Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors

2021 ◽  
pp. 113916
Author(s):  
Soo-Yeon Hwang ◽  
Aarajana Shrestha ◽  
Seojeong Park ◽  
Ganesh Bist ◽  
Surendra Kunwar ◽  
...  
Keyword(s):  
Topoisomerase Inhibitors

EXPERIMENTAL STUDY OF THE EFFICACY OF L-LYSINE-A-OXIDASE TRICHODERMA CF. AUREOVIRIDE RIFAI ON MODELS OF XENOGRAFTS OF HUMAN TUMORS IN ATHYMIC MICE AND EVALUATION OF SYNERGISM WITH CISPLATIN OR TOPOISOMERASE INHIBITORS

2017 ◽  
Vol 63 (3) ◽  
pp. 497-505
Author(s):  
Vadim Pokrovskiy ◽  
Yelena Lukasheva ◽  
Nikolay Chernov ◽  
Yelena Treshchalina
Keyword(s):  
Experimental Study ◽  
Life Expectancy ◽  
Therapeutic Benefit ◽  
Human Tumors ◽  
Lymphocytic Leukemia ◽  
Antitumor Drugs ◽  
Athymic Mice ◽  
Lewis Lung ◽  
Topoisomerase Inhibitors ◽  
Inhibition Of Growth

The effectiveness of L-lysine-alpha oxidase Trichoderma cf. Aureoviride Rifai BKMF-4268D (LO) on models of subcutaneous xenografts of human tumors in athymic mice as well as the effectiveness of combination therapy with known antitumor drugs: cisplatin, irinotecan, etoposide on models of P388 lymphocytic leukemia, Lewis lung (LLC) and B16 melanoma was evaluated. The intraperitoneal injection of LO in a discrete regime at doses of 150-75-75-75-75 E/kg demonstrated inhibition of growth of all studied xenografts of human tumors in athymic mice. The combination of irinotecan+LO on the LLC model gave a significant summative therapeutic benefit with an increase in mouse life expectancy up to 35%. Cisplatin and LO realized a significant (p

scholarly journals Topoisomerase inhibitors modulate expression of melanocytic antigens and enhance T cell recognition of tumor cells

2010 ◽  
Vol 60 (1) ◽  
pp. 133-144 ◽  
Author(s):  
Timothy J. Haggerty ◽  
Ian S. Dunn ◽  
Lenora B. Rose ◽  
Estelle E. Newton ◽  
Sunil Martin ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Cells ◽  
Cell Recognition ◽  
Topoisomerase Inhibitors ◽  
T Cell Recognition

Topoisomerase inhibitors induce apoptosis in thymocytes

1993 ◽  
Vol 1175 (2) ◽  
pp. 147-154 ◽  
Author(s):  
Yoshiaki Onishi ◽  
Yutaro Azuma ◽  
Yutaka Sato ◽  
Yoshio Mizuno ◽  
Takushi Tadakuma ◽  
...  
Keyword(s):  
Topoisomerase Inhibitors

Mechanism of action of DNA topoisomerase inhibitors

Stem Cells ◽  
1995 ◽  
Vol 13 (4) ◽  
pp. 369-379 ◽  
Author(s):  
Monica Binaschi ◽  
Franco Zunino ◽  
Giovanni Capranico
Keyword(s):  
Mechanism Of Action ◽  
Topoisomerase Inhibitors ◽  
Dna Topoisomerase
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