scholarly journals Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion prepared by hot-melt extrusion

2017 ◽  
Vol 102 ◽  
pp. 71-84 ◽  
Author(s):  
Anh Q. Vo ◽  
Xin Feng ◽  
Manjeet Pimparade ◽  
Xinyou Ye ◽  
Dong Wuk Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Dispersion ◽  
Amorphous Solid ◽  
Hot Melt Extrusion ◽  
Amorphous Solid Dispersion ◽  
Melt Extrusion ◽  
Dual Mechanism ◽  
Hot Melt

Improving the Chemical Stability of Amorphous Solid Dispersion with Cocrystal Technique by Hot Melt Extrusion

2011 ◽  
Vol 29 (3) ◽  
pp. 806-817 ◽  
Author(s):  
Xu Liu ◽  
Ming Lu ◽  
Zhefei Guo ◽  
Lin Huang ◽  
Xin Feng ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Chemical Stability ◽  
Amorphous Solid ◽  
Hot Melt Extrusion ◽  
Amorphous Solid Dispersion ◽  
Melt Extrusion ◽  
Hot Melt

scholarly journals The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion platform

2020 ◽  
Vol 586 ◽  
pp. 119545 ◽  
Author(s):  
Yiwei Tian ◽  
Esther Jacobs ◽  
David S. Jones ◽  
Colin P. McCoy ◽  
Han Wu ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Drug Loading ◽  
Amorphous Solid ◽  
Hot Melt Extrusion ◽  
Amorphous Solid Dispersion ◽  
Melt Extrusion ◽  
Design And Development ◽  
High Drug ◽  
Hot Melt ◽  
High Drug Loading

scholarly journals Bioadhesive Drug Delivery System for Enhancing the Permeability of a BCS Class III Drug via Hot-Melt Extrusion Technology

2017 ◽  
Vol 18 (7) ◽  
pp. 2639-2647 ◽  
Author(s):  
Nicole S. Mendonsa ◽  
Priyanka Thipsay ◽  
Dong Wuk Kim ◽  
Scott T. Martin ◽  
Michael A. Repka
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hot Melt Extrusion ◽  
Class Iii ◽  
Melt Extrusion ◽  
Extrusion Technology ◽  
Hot Melt

Development of nobiletin–methyl hesperidin amorphous solid dispersion: Novel application of methyl hesperidin as an excipient for hot-melt extrusion

2019 ◽  
Vol 558 ◽  
pp. 215-224 ◽  
Author(s):  
Masazumi Iwashita ◽  
Kohjiro Hashizume ◽  
Masahiro Umehara ◽  
Takaaki Ishigami ◽  
Shintaro Onishi ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Hot Melt Extrusion ◽  
Amorphous Solid Dispersion ◽  
Melt Extrusion ◽  
Hot Melt

scholarly journals Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique

2018 ◽  
Vol 27 (1) ◽  
pp. 20-29A
Author(s):  
Ahmed S. Abdul Jabbar
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Hot Melt Extrusion ◽  
Dissolution Enhancement ◽  
Amorphous Solid Dispersion ◽  
Direct Compression ◽  
Compression Method ◽  
Melt Extrusion ◽  
Poorly Soluble ◽  
Hot Melt

The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique. A novel solubility improving agent plasdone  s630 was utilized. The HME raltegravir was formulated into tablet by direct compression method. The prepared tablets were assessed for all pre and post-compression parameters. The drug- excipients interaction was examined by FTIR and DSC. All formulas displayed complying with pharmacopoeial measures. The study reveals that formula prepared by utilizing drug and plasdone S630 at 1:1.5 proportion and span 20 at concentration about 30mg (trail-6) has given highest dissolution rate than contrasted with various formulas of raltegravir. Keywords: Hot melt extrusion, Raltegravir, Plasdone S630.

Fenofibrate Solid Dispersion Processed by Hot-Melt Extrusion: Elevated Bioavailability and Its Cell Transport Mechanism

2019 ◽  
Vol 16 (6) ◽  
pp. 538-547 ◽  
Author(s):  
Ting Wen ◽  
Boyi Niu ◽  
Qiaoli Wu ◽  
Yixian Zhou ◽  
Xin Pan ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Hot Melt Extrusion ◽  
In Vitro Dissolution ◽  
Amorphous Solid Dispersion ◽  
Dissolution Test ◽  
Melt Extrusion ◽  
Cell Transport ◽  
Hot Melt

Background: Fenofibrate (FNB) is an effective drug for the treatment of hypertriglyceridemia, hypercholesterolemia as well as mixed hyperlipidemia. However, due to its poor aqueous solubility, FNB has the problem of poor oral absorption followed by low bioavailability. Objective: The aim of this research was to construct FNB amorphous solid dispersion employing PVP VA64 as the carrier by hot-melt extrusion method, in order to improve the oral bioavailability. Additionally, the cell transport experiment was conducted to further investigate the mechanism of promoted osmotic absorption. Methods: The physical state of the obtained solid dispersion was characterized using SEM, DSC and XRD. Besides, in vitro Caco-2 cells were used to evaluate the cytotoxicity of the carrier and mimic gastrointestinal drug permeation. At last, in vitro dissolution test and in vivo bioavailability study were also carried out. Results: The prepared FNB solid dispersion was found to be an amorphous state after hot-melt extrusion process. In vitro cytotoxicity test on Caco-2 cells confirmed the excellent biocompatibility of the carrier PVP VA64. Besides, transwell cell transport assay and in vitro dissolution test revealed that FNB released from amorphous solid dispersion was equipped with an improved transmembrane transport and dissolution rate. Moreover, pharmacokinetic study in beagle dogs showed that comparing with commercial micronized product Lipanthyl®, the oral bioavailability of FNB solid dispersion was significantly enhanced (2.45 fold). Conclusion: In conclusion, PVP VA64 can be regarded as a promising polymer to enhance the bioavailability of poorly water-soluble drugs such as FNB processed by hot-melt extrusion. Besides, investigations on the mechanism of the enhanced penetration are expected to lay a foundation on the subsequent development of effective and practical solid dispersion.

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