scholarly journals Topoisomerase inhibitors modulate expression of melanocytic antigens and enhance T cell recognition of tumor cells

2010 ◽  
Vol 60 (1) ◽  
pp. 133-144 ◽  
Author(s):  
Timothy J. Haggerty ◽  
Ian S. Dunn ◽  
Lenora B. Rose ◽  
Estelle E. Newton ◽  
Sunil Martin ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Cells ◽  
Cell Recognition ◽  
Topoisomerase Inhibitors ◽  
T Cell Recognition

scholarly journals Heat Shock Protein-90 Inhibitors Enhance Antigen Expression on Melanomas and Increase T Cell Recognition of Tumor Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e114506 ◽  
Author(s):  
Timothy J. Haggerty ◽  
Ian S. Dunn ◽  
Lenora B. Rose ◽  
Estelle E. Newton ◽  
Franco Pandolfi ◽  
...  
Keyword(s):  
T Cell ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cells ◽  
Heat Shock Protein 90 ◽  
Antigen Expression ◽  
Cell Recognition ◽  
T Cell Recognition

Effect of Costimulation and the Microenvironment on Antigen Presentation by Leukemic Cells

Blood ◽  
1999 ◽  
Vol 94 (10) ◽  
pp. 3479-3490 ◽  
Author(s):  
A.G.S. Buggins ◽  
N. Lea ◽  
J. Gäken ◽  
D. Darling ◽  
F. Farzaneh ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
T Cell ◽  
Tumor Cells ◽  
Costimulatory Molecule ◽  
Leukemic Cells ◽  
Cell Mediated Immunity ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Th1 Cytokines

Costimulatory signals supplied by genetically modified tumor cells can enable T-cell recognition of tumor-associated antigens that were previously silent when presented by unmodified tumor cells. Although the mechanism of the CD80/CD28 costimulation has been studied extensively in the normal T-cell/antigen-presenting cell (APC) interactions, it is unclear how expression of CD80 by tumor cells mediates its effect. We demonstrate here that optimal CD80 expression on a leukemic cell enhances T-cell recognition of alloantigen primarily by lowering the level of T-cell receptor (TCR) stimulation required for activation. CD80 expression by leukemic cells leads to increased survival of activated T cells by inducing upregulation of the antiapoptotic protein BCL-2, but not BCL-XL. The cytokine microenvironment in which T cells are activated is crucial in determining their differentiation and consequently the nature of the immune response generated. Many tumor cells produce immunosuppressive cytokines that may not favor the induction of cell-mediated immunity. In this study, the presence of CD80 on leukemic cells increased T-cell activation in vitro, but this did not result in the production of Th1 cytokines. We show that this is due to a leukemia-derived soluble factor that inhibits the production of Th1 cytokines. Optimal expression of a costimulatory molecule, therefore, enhances the ability of leukemic cells to present antigen by amplifying TCR signals, but the microenvironment generated by leukemic cells may suppress the immune response required for their eradication. Thus, strategies aimed at inducing antileukemic immunity by providing leukemic cells with costimulatory functions must ensure the presence of an appropriate microenvironment.

scholarly journals Human Ovarian Tumor Cells Escape γδ T Cell Recognition Partly by Down Regulating Surface Expression of MICA and Limiting Cell Cycle Related Molecules

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e23348 ◽  
Author(s):  
Jingwei Lu ◽  
Reeva Aggarwal ◽  
Suman Kanji ◽  
Manjusri Das ◽  
Matthew Joseph ◽  
...  
Keyword(s):  
Cell Cycle ◽  
T Cell ◽  
Tumor Cells ◽  
Ovarian Tumor ◽  
Surface Expression ◽  
Cell Recognition ◽  
Γδ T Cell ◽  
T Cell Recognition ◽  
Ovarian Tumor Cells

scholarly journals Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds.

1976 ◽  
Vol 144 (4) ◽  
pp. 1134-1140 ◽  
Author(s):  
T G Rehn ◽  
J K Inman ◽  
G M Shearer
Keyword(s):  
T Cell ◽  
Target Cells ◽  
Cell Recognition ◽  
Receptor Model ◽  
Spleen Cells ◽  
Effector Cells ◽  
T Cell Recognition ◽  
Cytotoxic Effector

The specificity of C57BL/10 cytotoxic effector cells generated by in vitro sensitization with autologous spleen cells modified with a series of related nitrophenyl compounds was investigated. The failure of trinitrophenyl (TNP)-sensitized effector cells to lyse TNP-beta-alanylglycylglycyl(AGG)-modified target cells is presented as evidence contradicting the intimacy or dual receptor model or T-cell recognition in its simplest form. Data are also shown indicating that sensitization with N-(3-nitro-4-hydroxy-5-iodophenylacetyl)-AGG-modified stimulating cells generates noncross-reacting clones of cytotoxic effector cells.

T CELL RECOGNITION IN AUTOIMMUNE DISEASE

1993 ◽  
Vol 23 (s1) ◽  
pp. 11-11
Author(s):  
Paul J Fairchild ◽  
David C Wraith
Keyword(s):  
T Cell ◽  
Autoimmune Disease ◽  
Cell Recognition ◽  
T Cell Recognition

scholarly journals Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics

2012 ◽  
Vol 42 (11) ◽  
pp. 2990-3000 ◽  
Author(s):  
Eva B. Allerbring ◽  
Adil D. Duru ◽  
Hannes Uchtenhagen ◽  
Chaithanya Madhurantakam ◽  
Markus B. Tomek ◽  
...  
Keyword(s):  
T Cell ◽  
Peptide Ligand ◽  
Altered Peptide Ligand ◽  
Cell Recognition ◽  
T Cell Recognition

scholarly journals CD8+ T cell recognition of polymorphic wild-type sequence p5365–73 peptides in squamous cell carcinoma of the head and neck

2010 ◽  
Vol 59 (10) ◽  
pp. 1561-1568 ◽  
Author(s):  
Pedro A. Andrade Filho ◽  
Daisuke Ito ◽  
Albert B. DeLeo ◽  
Robert L. Ferris
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
Wild Type ◽  
T Cell Recognition ◽  
Type Sequence

T cell recognition in chronic beryllium disease

2006 ◽  
Vol 121 (2) ◽  
pp. 134-143 ◽  
Author(s):  
Massimo Amicosante ◽  
Andrew P. Fontenot
Keyword(s):  
T Cell ◽  
Cell Recognition ◽  
Chronic Beryllium Disease ◽  
T Cell Recognition ◽  
Beryllium Disease

scholarly journals In vivo clonal dominance and limited T-cell receptor usage in human CD4+ T-cell recognition of house dust mite allergens.

1993 ◽  
Vol 90 (17) ◽  
pp. 8214-8218 ◽  
Author(s):  
L. R. Wedderburn ◽  
R. E. O'Hehir ◽  
C. R. Hewitt ◽  
J. R. Lamb ◽  
M. J. Owen
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
House Dust ◽  
House Dust Mite ◽  
Cell Receptor ◽  
Cd4 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Dust Mite
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