Design of a bifunctional fusion protein for ovarian cancer drug delivery: Single-chain anti-CA125 core-streptavidin fusion protein

2007 ◽  
Vol 65 (3) ◽  
pp. 398-405 ◽  
Author(s):  
Welson Wen-Shang Wang ◽  
Dipankar Das ◽  
Stephen A. McQuarrie ◽  
Mavanur R. Suresh
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Fusion Protein ◽  
Cancer Drug ◽  
Single Chain ◽  
Bifunctional Fusion Protein ◽  
Cancer Drug Delivery

scholarly journals Photo-Cured Glycol Chitosan Hydrogel for Ovarian Cancer Drug Delivery

Marine Drugs ◽  
2019 ◽  
Vol 17 (1) ◽  
pp. 41 ◽  
Author(s):  
Hoon Hyun ◽  
Min Park ◽  
Gayoung Jo ◽  
So Kim ◽  
Heung Chun ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Visible Light ◽  
Cell Viability ◽  
Water Solubility ◽  
Cancer Drug ◽  
Glycol Chitosan ◽  
Cancer Drug Delivery ◽  
Clinical Potential

In this study, we prepared an injectable drug delivery depot system based on a visible light-cured glycol chitosan (GC) hydrogel containing paclitaxel (PTX)-complexed beta-cyclodextrin (β-CD) (GC/CD/PTX) for ovarian cancer (OC) therapy using a tumor-bearing mouse model. The hydrogel depot system had a 23.8 Pa of storage modulus at 100 rad/s after visible light irradiation for 10 s. In addition, GC was swollen as a function of time. However, GC had no degradation with the time change. Eventually, the swollen GC matrix affected the releases of PTX and CD/PTX. GC/PTX and GC/CD/PTX exhibited a controlled release of PTX for 7 days. In addition, GC/CD/PTX had a rapid PTX release for 7 days due to improved water solubility of PTX through CD/PTX complex. In vitro cell viability tests showed that GC/CD/PTX had a lower cell viability percentage than the free PTX solution and GC/PTX. Additionally, GC/CD/PTX resulted in a superior antitumor effect against OC. Consequently, we suggest that the GC/CD system might have clinical potential for OC therapy by improving the water solubility of PTX, as PTX is included into the cavity of β-CD.

Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

2018 ◽  
Vol 23 (35) ◽  
Author(s):  
Sally Sabra ◽  
Mona Abdelmoneem ◽  
Mahmoud Abdelwakil ◽  
Moustafa Taha Mabrouk ◽  
Doaa Anwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
Natural Polymers ◽  
Anti Cancer ◽  
Drug Delivery Applications ◽  
Self Assembled ◽  
Cancer Drug Delivery

A Facile Magnetic Extrusion Method for Preparing Endosome‐Derived Vesicles for Cancer Drug Delivery

2021 ◽  
pp. 2008326
Author(s):  
Peng Guo ◽  
Sara Busatto ◽  
Jing Huang ◽  
Golnaz Morad ◽  
Marsha A. Moses
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
Cancer Drug Delivery ◽  
Extrusion Method

Recent Advancement and Technical Challenges in Developing Small Extracellular Vesicles for Cancer Drug Delivery

2021 ◽  
Vol 38 (2) ◽  
pp. 179-197
Author(s):  
Tianjiao Geng ◽  
Patrick Pan ◽  
Euphemia Leung ◽  
Qi Chen ◽  
Larry Chamley ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Extracellular Vesicles ◽  
Cancer Drug ◽  
Recent Advancement ◽  
Technical Challenges ◽  
Cancer Drug Delivery
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