Preparation and in-vitro evaluation of mesoporous biogenic silica nanoparticles obtained from rice and wheat husk as a biocompatible carrier for anti-cancer drug delivery

2021 ◽  
pp. 105866
Author(s):  
Sahar Porrang ◽  
Nader Rahemi ◽  
Soodabeh Davaran ◽  
Majid Mahdavi ◽  
Belal Hassanzadeh
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Biogenic Silica ◽  
Cancer Drug ◽  
In Vitro Evaluation ◽  
Anti Cancer ◽  
Cancer Drug Delivery ◽  
Wheat Husk

scholarly journals In vitro evaluation of the cytotoxicity of a folate-modified β-cyclodextrin as a new anti-cancer drug delivery system

2014 ◽  
Vol 81 (1-2) ◽  
pp. 85-94 ◽  
Author(s):  
Zlata Tofzikovskaya ◽  
Alan Casey ◽  
Orla Howe ◽  
Christine O’Connor ◽  
Mary McNamara
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drug ◽  
In Vitro Evaluation ◽  
Anti Cancer ◽  
Cancer Drug Delivery

99mTc-conjugated manganese-based mesoporous silica nanoparticles for SPECT, pH-responsive MRI and anti-cancer drug delivery

Nanoscale ◽  
2016 ◽  
Vol 8 (47) ◽  
pp. 19573-19580 ◽  
Author(s):  
Hongbo Gao ◽  
Xiaohang Liu ◽  
Wei Tang ◽  
Dechao Niu ◽  
Bingni Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Cancer Drug ◽  
Ph Responsive ◽  
Anti Cancer ◽  
Cancer Drug Delivery

scholarly journals In vitro evaluation of paclitaxel loaded amorphous chitin nanoparticles for colon cancer drug delivery

2013 ◽  
Vol 104 ◽  
pp. 245-253 ◽  
Author(s):  
K.T. Smitha ◽  
A. Anitha ◽  
T. Furuike ◽  
H. Tamura ◽  
Shantikumar V. Nair ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Cancer Drug ◽  
In Vitro Evaluation ◽  
Cancer Drug Delivery ◽  
Amorphous Chitin

scholarly journals Fragmented polymer nanotubes from sonication-induced scission with a thermo-responsive gating system for anti-cancer drug delivery

2014 ◽  
Vol 2 (10) ◽  
pp. 1327-1334 ◽  
Author(s):  
Guofang Chen ◽  
Ruoyao Chen ◽  
Chunxiao Zou ◽  
Danwen Yang ◽  
Zhe-Sheng Chen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Drug ◽  
Gating System ◽  
Anti Cancer ◽  
Grafting From ◽  
Cancer Drug Delivery ◽  
Polymer Nanotubes

Fragmented polymer nanotubes with a thermo-responsive gating system were prepared by a 2-fold “grafting-from” strategy and sonication-induced scission for efficient drug delivery. In vitro thermo-responsive DOX drug release and chemotoxicity were testified with such nanocarriers.

Preparation and in vitro evaluation of 5-flourouracil loaded magnetite–zeolite nanocomposite (5-FU-MZNC) for cancer drug delivery applications

2016 ◽  
Vol 77 ◽  
pp. 182-190 ◽  
Author(s):  
Tuğba Sağir ◽  
Merve Huysal ◽  
Zehra Durmus ◽  
Belma Zengin Kurt ◽  
Mehmet Senel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
In Vitro Evaluation ◽  
Drug Delivery Applications ◽  
Cancer Drug Delivery

scholarly journals 3D Printed Calcium Phosphate Cement (CPC) Scaffolds for Anti-Cancer Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1077
Author(s):  
Yan Wu ◽  
Lisa Woodbine ◽  
Antony M. Carr ◽  
Amit R. Pillai ◽  
Ali Nokhodchi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Bone Graft ◽  
Bone Cancer ◽  
Cancer Drug ◽  
Anti Cancer ◽  
3D Printed ◽  
Polymeric Solutions ◽  
Cancer Drug Delivery

One of the main applications of bone graft materials is filling the gap after the surgical removal of bone cancer or tumors. Insufficient healing commonly leads to non-union fracture which could lead to cancer resurgence or infection. Emerging 3D printing of on-demand bone graft biomaterials can deliver personalized solutions with minimized risk of relapse and recurrence of cancer after bone removal surgery. This research aims to explore 3D printed calcium phosphate cement (CPC) based scaffolds as novel anti-cancer drug delivery systems to treat bone cancer. For the study, various 3D printed CPC based scaffolds (diameter 5 mm) with interconnected pores were utilized. Various optimized polymeric solutions containing a model anticancer drug 5-fluorouracil (5-FU) was used to homogenously coat the CPC scaffolds. Both hydrophilic Soluplus (SOL) and polyethylene glycol (PEG) and a combination of both were used to develop stable coating solutions. The surface morphology of the coated scaffolds, observed via SEM, revealed deposition of the polymeric solution represented by a semi-smooth surface as opposed to the blank scaffolds that showed a smoother surface. An advanced surface analysis conducted via confocal microscopy showed a homogenous distribution of the drug throughout the coated scaffolds. Solid-state analysis studied by applying differential scanning calorimetry (DSC) and X-ray diffraction (XRD) revealed semi-crystalline nature of the drug whereas mechanical analysis conducted via texture analysis showed no evidence in the change of the mechanical properties of the scaffolds after polymeric solutions were applied. The FTIR analysis revealed no major intermolecular interactions between 5-FU and the polymers used for coatings except for F2 where a potential nominal interaction was evidenced corresponding to higher Soluplus content in the formulation. In vitro dissolution studies showed that almost 100% of the drug released within 2 h for all scaffolds. Moreover, in vitro cell culture using two different cell lines (Hek293T-human kidney immortalized cell line and HeLa-human bone osteosarcoma epithelial cell line) showed significant inhibition of cell growth as a function of decreased numbers of cells after 5 days. It can be claimed that the developed 5-FU coated 3D printed scaffolds can successfully be used as bone graft materials to potentially treat bone cancer or bone neoplasm and for personalized medical solutions in the form of scaffolds for regenerative medicine or tissue engineering applications.

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