Infant mortality associated with spina bifida: A systematic review and meta-analysis

IntroductionMaternal mental health disorders such as anxiety and depression are major public health concerns. Evidence shows a link between maternal mental health disorders and preterm birth and low birth weight. However, the impacts of maternal mental health disorders on stillbirth and infant mortality have been less investigated and inconsistent findings have been reported. Thus, using the available literature, we plan to examine whether prenatal maternal mental health disorders impact the risk of stillbirth and infant mortality.Methods and analysisThis systematic review and meta-analysis will adhere to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and will be registered with the International Prospective Register of Systematic Reviews. Systematic searches will be conducted (from database inception to December 2019) in Medline, Embase, PsycINFO and Scopus for studies examining the association of prenatal mental health disorders and stillbirth and infant mortality. The search will be limited to studies published in English language and in humans only, with no restriction on the year of publication. Two independent reviewers will evaluate records and assess the quality of individual studies. The Newcastle–Ottawa scales and GRADE (Grading of Recommendations, Assessment, Development and Evaluations) approach will be used to assess the methodological quality and bias of the included studies. In addition to a narrative synthesis, a random-effects meta-analysis will be conducted when sufficient data are available. I2 statistics will be used to assess between-study heterogeneity in the estimated effect size.Ethics and disseminationAs it will be a systematic review and meta-analysis based on previously published evidence, there will be no requirement for ethical approval. Findings will be published in a peer-reviewed journal and will be presented at various conferences.PROSPERO registration number159834.

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Association of Arsenic and Adverse Pregnancy Outcomes/Infant Mortality: a Systematic Review and Meta-Analysis

ISEE Conference Abstracts ◽

10.1289/isee.2014.o-001 ◽

2014 ◽

Vol 2014 (1) ◽

pp. 1557

Author(s):

Reginald Quansah* ◽

Frederick Ato Armah ◽

Isaac Luginaah ◽

Proscovia Bazanya Namujju ◽

Kissinger Marfoh

Keyword(s):

Systematic Review ◽

Infant Mortality ◽

Pregnancy Outcomes ◽

Meta Analysis ◽

Adverse Pregnancy Outcomes ◽

Adverse Pregnancy

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Dry care versus chlorhexidine cord care for prevention of omphalitis. Systematic review with meta-analysis

Revista Latino-Americana de Enfermagem ◽

10.1590/1518-8345.2695.3106 ◽

2019 ◽

Vol 27 ◽

Author(s):

María Dolores López-Medina ◽

Manuel Linares-Abad ◽

Ana Belén López-Araque ◽

Isabel María López-Medina

Keyword(s):

Systematic Review ◽

Mortality Rate ◽

Infant Mortality ◽

Umbilical Cord ◽

Meta Analysis ◽

Infant Mortality Rate ◽

Cord Care ◽

High Infant Mortality ◽

Umbilical Cord Care ◽

Hospital Births

ABSTRACT Objective: to compare the effect of dry care and the application of chlorhexidine to the umbilical cord of newborns at risk of developing omphalitis. Method: systematic review with meta-analysis. Clinical trials comparing dry care with the application of clorexidine to evaluate omphalitis were selected. Methodological quality was evaluated using the Consolidated Standards of Reporting Trials. Results: the joint analysis of the studies shows a significant decrease in the risk of omphalitis in the chlorhexidine group compared to the dry care group (RR=0.58, CI: 0.53-0.64). However, in the analysis by subgroups, chlorhexidine umbilical cord care did not reduce the risk of omphalitis in hospital births (RR=0.82, CI: 0.64-1.05), in countries with a low infant mortality rate (RR=0.8, CI: 0.5-1.28), or at chlorhexidine concentrations below 4% (RR=0.55, CI: 0.31-1). Chlorhexidine acted as a protective factor at a concentration of 4% (RR=0.58, CI: 0.53-0.64), when applied in cases of home births (RR=0.57, CI: 0.51-0.62), in countries with a high infant mortality rate (RR=0.57, CI: 0.52-0.63). Conclusion: dry cord care is effective in countries with low infant mortality rate and in hospital births. However, 4% chlorhexidine for umbilical cord care protects against omphalitis in home births, in countries with a high infant mortality rate.

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