Imine bond formation: A novel concept to incorporate peptide drugs in self-emulsifying drug delivery systems (SEDDS)

2019 ◽  
Vol 142 ◽  
pp. 92-100 ◽  
Author(s):  
Aida Dizdarević ◽  
Nuri Ari Efiana ◽  
Thi Nhu Quynh Phan ◽  
Barbara Matuszczak ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Bond Formation ◽  
Delivery Systems ◽  
Peptide Drugs ◽  
Imine Bond ◽  
Novel Concept

scholarly journals Imine bond formation as a tool for incorporation of amikacin in self-emulsifying drug delivery systems (SEDDS)

2021 ◽  
Author(s):  
Aida Dizdarević ◽  
Melani Marić ◽  
Iram Shahzadi ◽  
Nuri Ari Efiana ◽  
Barbara Matuszczak ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Bond Formation ◽  
Delivery Systems ◽  
Imine Bond

scholarly journals Novel 3D printing concept for the fabrication of time-controlled drug delivery systems

2018 ◽  
Vol 4 (1) ◽  
pp. 141-144 ◽  
Author(s):  
Jan Konasch ◽  
Alexander Riess ◽  
Michael Teske ◽  
Natalia Rekowska ◽  
Natalia Rekowska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Inkjet Printing ◽  
Drug Delivery Systems ◽  
Three Dimensional ◽  
Delivery Systems ◽  
Glycol Diacrylate ◽  
Pharmaceutical Ingredients ◽  
Poly Ethylene ◽  
Novel Concept

AbstractThree-dimensional (3D) printing has become a popular technique in many areas. One emerging field is the use of 3D printing for the development of 3D drug delivery systems (DDS) and drug-loaded medical devices. This article describes a novel concept for the fabrication of timecontrolled drug delivery systems based on stereolithography combined with inkjet printing. An inkjet printhead and an UV-LED light source have been integrated into an existing stereolithography system. Inkjet printing is used to selectively incorporate active pharmaceutical ingredients (API) during a stereolithographic 3D printing process. In an initial experimental study, poly (ethylene glycol) diacrylate (PEGDA) was used as polymer whereas 2-Hydroxy-4´-(2- hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) and Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) were used as photoinitiators. Basic structures could be manufactured successfully by the new hybrid 3D printing system.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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