamine transporter 2 in the pre-B cell line Ea3.123

1999 ◽  
Vol 337 (2) ◽  
pp. 193 ◽  
Author(s):  
Fiona WATSON ◽  
Damian G. DEAVALL ◽  
Janet A. MACRO ◽  
Rachel KIERNAN ◽  
Rod DIMALINE
Keyword(s):  
B Cell ◽  
Cell Line ◽  
Transcriptional Activation ◽  
Vesicular Monoamine Transporter ◽  
Monoamine Transporter ◽  
Vesicular Monoamine Transporter 2

Platelet Vesicular Monoamine Transporter 2 Density in the Disruptive Behavior Disorders

2011 ◽  
Vol 21 (4) ◽  
pp. 341-344 ◽  
Author(s):  
Gil Zalsman ◽  
Dorit Aslanov-Farbstein ◽  
Moshe Rehavi ◽  
Netta Roz ◽  
Robert Vermeiren ◽  
...  
Keyword(s):  
Disruptive Behavior ◽  
Behavior Disorders ◽  
Disruptive Behavior Disorders ◽  
Vesicular Monoamine Transporter ◽  
Monoamine Transporter ◽  
Vesicular Monoamine Transporter 2

scholarly journals VNUT and VMAT2 segregate within sympathetic varicosities and localize near preferred Cav2 isoforms in the rat tail artery

2019 ◽  
Vol 316 (1) ◽  
pp. H89-H105 ◽  
Author(s):  
Somayeh Mojard Kalkhoran ◽  
Sarah Heather Jane Chow ◽  
Jagdeep Singh Walia ◽  
Cynthia Gershome ◽  
Nickolas Saraev ◽  
...  
Keyword(s):  
Large Fraction ◽  
Atp Release ◽  
Sympathetic Nerves ◽  
Vesicular Monoamine Transporter ◽  
Rat Tail Artery ◽  
Monoamine Transporter ◽  
Vesicular Monoamine Transporter 2 ◽  
Tail Artery ◽  
Vesicle Pools ◽  
Rat Tail

ATP and norepinephrine (NE) are coreleased from peripheral sympathetic nerve terminals. Whether they are stored in the same vesicles has been debated for decades. Preferential dependence of NE or ATP release on Ca2+ influx through specific voltage-gated Ca2+ channel (Cav2) isoforms suggests that NE and ATP are stored in separate vesicle pools, but simultaneous imaging of NE and ATP containing vesicles within single varicosities has not been reported. We conducted an immunohistochemical study of vesicular monoamine transporter 2 (VMAT2/SLC18A2) and vesicular nucleotide translocase (VNUT/SLC17A9) as markers of vesicles containing NE and ATP in sympathetic nerves of the rat tail artery. A large fraction of varicosities exhibited neighboring, rather than overlapping, VNUT and VMAT2 fluorescent puncta. VMAT2, but not VNUT, colocalized with synaptotagmin 1. Cav2.1, Cav2.2, and Cav2.3 are expressed in nerves in the tunica adventitia. VMAT2 preferentially localized adjacent to Cav2.2 and Cav2.3 rather than Cav2.1. VNUT preferentially localized adjacent to Cav2.3 > Cav2.2 >> Cav2.1. With the use of wire myography, inhibition of field-stimulated vasoconstriction with the Cav2.3 blocker SNX-482 (0.25 µM) mimicked the effects of the P2X inhibitor suramin (100 µM) rather than the α-adrenergic inhibitor phentolamine (10 µM). Variable sensitivity to SNX-482 and suramin between animals closely correlated with Cav2.3 staining. We concluded that a majority of ATP and NE stores localize to separate vesicle pools that use different synaptotagmin isoforms and that localize near different Cav2 isoforms to mediate vesicle release. Cav2.3 appears to play a previously unrecognized role in mediating ATP release in the rat tail artery. NEW & NOTEWORTHY Immunofluorescence imaging of vesicular nucleotide translocase and vesicular monoamine transporter 2 in rat tail arteries revealed that ATP and norepinephrine, classical cotransmitters, localize to well-segregated vesicle pools. Furthermore, vesicular nucleotide translocase and vesicular monoamine transporter 2 exhibit preferential localization with specific Cav2 isoforms. These novel observations address long-standing debates regarding the mechanism(s) of sympathetic neurotransmitter corelease.

scholarly journals Methylphenidate Redistributes Vesicular Monoamine Transporter-2: Role of Dopamine Receptors

2002 ◽  
Vol 22 (19) ◽  
pp. 8705-8710 ◽  
Author(s):  
Verónica Sandoval ◽  
Evan L. Riddle ◽  
Glen R. Hanson ◽  
Annette E. Fleckenstein
Keyword(s):  
Dopamine Receptors ◽  
Vesicular Monoamine Transporter ◽  
Monoamine Transporter ◽  
Vesicular Monoamine Transporter 2

Study of Vesicular Monoamine Transporter 2 in Myopic Retina Using [18F]FP-(+)-DTBZ

2018 ◽  
Vol 20 (5) ◽  
pp. 771-779 ◽  
Author(s):  
Yu Sun ◽  
Ning Zhao ◽  
Wangyuan Liu ◽  
Miao Liu ◽  
Zizhao Ju ◽  
...  
Keyword(s):  
Vesicular Monoamine Transporter ◽  
Monoamine Transporter ◽  
Vesicular Monoamine Transporter 2
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