Population pharmacokinetics of carvedilol enantiomers and their metabolites in healthy subjects and type-2 diabetes patients

2017 ◽  
Vol 109 ◽  
pp. S108-S115 ◽  
Author(s):  
Glauco H.B. Nardotto ◽  
Vera L. Lanchote ◽  
Eduardo B. Coelho ◽  
Oscar Della Pasqua
Keyword(s):  
Type 2 Diabetes ◽  
Population Pharmacokinetics ◽  
Healthy Subjects ◽  
Diabetes Patients

scholarly journals Variation of Carbohydrate-Active Enzyme Patterns in the Gut Microbiota of Italian Healthy Subjects and Type 2 Diabetes Patients

2017 ◽  
Vol 8 ◽  
Author(s):  
Matteo Soverini ◽  
Silvia Turroni ◽  
Elena Biagi ◽  
Sara Quercia ◽  
Patrizia Brigidi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gut Microbiota ◽  
Healthy Subjects ◽  
Active Enzyme ◽  
Carbohydrate Active Enzyme ◽  
Enzyme Patterns ◽  
Diabetes Patients

Palmitate-induced IL6 expression ameliorated by chicoric acid through AMPK and SIRT1-mediated pathway in the PBMCs of newly diagnosed type 2 diabetes patients and healthy subjects

Cytokine ◽  
2019 ◽  
Vol 116 ◽  
pp. 106-114 ◽  
Author(s):  
Zahra Arab Sadeghabadi ◽  
Nasrin Ziamajidi ◽  
Roghayeh Abbasalipourkabir ◽  
Roohollah Mohseni ◽  
Shiva Borzouei
Keyword(s):  
Type 2 Diabetes ◽  
Healthy Subjects ◽  
Newly Diagnosed ◽  
Chicoric Acid ◽  
Diabetes Patients

Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease

2004 ◽  
Vol 287 (6) ◽  
pp. E1209-E1215 ◽  
Author(s):  
Thomas Nyström ◽  
Mark K. Gutniak ◽  
Qimin Zhang ◽  
Fan Zhang ◽  
Jens Juul Holst ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Healthy Subjects ◽  
Stable Coronary Artery Disease ◽  
Artery Disease ◽  
Type 2 Diabetic ◽  
Diabetes Patients

GLP-1 stimulates insulin secretion, suppresses glucagon secretion, delays gastric emptying, and inhibits small bowel motility, all actions contributing to the anti-diabetogenic peptide effect. Endothelial dysfunction is strongly associated with insulin resistance and type 2 diabetes mellitus and may cause the angiopathy typifying this debilitating disease. Therefore, interventions affecting both endothelial dysfunction and insulin resistance may prove useful in improving survival in type 2 diabetes patients. We investigated GLP-1's effect on endothelial function and insulin sensitivity (SI) in two groups: 1) 12 type 2 diabetes patients with stable coronary artery disease and 2) 10 healthy subjects with normal endothelial function and SI. Subjects underwent infusion of recombinant GLP-1 or saline in a random crossover study. Endothelial function was measured by postischemic FMD of brachial artery, using ultrasonography. SI [in (10−4 dl·kg−1·min−1)/(μU/ml)] was measured by hyperinsulinemic isoglycemic clamp technique. In type 2 diabetic subjects, GLP-1 infusion significantly increased relative changes in brachial artery diameter from baseline FMD(%) (3.1 ± 0.6 vs. 6.6 ± 1.0%, P < 0.05), with no significant effects on SI (4.5 ± 0.8 vs. 5.2 ± 0.9, P = NS). In healthy subjects, GLP-1 infusion affected neither FMD(%) (11.9 ± 0.9 vs. 10.3 ± 1.0%, P = NS) nor SI (14.8 ± 1.8 vs. 11.6 ± 2.0, P = NS). We conclude that GLP-1 improves endothelial dysfunction but not insulin resistance in type 2 diabetic patients with coronary heart disease. This beneficial vascular effect of GLP-1 adds yet another salutary property of the peptide useful in diabetes treatment.

scholarly journals Measurement of GLP-1 in Impaired Glucose Tolerance Subjects in Comparison to Type 2 Diabetes Patients and Healthy Subjects

2013 ◽  
Vol 5 (4) ◽  
Author(s):  
Ahmed Abdullah Ebeid ◽  
Mohammad Hosam El- deen Zaghloul ◽  
Mahmoud Abdulhakam Darwish ◽  
Ossama A. Mansour
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Healthy Subjects ◽  
Diabetes Patients

Influence of CYP2C19 genotype on the pharmacokinetics of R483, a CYP2C19 substrate, in healthy subjects and type 2 diabetes patients

2010 ◽  
Vol 66 (10) ◽  
pp. 1005-1015 ◽  
Author(s):  
Katrijn Bogman ◽  
Mariabeth Silkey ◽  
Siew Pheng Chan ◽  
Brian Tomlinson ◽  
Cornelia Weber
Keyword(s):  
Type 2 Diabetes ◽  
Healthy Subjects ◽  
Cyp2c19 Genotype ◽  
Diabetes Patients

Population Pharmacokinetics of Metformin in Healthy Subjects and Patients with Type 2 Diabetes Mellitus: Simulation of Doses According to Renal Function

2013 ◽  
Vol 52 (5) ◽  
pp. 373-384 ◽  
Author(s):  
Janna K. Duong ◽  
Shaun S. Kumar ◽  
Carl M. Kirkpatrick ◽  
Louise C. Greenup ◽  
Manit Arora ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Renal Function ◽  
Population Pharmacokinetics ◽  
Healthy Subjects

scholarly journals Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0210527 ◽  
Author(s):  
Sanja Matic Petrovic ◽  
Milena Radunovic ◽  
Milena Barac ◽  
Jovana Kuzmanovic Pficer ◽  
Dusan Pavlica ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Healthy Subjects ◽  
Candida Spp ◽  
Diabetes Patients

Abstract #251: Prevalence of Vitamin D Deficiency in Type 2 Diabetes Patients in North Indian Population and its Correlation with Diabetic Complications and Comorbidities

2016 ◽  
Vol 22 ◽  
pp. 56-57
Author(s):  
Brij Makkar ◽  
Namrata Harichandan ◽  
Jugal Sharma ◽  
Rajeev Chawla ◽  
Shalini Jaggi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Diabetic Complications ◽  
Indian Population ◽  
North Indian Population ◽  
Diabetes Patients
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