Atypical endometriosis is related to a higher recurrence rate

SummaryCases of cystic bone lesions in horses and humans were reviewed in the literature. These lesions are radiolucent areas of bone, recognized as subchondral cystic lesions in the horse (SCL), intra-osseous ganglia (IOG), subchondral bone cysts secondary to osteoarthrosis (OAC), and unicameral bone cysts (UCB) in humans. Their morphology is quite similar, consisting of lesions with a distinct cyst wall, and a cavity filled with fibrous tissue and yellowish mucoid fluid. The lesions are surrounded by sclerotic bone and can be easily diagnosed radiographically. SCL, IOG and OAC occur in the subchondral bone close to the adjacent joint, whereas UCB occur in the metaphysis of long bones. Their aetiology and pathogenesis is still unknown, although primary damage to the subchondral bone, cartilage or local blood supply and growth disturbances are discussed. In this review 703 lesions of SCL in horses, 289 lesions of IOG and 1460 lesions of UCB in humans were compared in their anatomical location and clinical signs. SCL and OAC resembled each other with respect to anatomical location. A correlation of affected bones could not be found for all four groups. Clinical presentation concerning age was most similar for SCL and UCB with both lesions mainly occurring in young individuals. Gender predominance of males was present in SCL, IOG and UCB. Clinical diagnosis was either incidental, or connected with intermittent pain in all lesions except for OAC. Additionally, the lesions were also found in conjunction with degenerative joint disease (SCL, OAC) or pathological fractures (UCB). Cystic bone lesions were either treated conservatively, surgically with curettage alone, curettage in combination with grafting procedures, or intra-lesional application of corticosteroids. SCL and UCB were similar in their biological behaviour concerning their slow response to the therapy and relatively high recurrence rate. None of the cystic bone lesions were comparable, and a common aetiology and pathogenesis could not be found.In a literature review cases of cystic bone lesions in horses and humans were compared with the goal to find a common aetiology and pathogenesis. Cystic bone lesions occur in horses as subchondral cystic lesions (SCL), and in humans as either intra-osseous ganglia (IOG), subchondral cystic lesions secondary to osteoarthrosis (OAC) or unicameral bone cysts (UCB). IOG and OAC compare with SCL mainly in the anatomical location. IOG and SCL resemble each other in size, clinical signs and histology, whereas UCB and SCL show a similar biological behaviour regarding their therapeutic response and recurrence rate. None of the cystic bone lesions in humans were comparable to the SCL in horses in all aspects. A common aetiology and pathogenesis could not be established.

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ADENOMA RECURRENCE RATE AFTER LEFT- VERSUS RIGHT-SIDED COLECTOMY FOR COLON CANCER; IS THERE REALLY A DIFFERENCE BETWEEN THE TWO GROUPS?

10.1055/s-0038-1637584 ◽

2018 ◽

Author(s):

HS Moon ◽

GY Yun ◽

JS Kim ◽

SH Kang ◽

JK Sung ◽

...

Keyword(s):

Colon Cancer ◽

Recurrence Rate ◽

Adenoma Recurrence ◽

Adenoma Recurrence Rate

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COMPARATIVE STUDY IN BETWEEN INTRALESIONAL VITAMIN D3 AND INTRALESIONAL BLEOMYCIN IN THE TREATMENT OF CUTANEOUS VERRUCAE

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i8.1372 ◽

2020 ◽

Vol 4 (8) ◽

Author(s):

Shrikant . ◽

R.D. Mehta ◽

B.C. Ghiya

Keyword(s):

Partial Response ◽

Comparative Study ◽

Recurrence Rate ◽

Vitamin D3 ◽

Complete Response ◽

Recurrence Rates ◽

Additional Advantage ◽

Cost Effective Treatment ◽

Group A ◽

Group B

Background: Verruca is one of the common dermatopathologies which has multiple therapeutic options but with variable success rates, refractory cases and high recurrence rates. Nowadays, treatment with intralesional injections has gained recognition due to its effectiveness in clearing verrucae. These act by stimulating the cell-mediated immunity. Out of scores of options available for intralesional therapeutics, Vitamin D3 appears to be more promising but least evaluated. Therefore, we planned to evaluate the efficacy of intralesional Vitamin D3 in various types of cutaneous verrucae. Simultaneously the results were compared with intralesional bleomycin, also. Methods: A total of 200 patients of cutaneous verrucae with varying size and duration were included in the experimental randomized comparative study. We divided them into two groups. Group A, comprising of 100 patients, received 0.2-0.5 ml intralesional Vitamin D3 (600,000 IU, 15mg/ml) and Group B, also of hundred subjects, received intralesional Bleomycin (1 mg/ml) into the base of verrucae. A maximum of 5 verrucae were injected per session at 3 weeks interval until resolution or for a maximum of 4 sessions. Patients were followed up for 6 months after the last injection to assess the clearance status and detect any recurrence. Results: In Group A (Vitamin D3), 'Complete response', 'Partial response' and 'No response' were observed in 85.07%, 6.74% and 8.17% respectively after 4 sessions. Recurrence rate was 0.81% after 6 months. In Group B (Bleomycin), 'Complete response', 'Partial response' and 'No response' were found in 77.99%, 10.47% and 11.53% in the series. Recurrence rate was 1.71%, comparatively higher in group B. Conclusion: The efficacy of intralesional Vitamin D3 was found significantly higher as compared to intralesional Bleomycin in the treatment of cutaneous verrucae with less recurrence rates. Vitamin D3 has an additional advantage of cost-effective treatment over Bleomycin. We purpose its use, as a primary mode of treatment in various types of cutaneous verrucae. Keywords: Bleomycin, Vitamin D3, Verrucae.

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Early complications in surgery of umbilical and epigastric hernias

Perspectives in Surgery ◽

10.33699/pis.2020.99.5.207-211 ◽

2020 ◽

Vol 99 (5) ◽

pp. 207-211

Keyword(s):

Type 2 Diabetes ◽

Recurrence Rate ◽

Mesh Repair ◽

Early Complications ◽

Recurrence Rates ◽

Fascial Defect ◽

Epigastric Hernia ◽

Mesh Implantation ◽

Hernial Sac

ntroduction: Repairs of umbilical and epigastric hernias are common surgical procedures; the choice of the surgical method generally depends on the size of the hernial sac and fascial defect. Methods: Data of patients operated on for umbilical or epigastric hernias in our hospital during two years were assessed retrospectively. The study group included 264 patients; 212 had an umbilical hernia and 52 had an epigastric hernia. We assessed epidemiologic and clinical parameters and their correlation with the occurrence of early postoperative complications. We also looked for the recurrence rate, although during only a short follow-up period. Results: In the case of umbilical hernias, early complications occurred in 6.7% (11/165) after surgery with a simple suture and in 4.3% (2/47) with mesh repair, and the recurrence rates were 3% (5/165) and 21.3% (10/47), respectively. The risk of early complications was significantly higher in larger hernias. The recurrence rate increased with older age, an increased size of the hernial sac and fascial defect, and in patients with type 2 diabetes. In epigastric hernias, early complications occurred in 5.3% (1/19) after surgery with a simple suture and in 6.1% (2/33) with mesh repair. Recurrences only occurred in operations with mesh repair, in 9% (3/33). The risk of early complications was significantly higher in type 2 diabetes patients. Conclusion: Early complications were slightly more frequent in epigastric hernia repairs with mesh implantation, but this was not the case of umbilical hernias. We recommend mesh implantation in larger and borderline sized hernias to reduce the risk of recurrence.

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Recurrence rate of hyperprolactinemia after dopamine agonists withdrawal in macroprolactinoma patients

Endocrine Abstracts ◽

10.1530/endoabs.50.p297 ◽

2017 ◽

Author(s):

Raluca Trifanescu ◽

Iuliana Baranga ◽

Andra Caragheorgheopol ◽

Anda Dumitrascu ◽

Monica Gheorghiu ◽

...

Keyword(s):

Recurrence Rate ◽

Dopamine Agonists

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Intraoperative, postoperative and long-term oncosurgical safety of therapeutic mammaplasty

Orvosi Hetilap ◽

10.1556/oh.2013.29660 ◽

2013 ◽

Vol 154 (33) ◽

pp. 1291-1296 ◽

Cited By ~ 1

Author(s):

László Romics Jr. ◽

Sophie Barrett ◽

Sheila Stallard ◽

Eva Weiler-Mithoff

Keyword(s):

Recurrence Rate ◽

Tumour Size ◽

Breast Conservation ◽

Malignant Lesion ◽

Surgical Techniques ◽

Incomplete Resection ◽

Immediate Reconstruction ◽

Oncological Safety

Introduction: (Pre)malignant lesion in the breast requiring mastectomy conventionally may be treated with breast conservation by using oncoplastic breast surgical techniques, which is called therapeutic mammaplasty. However, no reliable data has been published so far as regards the oncological safety of this method. Aim: The aim of the authors was to analyse the oncological safety of therapeutic mammaplasty in a series of patients. Method: 99 patients were treated with therapeutic mammaplasty and data were collected in a breast surgical database prospectively. Results were analysed with respect to intraoperative, postoperative and long-term oncological safety. Results: Incomplete resection rate was 14.1%, which correlated with tumour size (p = 0.023), and multifocality (p = 0.012). Time between surgery (therapeutic mammaplasty) and chemotherapy was similar to time between conventional breast surgeries (wide excision, mastectomy, mastectomy with immediate reconstruction) and chemotherapy (mean 29–31 days; p<0.05). Overall recurrence rate was 6.1%, locoregional recurrence rate was 2% during 27 month (1–88) mean follow-up. Conclusions: Since literature data are based on relatively short follow-up and low patient number, it is highly important that all data on therapeutic mammaplasty is collected in a prospectively maintained breast surgical database in order to determine true recurrence after long-follow-up. Orv. Hetil., 2013, 154, 1291–1296.

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Recurrence Rate of Lumbar Disc Herniation After Standard Discectomy and Microdiscectomy: A 5-Year Study

Journal of Biomedical and Clinical Research ◽

10.2478/jbcr-2019-0020 ◽

2019 ◽

Vol 12 (2) ◽

pp. 139-146

Author(s):

Mladen E. Ovcharov ◽

Iliya V. Valkov ◽

Milan N. Mladenovski ◽

Nikolay V. Vasilev

Keyword(s):

Recurrence Rate ◽

Lumbar Disc Herniation ◽

Disc Herniation ◽

Lumbar Disc ◽

Surgical Techniques ◽

Reoperation Rate ◽

University Hospital ◽

Recurrence Rates ◽

Chi Square ◽

Common Procedure

Summary Lumbar disc herniation (LDH) is the most common pathology in young people, as well as people of active age. Despite sophisticated and new minimally invasive surgical techniques and approaches, reoperations for recurrent lumbar disc herniation (rLDH) could not be avoided. LDH recurrence rates, reported in different studies, range from 5 to 25%. The purpose of this study was to estimate the recurrence rates of LDH after standard discectomy (SD) and microdiscectomy (MD), and compare them to those reported in the literature. Retrospectively, operative reports for the period 2012-2017 were reviewed on LDH surgeries performed at the Neurosurgery Clinic of Dr Georgi Stranski University Hospital in Pleven. Five hundred eighty-nine single-level lumbar discectomies were performed by one neurosurgeon. The diagnoses of recurrent disc herniation were based on the development of new symptoms and magnetic resonance/computed tomography (MRI/CT) images showing compatible lesions in the same lumbar level as the primary lumbar discectomies. The recurrence rate was determined by using chi-square tests and directional measures. SD was the most common procedure (498 patients) followed by MD (91 patients). The cumulative reoperation rate for rLDH was 7.5%. From a total number of reoperations, 26 were males (59.1%) and 18 were females (40.9%). Reoperation rates were 7.6% and 6.6% after SD and MD respectively. The recurrence rate was not significantly higher for SD. Our recurrence rate was 7.5%, which makes it comparable with the rates of 5-25% reported in the literature.

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Atypical endometriosis: A clinicopathological study of 6 cases

10.26226/morressier.578f37f9d462b8028d88f97d ◽

2016 ◽

Author(s):

Leire Andres

Keyword(s):

Clinicopathological Study ◽

Atypical Endometriosis

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Modern molecular and biological aspects of endometriosis-associated infertility

GYNECOLOGY ◽

10.26442/20795696.2019.5.190731 ◽

2019 ◽

Vol 21 (5) ◽

pp. 12-15

Author(s):

Anastasiia S Safronova ◽

Mikhail Yu Vysokikh ◽

Vladimir D Chuprynin ◽

Natalia A Buralkina

Keyword(s):

Signaling Pathways ◽

Recurrence Rate ◽

High Recurrence Rate ◽

Modern Drug ◽

Surgical Methods ◽

Prevention And Treatment ◽

Biological Aspects ◽

Methods Of Treatment ◽

New Strategies

There is currently no consensus on the etiopathogenetic nature of endometriosis. The causes of aggressive, progressive, infiltrative growth of endometrioid tissue also remain unclear. An important problem remains the high recurrence rate of endometriosis, despite the availability of modern drug and surgical methods of treatment. The study of the central signaling pathways and the search for new key molecules is of paramount importance for a better understanding of the pathogenesis of the disease, and is also an important step in the development of new strategies for the diagnosis, prevention and treatment of endometriosis.

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