Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice

2019 ◽  
Vol 855 ◽  
pp. 192-201 ◽  
Author(s):  
Sateesh Alavala ◽  
Rajendra Sangaraju ◽  
Nasiruddin Nalban ◽  
Bidya Dhar Sahu ◽  
Mahesh Kumar Jerald ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Anti Inflammatory

scholarly journals Protective Effect ofCalculus Bovis Sativuson Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Xiping Li ◽  
Yanjiao Xu ◽  
Chengliang Zhang ◽  
Li Deng ◽  
Mujun Chang ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Protective Effect ◽  
Activity Index ◽  
Disease Activity Index ◽  
Inflammatory Cells ◽  
Dextran Sulphate ◽  
Colon Tissue ◽  
Sod Activity ◽  
Dextran Sulphate Sodium ◽  
Anti Inflammatory

Calculus Bovis Sativus(CBS) is a commonly used traditional Chinese medicine, which has been reported to exhibit antispasmodic, fever-reducing, anti-inflammatory, and gallbladder-repairing effects. The present study aims to investigate the protective effect of CBS on dextran sulphate sodium- (DSS-) induced ulcerative colitis (UC) in mice. C57BL/6 male mice were exposed to 5% DSS in drinking water. CBS was given orally at 50 and 150 mg/kg once per day for 7 days. Body weight, disease activity index (DAI), colon length, colonic myeloperoxidase (MPO) activity, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) and nitric oxide (NO) levels were measured. Administration of CBS significantly reserved these changes, decreased the MPO activity and MDA and NO level, and increased the SOD activity in the colon tissue. Histological observation suggested that CBS alleviated edema, mucosal damage, and inflammatory cells infiltration induced by DSS in the colon. Moreover, CBS significantly downregulated the mRNA expression of tumor necrosis factor-α(TNF-α), interleukin- (IL-) 1βand IL-6 in the colon tissue. Our data suggested that CBS exerted protective effect on DSS-induced UC partially through the antioxidant and anti-inflammatory activities.

Dietary protocatechuic acid ameliorates dextran sulphate sodium-induced ulcerative colitis and hepatotoxicity in rats

2016 ◽  
Vol 7 (2) ◽  
pp. 913-921 ◽  
Author(s):  
Ebenezer O. Farombi ◽  
Isaac A. Adedara ◽  
Omolola V. Awoyemi ◽  
Chinonye R. Njoku ◽  
Gabriel O. Micah ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Protocatechuic Acid ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Anti Inflammatory

Protocatechuic acid (PCA) ameliorates colitis and the associated hepatotoxicity through its intrinsic anti-inflammatory and anti-oxidative properties in rats.

Anti-inflammatory effects of Lactobacillus brevis K65 on RAW 264.7 cells and in mice with dextran sulphate sodium-induced ulcerative colitis

2016 ◽  
Vol 7 (3) ◽  
pp. 387-396 ◽  
Author(s):  
Y.-W. Liu ◽  
W.-K. Ong ◽  
Y.-W. Su ◽  
C.-C. Hsu ◽  
T.-H. Cheng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Ulcerative Colitis ◽  
Lactobacillus Brevis ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Tnf Α ◽  
Anti Inflammatory

Lactic acid bacteria (LAB) with anti-inflammatory effects may be beneficial to the prevention or treatment for inflammation-related diseases, such as inflammatory bowel diseases. In an in vitro assay, heat-killed Lactobacillus brevis K65 (K65) reduced lipopolysaccharide-induced production of nitric oxide, tumour necrosis factor (TNF)-α and prostaglandin E2 in RAW 264.7 cells. In RAW 264.7 cells stably expressing an ind=ucible nitric oxide synthase (iNOS) reporter, viable K65 showed greater inhibition of iNOS production than its heat-killed form. In order to further examine the in vivo anti-inflammatory effect of K65, viable K65 was orally administered to BALB/c mice before and during the period of dextran sulphate sodium (DSS)-induced ulcerative colitis (UC). K65 improved UC symptoms, including reduced the levels of the pro-inflammatory cytokines, TNF-α, interleukin (IL)-6 and IL-1β, and lowered the activity of myeloperoxidase. Furthermore, K65 inhibited TNF-α, cyclo-oxygenase 2, forkhead box P3, and Toll-like receptor 4 mRNA expression in the colonic tissue of DSS-induced UC mice. Taken together, K65, a LAB with in vitro anti-inflammatory activity showed preventive effects on mice with DSS-induced UC by lowering the expression of inflammatory molecules.

scholarly journals Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats

2020 ◽  
Vol 64 ◽  
pp. 103602 ◽  
Author(s):  
Qian Zhou ◽  
Lei Ma ◽  
Wenyang Zhao ◽  
Wen Zhao ◽  
Xue Han ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Flaxseed Oil ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium

Induction of ulcerative colitis in mice influences the course of infection with the nematode Trichuris muris

2014 ◽  
Vol 89 (5) ◽  
pp. 593-600 ◽  
Author(s):  
M.C. Vegas-Sánchez ◽  
E. Rollán-Landeras ◽  
J.J. García-Rodríguez ◽  
F. Bolás-Fernández
Keyword(s):  
Ulcerative Colitis ◽  
Concurrent Infection ◽  
Dextran Sulphate ◽  
Oral Gavage ◽  
Acute Colitis ◽  
Trichuris Muris ◽  
Dextran Sulphate Sodium ◽  
Beneficial Effects ◽  
Chemically Induced ◽  
Inflammatory Bowel

AbstractThe aim of this study was to assess the effect of infection with the nematode whipworm Trichuris muris on the course of chemically induced acute ulcerative colitis in CBA/J mice, a strain proven to be highly resistant to infection with T. muris. Each mouse was infected with 50 embryonated eggs of T. muris by oral gavage. Acute colitis was triggered by administering 4% dextran sulphate sodium (DSS) in the drinking water for nine consecutive days at different times after infection. Concurrent infection and DSS administration exacerbate the severity of the colitis while favouring the permanence of parasites in the intestine. The induction of ulcerative colitis from days 54 to 62 post-infection (p.i.), when all worms had been expelled, ameliorated the course of the inflammatory disease. When ulcerative colitis was triggered earlier on, from days 27 to 35 p.i., the beneficial effects on inflammatory events were clearly shown with signs of mucosal epithelization and regeneration as early as day 1 after DSS administration. Previous infections by T. muris therefore accelerate recovery from subsequently induced inflammatory bowel disease and such an effect assists the nematode to persist in the intestinal niche.

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